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Prospects for Universal Influenza Virus Vaccine
The current vaccination strategy against influenza A and B viruses is vulnerable to the unanticipated emergence of epidemic strains that are poorly matched by the vaccine. A vaccine that is less sensitive to the antigenic evolution of the virus would be a major improvement.
Walter Gerhard +2 more
openaire +3 more sources
Vaccinations in pregnancy: An update for a changing time
Abstract Maternal immunization is one of the most effective public health interventions to reduce infectious morbidity and mortality in pregnant women, fetuses, and newborns. Despite robust evidence supporting vaccine safety and effectiveness in pregnancy, global uptake has declined following the COVID‐19 pandemic, contributing to resurgent outbreaks ...
Wendy Hodge +11 more
wiley +1 more source
Influenza vaccination in immunosuppressed and healthy individuals : DC-induced regulatory NK cell-function [PDF]
Infection with the human immunodeficiency virus (HIV) leads to immunosuppression, mainly through depletion of CD4+ T cells. Anti-retroviral therapy (ART) inhibits virus replication and thereby promotes recovery of T cell numbers and reconstitution of ...
Fritz, Stefanie
core +1 more source
Towards universal influenza vaccines? [PDF]
Vaccination is the most cost-effective way to reduce the considerable disease burden of seasonal influenza. Although seasonal influenza vaccines are effective, their performance in the elderly and immunocompromised individuals would benefit from improvement.
A. Osterhaus +2 more
openaire +3 more sources
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley +1 more source
Discordant correlation between serological assays observed when measuring heterosubtypic responses against avian influenza H5 and H7 viruses in unexposed individuals [PDF]
The human population is constantly exposed to multiple influenza A subtypes due to zoonotic spill over and rapid viral evolution driven by intrinsic error-prone replication and immunological pressure.
Ferrara, Francesca +5 more
core +1 more source
Developing broad-spectrum influenza vaccines is crucial for influenza control and potential pandemic preparedness. Here, we reported a novel vaccine design utilizing circular RNA (circRNA) as a delivery platform for multi-subtype neuraminidases (NA ...
Xinyu Yue +25 more
doaj +1 more source
Mitigating Health Disparities Through Empathetic Policymaking During Times of Crisis
ABSTRACT The COVID‐19 pandemic greatly exacerbated the existing disparities and inequities in health and healthcare among historically marginalized populations. Today, these impacts still echo. These persistent structured inequities erode the public's trust in government, lead to failure in public policies, and result in worse health consequences ...
Yali Pang +2 more
wiley +1 more source
Mitigation Strategies for Pandemic Influenza A: Balancing Conflicting Policy Objectives [PDF]
Mitigation of a severe influenza pandemic can be achieved using a range of interventions to reduce transmission. Interventions can reduce the impact of an outbreak and buy time until vaccines are developed, but they may have high social and economic ...
Heesterbeek, J.A.P. +19 more
core +2 more sources
Enterovirus infections in children
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen +11 more
wiley +1 more source

