Results 121 to 130 of about 36,901 (236)

Units of fibrinolytic system in mice with urokinase gene knockout in presence of growing B16/F10 melanoma

Южно-Российский онкологический журнал
Purpose of the study. Was to reveal the effect of urokinase gene knockout in male and female mice with transplanted  B16/F10 melanoma on the functions of the fibrinolytic system units.Materials and methods. Male and female mice were used: main group with
E. M. Frantsiyants, V. A. Bandovkina, E. I. Surikova, I. V. Kaplieva, Yu. A. Pogorelova, I. V. Neskubina, L. K. Trepitaki, N. D. Cheryarina, N. D. Ushakova, O. G. Ishonina, M. A. Gusareva, I. A. Udalenkova   +11 more
doaj   +1 more source

Bedeutung von uPA und PAI-1 bei nodal-negativem Mammakarzinom

, 2011
Problem: uPA und PAI-1 werden als neue prognostische Faktoren beim nodal-neg. Mammakarzinom diskutiert. Hohe Konzentrationen korrelieren mit einem erhöhten Metastasierungsrisiko und einem kürzeren Gesamtüberleben bei nodal-neg. Tumoren. Methode: Bei 309
Streckert, Ilka
core   +1 more source

人uPA基因克隆和单克隆抗体的制备及其在乳腺癌中表达的检测

Zhongguo shiyan zhenduanxue, 2009
目的克隆人尿激酶型纤溶酶原激活物（urokinase-type plasminogen activator,uPA）基因,制备和鉴定针对人uPA的单克隆抗体,检测uPA在乳腺癌中的表达。方法利用RT-PCR方法从人乳腺癌细胞MDA231总RNA中扩增克隆uPA基因,构建可表达uPA蛋白的原核表达质粒,在大肠杆菌中诱导表达GST-His-uPA融合蛋白。以纯化的融合蛋白免疫Balb/c小鼠,取其脾细胞与小鼠骨髓瘤细胞（SP2/0）融合及次黄嘌呤、氨基蝶呤与胸苷选择性培养,并进行三次亚克隆筛选出单克隆细胞株,
赵桂梅, 张青云, 王雅明, 徐建军   +3 more
doaj  

Qualitative and quantitative agreement research on three diagnostic methods for maxillary transverse discrepancy

BMC Oral Health
Objective The purpose of this cross-sectional study is to compare the agreement of three diagnostic methods for maxillary transverse deficiency (MTD) across different skeletal malocclusion.
Zhang Ningbo, Wang Tianxiao, Yan Feng, Chen Rui, Fu Xinyu, Ren Liling   +5 more
doaj   +1 more source

Clinical Relevance of Urokinase-type Plasminogen Activator ( uPA ) , uPA Receptor , Plasminogen Activator Inhibitor-1 Co-expression from Tissue and Serum of Breast Cancer as Targets of Biotherapy

, 1999
Purpose: We measured and compared the uPA, plasminogen activator inhibitor-1 (PAI-1) and uPA receptor (uPAR) levels in breast cancer tissues and blood of the patients to evaluate their clinical relevance for biotherapy. Materials and Methods: uPA, PAI-1 (
라선영, 정현철, 노재경
core  

Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2011
Background and objective uPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer ...
Yanyi JIANG, Yizhen LIU, Zhizhou SHI, Boshi WANG, Li SHANG, Xin XU, Shengzhou ZHANG, Mingrong WANG   +7 more
doaj  

Real-World Use and Effectiveness Outcomes in Patients with Rheumatoid Arthritis Treated with Upadacitinib: An Analysis from the CorEvitas Registry

Rheumatology and Therapy
Introduction Data assessing longer-term real-world effectiveness and treatment patterns with upadacitinib (UPA), a Janus kinase inhibitor, in rheumatoid arthritis (RA) are lacking.
Joshua F. Baker, Patrick Zueger, Mira Ali, Denise Bennett, Miao Yu, Yolanda Munoz Maldonado, Robert R. McLean   +6 more
doaj   +1 more source

Correlation between P38 mitogen-activated protein kinase signal transduction pathway and uPA expression in ovarian cancer

Zhongguo aizheng zazhi, 2015
Background and purpose: P38 mitogen-activated protein kinase (P38MAPK) signal transduction pathway is involved in occurrence, development and transfer process in a wide variety of tumors. Urokinase-type plasminogen activator (uPA) plays an important role
邹存华, 王　宏, 宋冬冬
doaj  

Adipocytes derived fibrinolytic components in peritoneum — a pilot study

Open Medicine, 2012
Opatrna Sylvie, Korabečná Marie, Křížková Věra, Tonar Zbynek, Kočová Jitka, Mullerová Dana   +5 more
doaj   +1 more source

Cellular accumulation of uPA-PAI-1 [correction of UPA-PAI-1] and uPA-PAI-2 [correction of UPA-PAI-2] complexes in early (pT1) breast cancer: a new link in the uPA-UPAr-PAI chain.

In vivo (Athens, Greece), 2000
To investigate the role of uPA in early (pT1) breast cancer.Immunohistochemistry (streptavidin-biotin-peroxidase system), using the Chemicon AB776 polyclonal antibody, which reacts with uPA-PA-1 and uPA-PAI-2 complexes, was performed. In addition, CD44std, Ki67, c-erb-B2, p53, ER and PR expression were studied on the same tissue samples by the same ...
J, Schneider, R, Lucas, J, Sánchez, A, Tejerina, A, Ruibal   +4 more
openaire   +1 more source