Results 161 to 170 of about 10,508,058 (244)

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Developing a Shared Understanding of Humanism in Health Care Through Critical Review and Empirical Exploration: Protocol for a Modified e-Delphi Study. [PDF]

JMIR Res Protoc
Guay D, Turcotte A, April MJ, Foley V, Beauchamp J, Marquis N, Héon-Lepage M.   +6 more
europepmc   +1 more source

D’une université campus à une université multi-modale

Distances et Médiations des Savoirs, 2016
Didier Paquelin
doaj   +1 more source

Optically Tunable Threshold Switching and Thermally Activated Transport in Planar Ag/MAPbI3 Thin Single‐Crystal Devices

Advanced Science, EarlyView.
Planar Ag/MAPbI3 thin single‐crystal halide perovskite devices show ultralow dark current and optically tunable threshold switching. Illumination enhances the polarity‐dependent hysteresis and shifts the switching voltage, whereas temperature‐dependent measurements reveal thermally activated, contact‐limited transport, underscoring the central role of ...
Ofelia Durante, Valeria Demontis, Sebastiano De Stefano, Selene Matta, Adolfo Mazzotti, Daniela Marongiu, Emanuele Meloni, Elisa Pili, Fang Liu, Nicola Sestu, Angelica Simbula, Mauro Carta, Michele Saba, Andrea Mura, Massimiliano Di Ventra, Giovanni Bongiovanni, Antonio Di Bartolomeo   +16 more
wiley   +1 more source

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

Advanced Science, EarlyView.
Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi, Nicolas Carvalho, Jacinthe Frangieh, Corentin Léger, Dorothée Raoux‐Barbot, J. Iñaki Guijarro, Daniel Ladant, Sophie Cribier, Nicolas Rodriguez, Alexandre Chenal   +9 more
wiley   +1 more source

Beyond pharmaceutical bandaids: universal access to antiretroviral therapy in Canada. [PDF]

CMAJ
Brisson J, Sheehan N, Lemire B, Monteith K, David PM.   +4 more
europepmc   +1 more source

Mesoporous PU/PEDOT:PSS Electrodes Reveal Population‐Level Stochastic Bioelectrical Dynamics in Marine Diatoms

Advanced Science, EarlyView.
Mesoporous mixed ionic‐electronic PU/PEDOT: PSS electrodes enable label‐free detection of stochastic extracellular bioelectrical dynamics in living Phaeodactylum tricornutum. Living diatoms actively modulate interfacial ionic dynamics, establishing stochastic electrochemical noise as a sensitive probe of microbial bioelectrochemical activity and a new ...
David M. S. Silva, Felipe L. Bacellar, Raquel Amaral, Louis‐Josselin Lavier‐Aydat, Luísa Cortes, Kamal Asadi, Leïla Tirichine, Paulo R. F. Rocha   +7 more
wiley   +1 more source

[10^th International francophone forum on health sciences education]. [PDF]

Can Med Educ J
europepmc   +1 more source

Reply to: Data from the ROPAD study corroborate an association between ITSN1 loss-of-function variants and Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Cogan G, Tesson C, Welment L, Clot F, LeGuern E, Lanore A, Dürr A, Cormier-Dequaire F, Debilly B, Planes M, Mangone G, Lesage S, Brice A.   +12 more
europepmc   +1 more source

Low Latency Global Carbon Budget Reveals Late 2024 Carbon Losses and Contrasting Early 2025 Land Sink Recovery Signals

Advanced Science, EarlyView.
Low latency carbon budget estimates for July 2024–June 2025 combine atmospheric CO2 growth rates, fossil emissions, ocean uptake, DGVM land fluxes, and OCO‐2 inversions. The budget shows that late‐2024 land carbon losses dominate the annual anomaly, while early‐2025 recovery differs between bottom‐up models and top‐down inversions, especially in ...
Piyu Ke, Philippe Ciais, Yitong Yao, Stephen Sitch, Wei Li, Xiaomeng Du, Xiaofan Gui, Ben Poulter, Thomas Colligan, Auke M. van der Woude, Joram Hooghiem, Wouter Peters, Zhu Liu, Zhu Deng, Zhe Jin, Xiangjun Tian, Yilong Wang, Junjie Liu, Sudhanshu Pandey, Chris O'Dell, Jiang Bian, John Miller, Xin Lan, Jefferson Goncalves De Souza, Michael O'Sullivan, Pierre Friedlingstein, Julien Alléon, Yi Xi, Daniel S. Goll, Lei Zhu, Guido R. van der Werf, Shilong Piao, Frédéric Chevallier   +32 more
wiley   +1 more source