Results 121 to 130 of about 25,321,967 (307)

Up-Regulation of hsa_circ_0000517 Predicts Adverse Prognosis of Hepatocellular Carcinoma

Frontiers in Oncology, 2019
Although huge progress has been made in therapeutics against hepatocellular carcinoma (HCC) over the decades, the prognosis of this lethal disease remains poor.
Xicheng Wang, Xicheng Wang, Xining Wang, Xining Wang, Wenxin Li, Wenxin Li, Qi Zhang, Jie Chen, Jie Chen, Tao Chen, Tao Chen   +10 more
doaj   +1 more source

Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors

The Journal of General Physiology, 2014
Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinson’s disease.
Brandon J. Henderson, Rahul Srinivasan, Weston A. Nichols, Crystal N. Dilworth, D. F. Gutiérrez, Elisha D. W. Mackey, S. McKinney, R. Drenan, Christopher I. Richards, H. Lester   +9 more
semanticscholar   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Digest of the handbook on electricity regulation [PDF]

Published online: November 2025This book is a companion volume to the Handbook on Electricity Markets, which focused on the evolution and challenges of wholesale electricity markets, particularly with the integration of intermittent renewable energy ...

core   +1 more source

Lysyl Oxidase-Like 1 (LOXL1) Up-Regulation in Chondrocytes Promotes M1 Macrophage Activation in Osteoarthritis via NF-κB and STAT3 Signaling

ImmunoTargets and Therapy
Yuyun Jiang,1,* Shang Wang,2,* Wei Zhu,1,3 Xi Liu,1 Yanwei Yang,1 Liyue Huo,1 Jixian Ye,1 Yongbin Ma,1,4 Yuepeng Zhou,1 Zhe Yang,1 Jiahui Mao,1 Xuefeng Wang1,5 1Department of Central Laboratory, The Affiliated Hospital of Jiangsu University ...
Jiang Y, Wang S, Zhu W, Liu X, Yang Y, Huo L, Ye J, Ma Y, Zhou Y, Yang Z, Mao J, Wang X   +11 more
doaj  

Up-regulation of MiR-21 in Oral Squamous Cell Carcinoma

Regeneration, Reconstruction & Restoration, 2018
Introduction: Oral squamous cell carcinoma (OSCC) is the most abundant dysplasia in the oral cavity that aberrant expression of microRNA plays an important role in cancer progression.
Mona Peyman, Hassan Mir Mohammad Sadeghi, Hakimeh Zali, Yousef Arianmehr, Solmaz Alihosseini, Farzad Yazdani, Saeed Hesami Tackallou   +6 more
doaj   +1 more source

Regulation of K+ Nutrition in Plants

Frontiers in Plant Science, 2019
Modern agriculture relies on mineral fertilization. Unlike other major macronutrients, potassium (K+) is not incorporated into organic matter but remains as soluble ion in the cell sap contributing up to 10% of the dry organic matter.
Paula Ragel, Natalia Raddatz, E. Leidi, Francisco J. Quintero, J. M. Pardo   +4 more
semanticscholar   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

PRICE REGULATION MODEL FOR POSTAL SERVICES

Perner’s Contacts, 2013
The method of price regulation of the domestic postal services within the regulation used in the Czech postal sector is not suitable. A more effective and more transparent method of price regulation of postal services would be the price-cap method which
Libor Švadlenka, Daniel Salava
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source