Results 41 to 50 of about 1,288,650 (300)

Exploiting Photoredox Catalysis for Rapid Access to Unnatural α-Amino Acids through α-Amino C–H Bond Activation [PDF]

Unnatural amino acids (UAAs) have shown great potential to enhance the pharmacological properties of peptides and represent a key motif in a wide range of biologically relevant natural products.
Till , Kalkuhl, Marco , Bormetti, Lucas , Kusch, Gregory R. , Alvey, Ludwig , Wåhlin, Markus D., Kärkäs, Elena V. , Stepanova, Andrey , Shatskiy, Moritz , Schepp, Chang Ho , Lee   +9 more
core   +1 more source

Development of natural and unnatural amino acid delivery systems against hookworm infection

Precision Nanomedicine, 2020
Peptide-based vaccines consist of short antigen fragments derived from a specific pathogen. Alone, these peptide fragments are poorly or non-immunogenic; however, when incorporated into a proper delivery system, they can trigger strong immune responses.
Stacey Bartlett, Mariusz Skwarczynski, Xin Xie, Istvan Toth, Alex Loukas, Ramon M Eichenberger   +5 more
doaj   +1 more source

Strategies to transform remote C(sp3)-H bonds of amino acid derivatives

Tetrahedron Chem, 2022
Amino acids and peptides play an important role in nature as well as in the pharmaceutical industry. Therefore, transformation of amino acids and peptides into their unnatural derivatives via step and atom economical ways is highly demanding. Although, a
Supreeta Sen, Jayabrata Das, Debabrata Maiti   +2 more
doaj   +1 more source

Employing Unnatural Amino Acids in the Preparation of Bioconjugates [PDF]

Synlett, 2016
The exploitation of unnatural amino acid (UAA) technologies represents an excellent mechanism for the generation of site-specific bioconjugates. Consequently, significant effort has been invested in the advancement of the technology via the integration of novel bioconjugation reactions and the expansion of the set of UAAs that can be employed.
Douglas Young, Johnathan Maza, Taylor Jacobs, Diya Uthappa   +3 more
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Genetic Code Expansion of Vibrio natriegens

Frontiers in Bioengineering and Biotechnology, 2021
Escherichia coli has been considered as the most used model bacteria in the majority of studies for several decades. However, a new, faster chassis for synthetic biology is emerging in the form of the fast-growing gram-negative bacterium Vibrio ...
Eden Ozer, Lital Alfonta
doaj   +1 more source

Chemo-enzymatic synthesis of unnatural amino acids

, 2009
A general chemo-enzymatic process has been developed to prepare enantiomerically pure L- and D-amino acids in high yield by deracemisation of racemic starting materials. The method has been developed from initial academic studies to be a robust, scalable
Speight, Robert, Taylor, Paul, Arnold, S. Alison, Carr, Reuben, Fotheringham, Ian, Archer, Ian   +5 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates

Nature Communications, 2023
Site-specific protein multi-conjugates are important for both scientific and translational research. Here, the authors genetically encode unnatural amino acids which contain both tetrazine and azide, and use the doubly bio-orthogonal handles to generate ...
Yong Wang, Jingming Zhang, Boyang Han, Linzhi Tan, Wenkang Cai, Yuxuan Li, Yeyu Su, Yutong Yu, Xin Wang, Xiaojiang Duan, Haoyu Wang, Xiaomeng Shi, Jing Wang, Xing Yang, Tao Liu   +14 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source