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Closing Editorial-Special Issue on Veterinary Vaccines and Host Immune Responses. [PDF]
Vaccines (Basel)Matsuyama-Kato A, Abdul-Careem MF.
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A “universal” human influenza A vaccine
Virus Research, 2004We have previously reported on a universal human influenza A vaccine, based on the external domain of the transmembrane viral M2-protein (M2e) [Nature Medicine 5 (1999) 1119]. M2-protein is scarcely present on the virus but is abundantly expressed on virus-infected cells.
W, Fiers +4 more
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The influenza universe in an mRNA vaccine
Science, 2022An mRNA–lipid nanoparticle vaccine protects animals from 20 influenza ...
Alyson A, Kelvin, Darryl, Falzarano
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Universal Influenza Vaccination Recommendations
Journal of Public Health Management and Practice, 2006Modern vaccines-including influenza vaccine-provide a uniquely powerful and cost-effective way to prevent deadly communicable diseases from spreading. Unfortunately, since the last decade of the 20th century, influenza vaccine supply and distribution problems have steadily grown worse in the United States.
Geoffrey R, Swain, James, Ransom
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M2e-based universal influenza A vaccine
Vaccine, 2009Human influenza causes substantial morbidity and mortality. Currently, licensed influenza vaccines offer satisfactory protection if they match the infecting strain, but they come with significant drawbacks. These vaccines are derived from prototype viruses, containing the hemagglutinin of influenza viruses that are likely to cause the next epidemic ...
Walter, Fiers +7 more
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Toward a universal influenza vaccine
Science, 2021Influenza The development of a universal influenza vaccine is of paramount importance because seasonal vaccines vary in terms of protection. Darricarrere et al. have now moved a universal influenza vaccine one step closer to the clinic. The authors vaccinated nonhuman primates with headless hemagglutinin-stabilized stem antigens presented on ferritin ...
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Universal Influenza Vaccination and Live Attenuated Influenza Vaccination of Children
Pediatric Infectious Disease Journal, 2008Influenza is an uncontrolled epidemic disease that is vaccine preventable. Each winter the peak of medically attended acute respiratory illness coincides with the peak of influenza virus activity. The anatomy of an urban influenza epidemic is presented highlighting the role of children in the spread of influenza.
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Universal influenza vaccination: Future prospects
Vacunas (English Edition), 2019Abstract The current influenza vaccines only contain the complete haemagglutinin (HA) of influenza as only immunogen determining a little lasting immunity. This phenomenon is due to the fact that they are based almost exclusively on inducing an immune response against the globular domain (head) of the HA (subunit HA1), since it has been observed that
J. Reina, N. Reina
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Tracking progress in universal influenza vaccine development
Current Opinion in Virology, 2020Conventional influenza vaccines are designed to stimulate neutralizing antibodies against immunodominant but highly variable hemagglutinin antigens. Inherent limitations include suboptimal protection against rapidly changing seasonal influenza viruses and a lack of protection against antigenically novel pandemic influenza.
Julie Ostrowsky +9 more
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Research and development of universal influenza vaccines
Microbes and Infection, 2010The continuous threat of influenza pandemics determines the urgency and necessity to develop safe and effective vaccines against divergent influenza viruses. This review describes the advancements in the research and development of universal influenza vaccines based on the relatively conserved sequences of M2e, HA, and other proteins of influenza ...
Lanying, Du, Yusen, Zhou, Shibo, Jiang
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