Results 111 to 120 of about 56,044 (294)

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Metabolic effects of an aspartate aminotransferase-inhibitor on two T-cell lines.

PLoS ONE, 2018
An emerging method to help elucidate the mode of action of experimental drugs is to use untargeted metabolomics of cell-systems. The interpretations of such screens are however complex and more examples with inhibitors of known targets are needed.
Henrik Antti, Magnus Sellstedt
doaj   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

Filtering procedures for untargeted LC-MS metabolomics data

BMC Bioinformatics, 2019
Background Untargeted metabolomics datasets contain large proportions of uninformative features that can impede subsequent statistical analysis such as biomarker discovery and metabolic pathway analysis.
Courtney Schiffman, Lauren Petrick, Kelsi Perttula, Yukiko Yano, Henrik Carlsson, Todd Whitehead, Catherine Metayer, Josie Hayes, Stephen Rappaport, Sandrine Dudoit   +9 more
doaj   +1 more source

MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis. [PDF]

, 2015
Data-independent acquisition (DIA) in liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS) provides comprehensive untargeted acquisition of molecular data.
Arita, Masanori, Cajka, Tomas, Fiehn, Oliver, Higgins, Brendan, Ikeda, Kazutaka, Kanazawa, Mitsuhiro, Kind, Tobias, Ma, Yan, Tsugawa, Hiroshi, VanderGheynst, Jean   +9 more
core  

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

mzLearn as a data-driven LC/MS signal detection algorithm that enables pre-trained generative models for untargeted metabolomics

Communications Chemistry
Metabolite alterations are linked to diseases, yet large-scale untargeted metabolomics remains constrained by challenges in signal detection and integration of diverse datasets for developing pre-trained generative models.
Leila Pirhaji, Jonah Eaton, Adarsh K. Jeewajee, Min Zhang, Matthew Morris, Maria Karasarides   +5 more
doaj   +1 more source

Effective data visualization strategies in untargeted metabolomics

Natural Product Reports
Untargeted metabolomics faces researchers with complex processing, analysis, and interpretation tasks. Here, we review computational tools from the perspective of information visualization and underpin its critical role and importance to the field.
Kevin Mildau, Henry Ehlers, Mara Meisenburg, Elena Del Pup, Robert A. Koetsier, Laura Rosina Torres Ortega, Niek F. de Jonge, Kumar Saurabh Singh, Dora Ferreira, Kgalaletso Othibeng, Fidele Tugizimana, Florian Huber, Justin J. J. van der Hooft   +12 more
openaire   +3 more sources

Untargeted Metabolomics Analysis Based on LC-QTOF-MS to Investigate the Phenolic Composition of Red and White Wines Elaborated from Sonicated Grapes

Foods
Ultrasounds are considered an emerging technology in the wine industry. Concretely, in 2019, the International Organization of Vine and Wine (OIV) officially approved their use for the treatment of crushed grapes to increase the level of phenolic ...
Alejandro Martínez-Moreno, Paula Pérez-Porras, Ana Belén Bautista-Ortín, Encarna Gómez-Plaza, Fernando Vallejo   +4 more
doaj   +1 more source

Normalizing Untargeted Periconceptional Urinary Metabolomics Data: A Comparison of Approaches

Metabolites, 2019
Metabolomics studies of the early-life exposome often use maternal urine specimens to investigate critical developmental windows, including the periconceptional period and early pregnancy.
Ana K. Rosen Vollmar, Nicholas J. W. Rattray, Yuping Cai, Álvaro J. Santos-Neto, Nicole C. Deziel, Anne Marie Z. Jukic, Caroline H. Johnson   +6 more
doaj   +1 more source