A universal opportunity model for human mobility [PDF]
, 2020 Erjian Liu, Xiao-Yong Yan
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Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
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Universal extracellular vesicles and PD-L1+ extracellular vesicles detected by single molecule array technology as circulating biomarkers for diffuse large B cell lymphoma [PDF]
, 2021 J Y Li +10 more
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Universality after Universalism
, 2023 The idea of universalism inherited from the French Revolution has been strongly discredited by its colonial history; today, it is also the target of nationalist attacks. What remains of it? Now available in English, Markus Messling's critically acclaimed study shows how contemporary Francophone literatures seek, after European universalism, approaches ...
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ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
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SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
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O currículo entre o relativismo e o universalismo Curriculum: between relativism and universalism
Educação & Sociedade, 2000 O texto examina a questão do relativismo e do universalismo no currículo. Segundo o autor, os relativistas defendem o questionamento da validade do que se ensina.
Jean-Claude Forquin
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BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
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Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
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NILAI DAN PENGARUHNYA TERHADAP PERENCANAAN KEUANGAN KELUARGA DALAM PEMBELIAN ASURANSI JIWA
Jurnal Ilmu Keluarga dan Konsumen, 2013 Life insurance is one of many ways to anticipate risks in the future. The aim of this research was to analyze value due to the priorities scale of its dimension, to analyze information access, and to analyze their influences towards financial planning in
Denissa Chika Finira, Lilik Noor Yuliati
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