Results 231 to 240 of about 14,579 (261)
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Thrombosis and Haemostasis, 2013
doi:10.1160/TH13-01-0001 Thromb Haemost 2013; 109: 179 TH 109: 309-318. Transmembrane proteins usually relay signals to the cytoplasm and nucleus via their intracellular domains. Nonetheless, this paradigm is challenged by glycosylphosphatidylinositol (GPI)-anchored proteins.
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doi:10.1160/TH13-01-0001 Thromb Haemost 2013; 109: 179 TH 109: 309-318. Transmembrane proteins usually relay signals to the cytoplasm and nucleus via their intracellular domains. Nonetheless, this paradigm is challenged by glycosylphosphatidylinositol (GPI)-anchored proteins.
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Role of uPA/uPAR in the Modulation of Angiogenesis
2013Blood vessels connect all districts of the body and allow blood oxygen and nutrients to reach every cell in the organism. Dysregulation of blood vessel formation or functionality is the origin of a large number of diseases. During new vessel formation, endothelial cells degrade their basement membrane, migrate into the interstitial matrix and ...
MONTUORI, NUNZIA, P. Ragno
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uPAR (CD87) as a Biocompatibility Marker of Dialysis Membrane
Blood Purification, 2006<i>Background/Aims:</i> Hemodialysis (HD) therapy may lead to functional changes in patient leukocytes. For example, the upregulation of inflammatory cytokines, such as IL-1β and TNFα, has been well characterized. However, these findings do not explain the entire response of leukocytes in HD.
Takayuki, Sohka +12 more
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Structure and ligand interactions of the urokinase receptor (uPAR)
Frontiers in Bioscience, 2008The urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycolipid-anchored membrane glycoprotein, which is responsible for focalizing plasminogen activation to the cell surface through its high-affinity binding to the serine protease uPA.
Kjærgaard, Magnus +4 more
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uPAR and Proteases in Mobilization of Hematopoietic Stem Cells
2008The specific cell-surface receptor for the urokinase-type plasminogen activator (uPA) was identified in 1985; since then, a large body of evidence showed that urokinase-type plasminogen activator receptor (uPAR) was not only the receptor for a proteolytic enzyme but also a multifunctional signaling molecule capable of various interactions and ...
RAGNO, Pia, FRANCESCO BLASI
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Development of Cyclic Peptide‐Based Radiotracers for uPAR
ChemMedChemAbstractThe urokinase plasminogen activator (uPA) system has garnered attention as a promising biomarker, with the uPA receptor (uPAR) playing a central role in system regulation and demonstrating strong associations with tumorigenicity, invasion, and metastasis.
Xingkai Wang +9 more
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Measuring uPAR Dynamics in Live Cells
2008Urokinase-type plasminogen activator receptor (uPAR) is a key component of the urokinase plasminogen activation (uPA) system, which plays important roles in physiological processes as well as in tumor invasion and metastasis. Besides uPAR’s well-established role in the regulation of pericellular proteolysis, a large body of evidences suggests that ...
Moreno Zamai +2 more
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ID: 86 Structural basis of uPAR-uPA and uPAR-vitronectin interactions
Journal of Thrombosis and Haemostasis, 2006M. Huang +9 more
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The uPA/uPAR pathway in the human heart
2015Background: Heart disease is still one of the leading death causes in humans. Myocardial infarction is accompanied with tremendous loss and death of human cardiac myocytes (HACM). The loss is associated with myocardial damage leading to heart failure.
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