Biochemistry and Biophysics Reports, 2018 Many biophysical techniques that are available to study the structure, function and dynamics of cellular constituents require modification of the target molecules.
Leonhard Jakob +2 more
semanticscholar +3 more sources
Frontiers in Chemistry, 2014 Unnatural amino acid (UAA) incorporation by amber codon suppression offers scientists a powerful tool to modify the properties of proteins at will. UAA incorporation has been used for a plethora of fundamental research applications and, more recently ...
Kim Wals, H. Ovaa
semanticscholar +3 more sources
Unnatural Amino Acid: 4-Aminopyrazolonyl Amino Acid Comprising Tri-Peptides Forms Organogel With Co-Solvent (EtOAc:Hexane). [PDF]
Front Chem, 2022 Ampyrone is an amino-functionalized heterocyclic pyrazolone derivative that possesses therapeutic values such as analgesic, anti-inflammatory, and antipyretics.
Bollu A +4 more
europepmc +2 more sources
5-Amino-3-methyl-Isoxazole-4-carboxylic Acid as a Novel Unnatural Amino Acid in the Solid Phase Synthesis of α/β-Mixed Peptides. [PDF]
Molecules, 2022 The hybrid peptides consisting of α and β-amino acids show great promise as peptidomimetics that can be used as therapeutic agents. Therefore, the development of new unnatural amino acids and the methods of their incorporation into the peptide chain is ...
Bąchor U +3 more
europepmc +2 more sources
An Unnatural Amino Acid-Regulated Growth Controller Based on Informational Disturbance. [PDF]
Life (Basel), 2021 We designed a novel growth controller regulated by feeding of an unnatural amino acid, Nε-benzyloxycarbonyl-l-lysine (ZK), using a specific incorporation system at a sense codon. This system is constructed by a pair of modified pyrrolisyl-tRNA synthetase
Kato Y.
europepmc +2 more sources
A linear DNA template-based framework for site-specific unnatural amino acid incorporation. [PDF]
Synth Syst Biotechnol, 2021 Site-specific incorporation of unnatural amino acids (UNAAs) into proteins using an orthogonal translation system (OTS) has expanded the scope of protein-coding chemistry. The key factor affecting UNAA embedding efficiency is the orthogonality of the OTS.
Chen X, Liu Y, Hou J, Lu Y.
europepmc +2 more sources
Unnatural amino acid substitutions to improve in vivo stability and tumor uptake of 68Ga-labeled GRPR-targeted TacBOMB2 derivatives for cancer imaging with positron emission tomography. [PDF]
EJNMMI Radiopharm ChemBackground Overexpressed in various solid tumors, gastrin-releasing peptide receptor (GRPR) is a promising cancer imaging marker and therapeutic target. Although antagonists are preferable for the development of GRPR-targeted radiopharmaceuticals due to ...
Wang L +9 more
europepmc +2 more sources
An unnatural amino acid dependent, conditional Pseudomonas vaccine prevents bacterial infection. [PDF]
Nat CommunLive vaccines are ideal for inducing immunity but suffer from the need to attenuate their pathogenicity or replication to preclude the possibility of escape.
Pigula M +6 more
europepmc +2 more sources
Development and Testing of Force Field Parameters for Phenylalanine and Tyrosine Derivatives
Frontiers in Molecular Biosciences, 2020 Theoretical analyses are valuable for the exploration of the effects of unnatural amino acids on enzyme functions; however, many necessary parameters for unnatural amino acids remain lacking.
Xiaowen Wang, Xiaowen Wang, Wenjin Li
doaj +1 more source
Enzymatic Screening of β-Amyloid Precursor Protein-Based Substrates
Compounds, 2023 We performed an enzymatic screening of synthetic peptides based on β-amyloid precursor protein substrates. The template peptide sequence was a decapeptide derived from our previous screening study, which determined several effective unnatural amino acids.
Reo Yamada +5 more
doaj +1 more source