Results 101 to 110 of about 6,880,808 (309)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Fast Optimization Method for Reliability and Performance of Cloud Services Composition Application

Journal of Applied Mathematics, 2013
At present the cloud computing is one of the newest trends of distributed computation, which is propelling another important revolution of software industry. The cloud services composition is one of the key techniques in software development.
Zhao Wu, Naixue Xiong, Yannong Huang, Qiong Gu, Chunyang Hu, Zhongbo Wu, Bo Hang   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Functions of Generations of Educational Communities at the University

Vysshee Obrazovanie v Rossii = Higher Education in Russia
The relevance of studying the generational functions of academic and administrative staff and students is due to the need to study the potential of generational communities and its use in the development of modern universities. Understanding the problems of intergenerational relations in universities is closely related to the identification and ...
G. E. Zborovsky, P. A. Ambarova
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Triangular Neutrosophic Fuzzy Reliability Assessment of a Coal Ash Handling System in Thermal Power Plant [PDF]

Neutrosophic Sets and Systems
The fundamental role of reliability in the coal ash handling system is to improve the overall performance of the system over a specific period without any failure.
Monika Saini, Ashish Kumar, Jagriti Singh Chundawat   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Power System Reliability Assessment Considering Coal-Fired Unit Peaking Characteristics

Algorithms
The large-scale integration of renewable energy and the serious safety issues faced by coal-fired units during peak regulation pose significant challenges to the reliable operation of power systems.
Pengzhao Wang, Xueqin Tian, Kai Sun, Yi Huang, Zhidong Wang, Li Sun   +5 more
doaj   +1 more source

Universal Service League, New South Wales Branch.

, 1915
Caption title; Also available online http://nla.gov.au/nla.aus-vn1990306; FERG copy from Ferguson First World War, 1914-1919 pamphlet ...
Universal Service League (Sydney, N.S.W.)
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