Results 31 to 40 of about 691,819 (289)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Il Dams come nuovo indirizzo universitario tra sapere tecnico e sapere umanistico. Intervista a Claudio Bisoni e Paolo Noto

E-Review. Rivista degli Istituti Storici dell'Emilia-Romagna in Rete, 2018
Claudio Bisoni and Paolo Noto focus on the history of Dams (Discipline delle arti della musica e dello spettacolo), a university course created in 1970 as the outcome of the union of traditional and innovative knowledge.
Alessandro Breccia, Simona Salustri
doaj   +1 more source

University teaching in prison in the university penitentiary system of Sassari: practices, research and developments during the pandemic

Formare, 2021
This paper derives from the activities of the University Penitentiary Center of the University of Sassari and aims to explore the impact of the Covid 19 pandemic on university teaching in prison.
Luisa Pandolfi, Emmanuele Farris
doaj   +1 more source

Measurement of resonant and CP components in B0s→J/ψπ+π− decays [PDF]

, 2014
Structure of the decay B̄s0→J/ψπ+π- is studied using data corresponding to 3fb-1 of integrated luminosity from pp collisions produced by the LHC and collected by the LHCb detector.
Back, J. J., Blake, Thomas, Craik, Daniel, Dossett, D., Gershon, T. J., HASH(0x5618724dac40), Kreps, Michal, Latham, Thomas, Pilar, T., Poluektov, Anton, Reid, Matthew M., Silva Coutinho, R., Wallace, Charlotte, Whitehead, M. (Mark), Williams, M. P.   +14 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

PAOLO MANTEGAZZA: RETTORE DELL’UNIVERSITÀ DEGLI STUDI DI MILANO

Istituto Lombardo - Accademia di Scienze e Lettere • Incontri di Studio, 2018
Paolo Mantegazza has been Rector of the University of Milan for four consecutive mandates, from 1984 to 2001, after having been for 10 years Dean of the Medicine and Surgery Faculty (from 1974 to 1984). His rectorship period has been a time of great change in the society but also in university, as a result of the Universityre form law, Decree 382 ...
openaire   +2 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Politiche territoriali e sviluppo dei poli universitari nella regione Emilia-Romagna (1945-1968)

E-Review. Rivista degli Istituti Storici dell'Emilia-Romagna in Rete, 2018
Le università sono soggetti che per loro natura dispiegano verso il loro contesto un variegato insieme di dinamiche di scambio, tali da influire in modo evidente sulle scelte di pianificazione del territorio. Le vicende che hanno visto lo sviluppo
Luca Gullì
doaj   +1 more source

Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) risk differs by sex and age, implicating sex hormones as potential modifiers. This study examined plasma levels of biologically active sex hormones and their association with ALS odds and survival in cases (females n = 131, males n = 189) and controls (females n = 138, males n = 150) from the University of ...
Stephen A. Goutman, David G. Stouffer, Dae‐Gyu Jang, Jihyun Park, Benjamin J. Murdock, Richard J. Auchus   +5 more
wiley   +1 more source

Un processo di epurazione all’Università di Bologna: il caso di Luigi Simeoni (1945-1947)

Studi Veronesi, 2023
La vicenda dell’epurazione dello storico veronese Luigi Simeoni (1875-1952), docente all’Università di Bologna tra il 1927 e il 1950, è nota nelle sue linee generali, con un primo allontanamento dall’insegnamento universitario (giugno 1945) e il ...
Enrico Zanetti
doaj