Results 91 to 100 of about 50,247 (212)
Chasing Seasonal Influenza — The Need for a Universal Influenza Vaccine
New England Journal of Medicine, 2018 Chasing Seasonal Influenza As we prepare for a potentially severe influenza season, we must consider whether our current vaccines can be improved and whether longer-term, transformative vaccine approaches are needed to minimize influenza-related morbidity and mortality.
Catharine I, Paules +3 more
openaire +2 more sources
Is It Possible to Develop a “Universal” Influenza Virus Vaccine? [PDF]
Cold Spring Harbor Perspectives in Biology, 2017 Influenza remains a major human pathogen despite seasonal vaccination. At long last, there is energy and resources to develop influenza vaccines that provide more predictable and durable protection. Vaccines based on inducing antibodies to the conserved stem of the viral hemagglutinin (HA) have emerged as leading candidates for broadening population ...
Davide, Angeletti, Jonathan W, Yewdell
openaire +2 more sources
Wildlife Letters, EarlyView.The Amur tiger, an endangered flagship species mainly found in the Russia Far East and Northeastern China, holds immense biological importance, and has been listed under the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES).
Wei Xie +15 more
wiley +1 more source
M2e-based universal influenza vaccines: a historical overview and new approaches to development
Journal of Biomedical Science, 2019 The influenza A virus was isolated for the first time in 1931, and the first attempts to develop a vaccine against the virus began soon afterwards. In addition to causing seasonal epidemics, influenza viruses can cause pandemics at random intervals ...
Daria Mezhenskaya +2 more
doaj +1 more source
Vaccines, 2021 A universal influenza candidate vaccine that targets multiple conserved influenza virus epitopes from hemagglutinin (HA), neuraminidase (NA) and matrix (M2e) proteins was combined with the potent Army liposomal adjuvant (ALFQ) to promote induction of ...
Clara J. Sei +11 more
doaj +1 more source
Hypersensitivity to Excipients in Drugs: An EAACI Position Paper
Allergy, EarlyView.ABSTRACT Drugs contain active pharmaceutical ingredients and excipients, compounds which enhance the pharmacokinetics, stability and palatability of the pharmaceutical formulation. While most drug hypersensitivity reactions (DHR) are caused by active ingredients, excipients may also be involved.
Lene H. Garvey +10 more
wiley +1 more source
Computational Approaches and Challenges to Developing Universal Influenza Vaccines
Vaccines, 2019 The traditional design of effective vaccines for rapidly-evolving pathogens, such as influenza A virus, has failed to provide broad spectrum and long-lasting protection. With low cost whole genome sequencing technology and powerful computing capabilities,
Xueting Qiu +2 more
doaj +1 more source
Robust immunity and heterologous protection against influenza in mice elicited by a novel recombinant NP-M2e fusion protein expressed in E. coli. [PDF]
PLoS ONE, 2012 BACKGROUND: The 23-amino acid extracellular domain of matrix 2 protein (M2e) and the internal nucleoprotein (NP) of influenza are highly conserved among viruses and thus are promising candidate antigens for the development of a universal influenza ...
Wenling Wang +7 more
doaj +1 more source
Your Best Shot at Surviving the Flu Season [PDF]
, 2020 Millions of individuals become ill from the influenza virus every year. As an existing public health issue, it is important for patients to understand that the best way to combat the influenza virus is through prevention.
Liu, Isabella
core +1 more source
Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic. [PDF]
, 2018 Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world.
Alain Gagnon +11 more
core +3 more sources