Results 221 to 230 of about 14,579 (261)

Author Correction: Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease. [PDF]

Nat Commun
Elwakiel A, Gupta D, Rana R, Manoharan J, Al-Dabet MM, Ambreen S, Fatima S, Zimmermann S, Mathew A, Li Z, Singh K, Gupta A, Pal S, Sulaj A, Kopf S, Schwab C, Baber R, Geffers R, Götze T, Alo B, Lamers C, Kluge P, Kuenze G, Kohli S, Renné T, Shahzad K, Isermann B.   +26 more
europepmc   +1 more source

Rollen til urokinase plasminogen aktivator reseptoren (uPAR) for uttrykk av molekyler involvert i celle adhesjon, migrasjon og invasjon

, 2010
Stine-Mari Haustreis
openalex   +1 more source

The role of urokinase-type plasminogen activator receptor (uPAR) in corneal epithelial wound healing process.

, 2016
Shoko Hiraki, Koji Sugioka, Aya Kodama, Yoshikazu Shimomura   +3 more
openalex   +1 more source

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Regulation of cell signalling by uPAR

Nature Reviews Molecular Cell Biology, 2010
Urokinase-type plasminogen activator receptor (uPAR) expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. uPAR regulates proteolysis by binding the extracellular protease urokinase-type plasminogen activator (uPA; also known as urokinase) and also activates many ...
Harvey W Smith, Christopher J Marshall
exaly   +3 more sources

Development of inhibitors for uPAR: blocking the interaction of uPAR with its partners

Drug Discovery Today, 2021
Urokinase-type plasminogen activator receptor (uPAR) mediates a multitude of biological activities, has key roles in several clinical indications, including malignancies and inflammation, and, thus, has attracted intensive research over the past few decades.
Cai Yuan, Zhanzhi Guo, Shujuan Yu, Longguang Jiang, Mingdong Huang   +4 more
openaire   +2 more sources

uPAR: a versatile signalling orchestrator

Nature Reviews Molecular Cell Biology, 2002
The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a ...
Francesco, Blasi, Peter, Carmeliet
openaire   +2 more sources

Targeting uPA/uPAR in prostate cancer

Cancer Treatment Reviews, 2007
Prostate cancer (CaP) is one of the most common malignancies in men, with an increasing incidence. Despite significant advances in surgery, chemotherapy and radiotherapy to treat CaP, many patients unfortunately succumb to secondary disease (metastases).
Y, Li, P J, Cozzi
openaire   +2 more sources

uPA and uPAR in fibrinolysis, immunity and pathology

Trends in Immunology, 2004
Abstract The urokinase plasminogen activator (uPA) and its receptor (uPAR) exert pleiotropic functions over the course of both physiological and pathological processes. Data generated in deficient mice have underlined how uPA not only has a key role in fibrinolysis but also modulates the development of protective immunity.
Anna, Mondino, Francesco, Blasi
openaire   +2 more sources

uPAR in angiogenesis regulation

Blood, 2011
In this issue of Blood , Brunner and colleagues demonstrate that uPAR, the urokinase plasminogen activator (uPA) receptor that drives endothelial invasion and proliferation in the initial phases of angiogenesis, undergoes down-regulation by density-enhanced phosphatase-1 (DEP-1) in ...
openaire   +2 more sources