Results 111 to 120 of about 25,321,967 (307)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Contractual Landmines

This page contains the code and data necessary to replicate the results of "Contractual Landmines" by Robert E. Scott, Stephen J. Choi, & Mitu Gulati, published in the Yale Journal on Regulation (2024)
Journal on Regulation, Yale
core   +1 more source

Up-regulation of PI3K expression and ERK phosphorylation in Nf1^+/- mice.

, 2018
Western blot analysis of protein expression showing up-regulation in PI3K and phosphorylated ERK (pERK) with similar ERK expression in Nf1+/- testes compared to Nf1+/+ testes.
Cornelis van Breemen (280460), Kimberly A. Jett (6107750), Jan M. Friedman (351844), Harleen Chohan (6107744), Darian Arman (6107747), Catherine D. Van Raamsdonk (2475), Mitra Esfandiarei (280455)   +6 more
core   +1 more source

Mindfulness and Emotion Regulation: Insights from Neurobiological, Psychological, and Clinical Studies

Frontiers in Psychology, 2017
There is increasing interest in the beneficial clinical effects of mindfulness-based interventions (MBIs). Research has demonstrated their efficacy in a wide range of psychological conditions characterized by emotion dysregulation.
S. Guendelman, Sebastián Medeiros, H. Rampes   +2 more
semanticscholar   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Editorial: Altered Expression of Proteins in Cancer: Function and Potential Therapeutic Targets

Frontiers in Oncology, 2022
João Pessoa, Marta Martins, Sandra Casimiro, Carlos Pérez-Plasencia, Varda Shoshan-Barmatz   +4 more
doaj   +1 more source

Clinical patterns of thalidomide in the treatment of transfusion-dependent β-thalassaemia in children: a prospective single-arm study in China

Annals of Medicine
Background Previous studies in β-thalassaemia have shown that thalidomide is effective in reducing transfusion volume and is safe for short-term therapy of 6 months or less. The aim of this prospective study was to investigate long-term benefits and side
Xinyu Li, Weicong Hong, Jinni Wu, Qianyi Liu, Yong Liu, Shuting Hu, Luhong Xu, Honggui Xu, Danping Zhong, Junjiu Huang, Jianpei Fang   +10 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The 'Operational' Definition of Self-Control [PDF]

, 2018
Self-control is a hot topic across disciplines. As such, consensus on defining self-control is critical for advancing both scientific progress as well as societal impact of research findings.
Stress and self-regulation, Gillebaart, M., Marleen Gillebaart, Leerstoel Ridder   +3 more
core   +1 more source