Results 91 to 100 of about 124,046 (257)
Advanced Science, EarlyView.The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li +9 more
wiley +1 more source
Effective data visualization strategies in untargeted metabolomics
LC-MS/MS-based untargeted metabolomics is a rapidly developing research field spawning increasing numbers of computational metabolomics tools assisting researchers with their complex data processing, analysis, and interpretation tasks.
Koetsier, Robert A. +12 more
core +1 more source
Untargeted metabolomics analysis based on HFCS-induced colitis
, 2023 Untargeted metabolomics ...
Mingxia Zhou (17040888)
core +1 more source
Advanced Science, EarlyView.Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao +9 more
wiley +1 more source
Torin1, a selective kinase inhibitor targeting the mammalian target of rapamycin (mTOR), remains widely used in autophagy research due to its potent autophagy-inducing abilities, regardless of its unspecific properties.
Katyeny Manuela da Silva +8 more
core +1 more source
Handling Missing Values in Untargeted Metabolomics Data
, 2019 Currently, the majority of studies using metabolomics data assume that missing values are due to low concentration and impute the missing values to a single value, e.g. half detection threshold, which was shown very high bias4.
Diana van Heemst (28182) +10 more
core +1 more source
Multiplatform untargeted metabolomics [PDF]
, 2023 Metabolomics samples like human urine or serum contain upwards of a few thousand metabolites, but individual analytical techniques can only characterize a few hundred metabolites at best.
Powers, Robert, Jeppesen, Micah J.
core
The evolving landscape of untargeted metabolomics
, 2021 Aims: Untargeted Metabolomics is a "hypothesis-generating discovery strategy" that compares groups of samples (e.g., cases vs controls); identifies the metabolome and establishes (early signs of) perturbations.
Castaldo G. +4 more
core +1 more source
Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
Background/Objectives: Millions of new diagnoses of breast cancer are made each year, with many cases having poor prognoses and limited treatment options, particularly for some subtypes such as triple-negative breast cancer.
Isabella G. Falcone, Blake R. Rushing
core +1 more source