Results 1 to 10 of about 8,610 (171)

Human uracil DNA N-glycosidase: studies in normal and repair defective cultured fibroblasts

Nucleic Acids Research, 1978
Uracil DNA N-glycosidase, an enzyme which participates in the excision of uracil from DNA, was measured in extracts from fibroblasts lines cultured from normal subjects, from several subjects with the genetic disease xeroderma pigmentosum, and from a subject with ataxia telangiectasia.
U, Kuhnlein, B, Lee, S, Linn
openaire   +4 more sources

Enzymes from Micrococcus luteus involved in the initial steps of excision repair of spontaneous DNA lesions: uracil-DNA-glycosidase and apurinic-endonucleases

Nucleic Acids Research, 1978
Uracil-DNA-glycosidase that releases free uracil from single-stranded or double-stranded deaminated DNA and poly d(A-U) has been partially purified from Micrococcus luteus. The enzyme has a molecular weight of about 16,000 and can be separated from uracil-endonuclease and endonucleases (AP-endonucleases) specific for apurinic and apyrimidinic sites ...
N V, Tomlin, O N, Aprelikova, L S, Barenfeld   +2 more
openaire   +4 more sources

UNG (Uracil-DNA-Glycosidase) [PDF]

Springer Reference Medizin, 2018
J. Arnemann
openaire   +3 more sources

Programmable DNA pyrimidine base editing via engineered uracil-DNA glycosylase. [PDF]

Nat Commun
DNA base editing technologies predominantly utilize engineered deaminases, limiting their ability to edit thymine and guanine directly. In this study, we successfully achieve base editing of both cytidine and thymine by leveraging the translesion DNA ...
Yi Z, Zhang X, Wei X, Li J, Ren J, Zhang X, Zhang Y, Tang H, Chang X, Yu Y, Wei W.   +10 more
europepmc   +2 more sources

DNA N-glycosidases: properties of uracil-DNA glycosidase from Escherichia coli.

Journal of Biological Chemistry, 1977
T, Lindahl, S, Ljungquist, W, Siegert, B, Nyberg, B, Sperens   +4 more
openaire   +3 more sources

Unprocessed genomic uracil as a source of DNA replication stress in cancer cells. [PDF]

Mol Cell
Alterations of bases in DNA constitute a major source of genomic instability. It is believed that base alterations trigger base excision repair (BER), generating DNA repair intermediates interfering with DNA replication. Here, we show that genomic uracil,
Saxena S, Nabel CS, Seay TW, Patel PS, Kawale AS, Crosby CR, Tigro H, Oh E, Vander Heiden MG, Hata AN, Suo Z, Zou L.   +11 more
europepmc   +2 more sources

Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity. [PDF]

DNA Repair (Amst), 2023
Mu Y, Zelazowska MA, Chen Z, Plummer JB, Dong Q, Krug LT, McBride KM.   +6 more
europepmc   +2 more sources

Removal of Misincorporated Ribonucleotides from Prokaryotic Genomes: An Unexpected Role for Nucleotide Excision Repair [PDF]

, 2013
Stringent steric exclusion mechanisms limit the misincorporation of ribonucleotides by high-fidelity DNA polymerases into genomic DNA. In contrast, low-fidelity Escherichia coli DNA polymerase V (pol V) has relatively poor sugar discrimination and ...
A Vaisman, AL Lu, Alexandra Vaisman, AR Fernández de Henestrosa, B Hiller, B Rydberg, B Van Houten, BD Davis, Bennett Van Houten, D Mu, DJ Crowley, DL Croteau, DL Croteau, DM Maron, Donald Huston, E Curti, E Wolff, EA Kouzminova, EF DeRose, EG Frank, EG Frank, EW Hou, F Lazzaro, G Churchward, G Jiang, GF Moolenaar, H Krokan, H Ohmori, H Shinagawa, H Wang, IJ Fijalkowska, J Yang, JA Brown, JB Sweasy, JC Huang, JE Sale, JG Moggs, JJ Lin, JJ Truglio, JL Sparks, John P. McDonald, JP McDonald, K Sugasawa, L Garibyan, L Zheng, LA Christensen, Lili Liu, M Sandigursky, M Skorvaga, M Tang, M Watanabe-Akanuma, M Yamaguchi, MA Reijns, MC Wahl, ME Branum, MM Ghodgaonkar, MR Albertella, N Kim, Q Jiang, Q Ruan, R Cone, R Woodgate, RJ Sanderson, Roger Woodgate, RP Cunningham, SA Lujan, SA Nick McElhinny, SA Nick McElhinny, Sue Jinks-Robertson, T Baba, T Lindahl, T Lindahl, T Nakano, W Kuban, W Yang, Wojciech Kuban, Y Shen, YW Kow   +77 more
core   +7 more sources

Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. [PDF]

, 2015
MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a
Cao, Sheng, Chu, Aurea, David, Sheila S, Horvath, Martin P, O'Shea, Valerie L, Richards, Jody L, Woods, Ryan D   +6 more
core   +2 more sources

Detection of uracil within DNA using a sensitive labeling method for in vitro and cellular applications [PDF]

, 2016
The role of uracil in genomic DNA has been recently re-evaluated. It is now widely accepted to be a physiologically important DNA element in diverse systems from specific phages to antibody maturation and Drosophila development.
Borsos, Máté, Békési, Angéla, Nagy, Kinga, Pálinkás, Hajnalka Laura, Róna, Gergely, Scheer, Ildikó, Tihanyi, Gergely, Vértessy, Beáta G.   +7 more
core   +1 more source