Results 1 to 10 of about 1,161,376 (184)

D- and Unnatural Amino Acid Substituted Antimicrobial Peptides With Improved Proteolytic Resistance and Their Proteolytic Degradation Characteristics. [PDF]

Front Microbiol, 2020
The transition of antimicrobial peptides (AMPs) from the laboratory to market has been severely hindered by their instability toward proteases in biological systems.
Lu J, Xu H, Xia J, Ma J, Xu J, Li Y, Feng J.   +6 more
europepmc   +2 more sources

Trifluoroselenomethionine: A New Unnatural Amino Acid [PDF]

ChemBioChem, 2016
AbstractTrifluoroselenomethionine (TFSeM), a new unnatural amino acid, was synthesized in seven steps from N‐(tert‐butoxycarbonyl)‐l‐aspartic acid tert‐butyl ester. TFSeM shows enhanced methioninase‐induced cytotoxicity, relative to selenomethionine (SeM), toward HCT‐116 cells derived from human colon cancer.
Eric Block, Squire J. Booker, Sonia Flores‐Penalba, Graham N. George, Sivaji Gundala, Bradley J. Landgraf, Jun Liu, Stephene N. Lodge, M. Jake Pushie, Sharon Rozovsky, Abith Vattekkatte, Rama Yaghi, Huawei Zeng   +12 more
openaire   +4 more sources

Fermentative production of the unnatural amino acid L-2-aminobutyric acid based on metabolic engineering. [PDF]

Microb Cell Fact, 2019
Backgroundl-2-aminobutyric acid (l-ABA) is an unnatural amino acid that is a key intermediate for the synthesis of several important pharmaceuticals.
Xu JM, Li JQ, Zhang B, Liu ZQ, Zheng YG.
europepmc   +2 more sources

Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis. [PDF]

Proc Natl Acad Sci U S A, 2019
Significance Glutamate receptors are membrane proteins that incorporate an ion channel domain. Binding of the neurotransmitter glutamate opens the ion channel, a key event in neurotransmission, but also triggers other dynamic changes in protein structure.
Poulsen MH, Poshtiban A, Klippenstein V, Ghisi V, Plested AJR.   +4 more
europepmc   +2 more sources

Unnatural amino acid analogues of membrane-active helical peptides with anti-mycobacterial activity and improved stability

Journal of Antimicrobial Chemotherapy, 2016
Objectives The emergence of MDR-TB, coupled with shrinking antibiotic pipelines, has increased demands for new antimicrobials with novel mechanisms of action. Antimicrobial peptides have increasingly been explored as promising alternatives to antibiotics,
Ee, PLR, Hamilton, MS, Khara, JS, Krishnan, N, Langford, PR, Newton, SM, Priestman, M, Robertson, BD, Uhia, I, Wang, Y, Yang, YY   +10 more
core   +2 more sources

Unnatural Amino Acid Incorporation into Virus-Like Particles [PDF]

Bioconjugate Chemistry, 2008
Virus-like particles composed of hepatitis B virus (HBV) or bacteriophage Qβ capsid proteins have been labeled with azide- or alkyne-containing unnatural amino acids by expression in a methionine auxotrophic strain of E. coli.
Brown, Steven, Carragher, Bridget, Finn, M. G., Lander, Gabriel, Link, A. James, Ngo, John T., Potter, Clinton S., Prasuhn, Duane E., Quispe, Joel, Strable, Erica, Tirrell, David A., Udit, Andrew K.   +11 more
core   +6 more sources

Investigation of Trimethyllysine Binding by the HP1 Chromodomain via Unnatural Amino Acid Mutagenesis. [PDF]

J Am Chem Soc, 2017
Baril SA, Koenig AL, Krone MW, Albanese KI, He CQ, Lee GY, Houk KN, Waters ML, Brustad EM.   +8 more
europepmc   +2 more sources

Reprogramming natural proteins using unnatural amino acids

RSC Advances, 2021
Incorporation of unnatural amino acids into protein offers wide array of applications in fundamental and applied science.
Anup Adhikari, Bibek Raj Bhattarai, Ashika Aryal, Niru Thapa, Puja KC, Ashma Adhikari, Sushila Maharjan, Prem B. Chanda, Bishnu P. Regmi, Niranjan Parajuli   +9 more
openaire   +3 more sources

Metabolism of amino acid amides in Pseudomonas putida ATCC 12633 [PDF]

, 1993
The metabolism of the natural amino acid L-valine, the unnatural amino acids D-valine, and D-, L-phenylglycine (D-, L-PG), and the unnatural amino acid amides D-, L-phenylglycine amide (D, L-PG-NH2) and L-valine amide (L-Val-NH2) was studied in ...
Croes, L.M.,, Dijkhuizen, L.,, Hermes, H.F.M.,, Peeters, W.P.H.,, Peters, P.J.H.,   +4 more
core   +1 more source

An engineered Tetrahymena tRNA(Gln) for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression [PDF]

, 1996
A new tRNA, THG73, has been designed and evaluated as a vehicle for incorporating unnatural amino acids site-specifically into proteins expressed in vivo using the stop codon suppression technique.
Abelson, John N., Dougherty, Dennis A., Du, Fangyong, Kearney, Patrick C., Lester, Henry A., Nowak, Mark W., Saks, Margaret E., Sampson, Jeffrey R.   +7 more
core   +1 more source