Results 131 to 140 of about 50,051 (221)

Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage

Aging Cell, Volume 25, Issue 2, February 2026.
Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell, Eleanor J. Jones, Nima Gharahdaghi, Daniel J. Wilkinson, Kenneth Smith, Philip J. Atherton, Anna K. Simon, Lynne S. Cox, Ghada Alsaleh   +8 more
wiley   +1 more source

Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial. [PDF]

, 2020
BackgroundInfluenza viruses cause substantial annual morbidity and mortality globally. Current vaccines protect against influenza only when well matched to the circulating strains.
Albrecht, Randy A, Berlanda-Scorza, Francesco, Bernstein, David I, Buschle, Kristen N, Chen, Yao-Qing, Claeys, Carine, Dickey, Michelle, Dugan, Haley L, Ermler, Megan E, Feser, Jodi, Freeman, Debra, Gao, Min, García-Sastre, Adolfo, Gast, Christopher, Guptill, Jeffrey, Guthmiller, Jenna J, Hai, Rong, Henry, Carole, Innis, Bruce L, Krammer, Florian, Lan, Linda Yu-Ling, McNeal, Monica, Nachbagauer, Raffael, Naficy, Abdollah, Palese, Peter, Palm, Anna-Karin E, Shaw, Dustin G, Solórzano, Alicia, Stamper, Christopher T, Sun, Weina, Sutton, Victoria, Tepora, Micah E, Van der Wielen, Marie, Wahid, Rahnuma, Walter, Emmanuel B, Wenzel, Heather, Wilson, Patrick C, Wohlbold, Teddy John   +37 more
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Challenge Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory

Immunology, Volume 177, Issue 2, Page 254-269, February 2026.
We utilised a commercially available adjuvant formulation to study the induction, maintenance, and consequences of innate immune memory. Using functional assays on bone marrow‐derived innate cells, extensive transcriptomic analysis of haematopoietic progenitors, and challenge models of spirochetal infection, nonspecific inflammation, and model antigen ...
Samuel T. Pasco, Itziar Martín‐Ruiz, Sarai Araujo‐Aris, Diego Barriales, Janire Castelo, Leire Egia‐Mendikute, Monika Gonzalez, Jose Ezequiel Martin, Elena Molina, Maitane Mugica, Ainhoa Palacios, Iratxe Seoane, Naiara Gutiez, Estibaliz Atondo, Eneko Santos Fernández, Maddi Oyanguren, Borja Jimenez‐Lasheras, Ainize Peña‐Cearra, Ana M. Aransay, Asis Palazon, Aize Pellón, Leticia Abecia, Hector Rodriguez, Natalia Elguezabal, Juan Anguita   +24 more
wiley   +1 more source

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

New‐onset autoimmune disease following SARS‐CoV‐2 infection and mRNA vaccination in Norway: A retrospective cohort study

Journal of Internal Medicine, Volume 299, Issue 2, Page 271-282, February 2026.
Abstract Background Studies suggest an increase in autoimmune diseases following SARS‐CoV‐2 infection and/or COVID‐19‐vaccination. We aimed to describe possible associations in Norway. Methods We used information from the emergency preparedness register for COVID‐19, BeredtC19, for all residents aged 18–64 (N = 3,450,080).
Håkon Bøås, Paz Lopez‐Doriga Ruiz, Jesper Dahl, Hanne L. Gulseth, German Tapia   +4 more
wiley   +1 more source

AuNP-M2e + sCpG vaccination of juvenile mice generates lifelong protective immunity to influenza A virus infection

Immunity & Ageing, 2019
Background Influenza virus infection causes significant morbidity and mortality worldwide. Humans fail to make a universally protective memory response to influenza A because of high mutation rates in the immune-dominant influenza epitopes.
Lynn Bimler, Amber Y. Song, Duy T. Le, Ashleigh Murphy Schafer, Silke Paust   +4 more
doaj   +1 more source

Identification and In Silico Characterization of a Conserved Peptide on Influenza Hemagglutinin Protein: A New Potential Antigen for Universal Influenza Vaccine Development. [PDF]

Nanomaterials (Basel), 2023
Khalaj-Hedayati A, Moosavi S, Manta O, Helal MH, Ibrahim MM, El-Bahy ZM, Supriyanto G.   +6 more
europepmc   +1 more source

Strategies targeting hemagglutinin cocktail as a potential universal influenza vaccine. [PDF]

Front Microbiol, 2022
Liu X, Zhao T, Wang L, Li M, Sun C, Shu Y.   +5 more
europepmc   +1 more source

Global Public Goods and Global Health [PDF]

, 2012
The repair rate on electron beam welded diaphragm hasn’t been at the desired level at Siemens SIT for several years. An improvement program the past five years has reduce the repair rate from 60% to 12-15% but the goal of 5% repair rate hasn’t been met ...
Gartner, David
core   +1 more source

H1N1 Challenges Ahead [PDF]

, 2009
Examines capacities and challenges in preparing for and responding to an H1N1 flu pandemic, including vaccine issues, confusion with seasonal flu, strain on medical systems, and erosion of public health infrastructure.

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