Results 51 to 60 of about 4,404,520 (294)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Population Dynamics of the Deer Mouse (Peromyscus maniculatus) and Sin Nombre Virus, California Channel Islands

open access: yesEmerging Infectious Diseases, 1997
Hantavirus pulmonary syndrome, first documented in 1993, is caused by Sin Nombre virus (SNV), which is carried by the Peromyscus species. In 1994, high SNV antibody prevalence was identified in deer mice from two California Channel Islands.
Tim B. Graham, Bruno B. Chomel
doaj   +1 more source

Occurrence of primary aromatic amines and nicotine in sediments collected from the United States [PDF]

open access: green, 2022
Magdalena Urbaniak   +4 more
openalex   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Knowledge-Based Patient Screening for Rare and Emerging Infectious/Parasitic Diseases: A Case Study of Brucellosis and Murine Typhus

open access: yesEmerging Infectious Diseases, 1997
Many infectious and parasitic diseases, especially those newly emerging or reemerging, present a difficult diagnostic challenge because of their obscurity and low incidence.
Craig N. Carter   +7 more
doaj   +1 more source

Carbon conundrums: Do United States' current carbon market baselines represent an undesirable ecological threshold? [PDF]

open access: hybrid, 2022
Anthony W. D’Amato   +4 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Fluoroquinolone Resistance in Neisseria gonorrhoeae

open access: yesEmerging Infectious Diseases, 1997
Fluoroquinolones and broad-spectrum cephalosporins are the most effective antimicrobial agents for the treatment of gonorrhea. However, clinically significant resistance to fluoroquinolones has emerged in Neisseria gonorrhoeae.
Joan S. Knapp   +3 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Detection and Attribution of Streamflow Timing Changes to Climate Change in the Western United States [PDF]

open access: bronze, 2009
Hugo G. Hidalgo   +11 more
openalex   +1 more source

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