Results 221 to 230 of about 56,044 (294)

Untargeted Metabolomics for Profiling of Cascara, Senna, Rhubarb, and Frangula Metabolites. [PDF]

Metabolites
Nezi P, Prete AL, Costanti F, Cicaloni V, Cicogni M, Tinti L, Salvini L, Bianchini M.   +7 more
europepmc   +1 more source

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1494-1502, June 2026.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

Exploratory analysis of epilepsy biomarkers using untargeted metabolomics across multiple cohorts. [PDF]

Front Neurol
Oja KT, Ilisson M, Reinson K, Muru K, Reimand T, Peterson H, Fishman D, Haller T, Kronberg J, Estonian Biobank Research Team, Wojcik MH, Kennedy AD, Sommerville L, Michelotti G, O'Donnell-Luria A, Õiglane-Shlik E, Pajusalu S, Õunap K.   +17 more
europepmc   +1 more source

Modulation of Ferroptosis Biomarkers by Thinned Apple Polyphenols Extract in Acute and Chronic Lung Injuries

eFood, Volume 7, Issue 3, June 2026.
Thinned apple polyphenols (TAP) extract reduced ferroptosis in acute and chronic lung injuries. TAP activated Nrf2 and modulated key biomarkers (MDA, NOX4, GPX4, FTH1), leading to decreased inflammation and fibrosis. These findings suggest TAP as a potential therapeutic approach for lung injury through ferroptosis regulation. ABSTRACT Acute and chronic
Rosalba Siracusa, Alessia Arangia, Marika Cordaro, Roberta Fusco, Salvatore Cuzzocrea, Giancarlo Aldini, Daniela Impellizzeri, Rosanna Di Paola, Ramona D'Amico   +8 more
wiley   +1 more source

Untargeted Metabolomics Reveals Distinct Soil Metabolic Profiles Across Land Management Practices. [PDF]

Metabolites
Vickery ZA, Castro HF, Dearth SP, Tague ED, Classen AT, Moore JA, Strickland MS, Campagna SR.   +7 more
europepmc   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1987-2002, June 2026.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

A Taguchi Design of Experiments Approach for Untargeted Metabolomics Sample Preparation Optimization. [PDF]

J Biomol Tech
Garcia BM, Gouveia GJ, Shaver AO, Borges RM, Amster IJ, Edison AS, Iii FEL.   +6 more
europepmc   +1 more source

Gas Chromatography‐Based Methods for Profiling Volatile Off‐Aroma Compounds in Grain Legumes: A Review

Legume Science, Volume 8, Issue 2, June 2026.
ABSTRACT Instrumental characterisation of the volatile organic compounds (VOCs), responsible for off‐aroma, is mainly centred on gas chromatography‐based techniques. Despite previous reviews that have addressed the chemical compounds and biosynthetic pathways of off‐aroma generation, to date, there is a lack of a comprehensive review that critically ...
Piyumi Chathurangi Wanniarachchi, K. G. Upul Kumarasinghe, Mauro Mocerino, Ranil Coorey   +3 more
wiley   +1 more source

Untargeted metabolomics analysis of <i>Physalis pubescens L.</i> with respect to different varieties. [PDF]

Front Nutr
Yan S, Li J, Chen K, Shan S, Zhang S, Gao Y, Liu B.   +6 more
europepmc   +1 more source