Results 31 to 40 of about 1,064 (75)
Detection of uracil within DNA using a sensitive labeling method for in vitro and cellular applications [PDF]
, 2016 The role of uracil in genomic DNA has been recently re-evaluated. It is now widely accepted to be a physiologically important DNA element in diverse systems from specific phages to antibody maturation and Drosophila development.
Borsos, Máté +7 more
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Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology
Journal of Analytical Methods in Chemistry, Volume 2016, Issue 1, 2016., 2016 Diosgenin, a steroidal sapogenin, occurs abundantly in plants such as Dioscorea alata, Smilax China, and Trigonella foenum graecum. This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has revealed also high potential and interest in the ...
Mafalda Jesus +4 more
wiley +1 more source
The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities [PDF]
, 2002 Saporin-6 produced by the plant Saponaria officinalis belongs to the family of single chain ribosome-inactivating proteins. It potently inhibits protein synthesis in eukaryotic cells, by cleaving the N-glycosidic bond of a specific adenine in 28 S rRNA ...
Bagga, Shveta +2 more
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Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy
ChemPlusChem, EarlyView.Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber +3 more
wiley +1 more source
Scientifica, Volume 2013, Issue 1, 2013., 2013 Type I interferon (IFN‐I) play a critical role in the innate immune response against viral infections. They actively participate in antiviral immunity by inducing molecular mechanisms of viral restriction and by limiting the spread of the infection, but they also orchestrate the initial phases of the adaptive immune response and influence the quality ...
Adriano Boasso, G. Chen, M. Clementi
wiley +1 more source
Stimuli‐Responsive Silica Silanol Conjugates: Strategic Nanoarchitectonics in Targeted Drug Delivery
Small, Volume 20, Issue 39, September 26, 2024.The silica surface silanol chemistry and its conjugation to different cargos through stimuli‐responsive linkers are highly desired. This review elucidates silica's surface chemistry, types of silanols, silanol number and chemistry, chemical and physical identification, functionalization, and stimuli‐responsive for precise drug delivery systems ...
Shan Mohanan +4 more
wiley +1 more source
Prodrugs for Gene‐Directed Enzyme‐Prodrug Therapy (Suicide Gene Therapy)
BioMed Research International, Volume 2003, Issue 1, Page 48-70, 2003., 2003 This review focuses on the prodrugs used in suicide gene therapy. These prodrugs need to satisfy a number of criteria. They must be efficient and selective substrates for the activating enzyme, and be metabolized to potent cytotoxins preferably able to kill cells at all stages of the cell cycle.
William A. Denny
wiley +1 more source
Genetic tools for Sulfolobus spp.: vectors and first applications [PDF]
, 2018 Sulfolobus species belong to the best-studied archaeal organisms but have lacked powerful genetic methods. Recently, there has been considerable progress in the field of Sulfolobus genetics.
Berkner, Silvia, Lipps, Georg
core
RNA methylation‐related inhibitors: Biological basis and therapeutic potential for cancer therapy
Clinical and Translational Medicine, Volume 14, Issue 4, April 2024.In this review, several common types of RNA modifications are reviewed, and the role of regulatory factors related to these modifications in cancer progression is discussed. Finally, the latest advances in small molecule inhibitors of these regulatory factors are especially reviewed. Abstract RNA methylation is widespread in nature. Abnormal expression
Huanxiang Chen +9 more
wiley +1 more source
Studies of Trans-N-Glycosidase of Thermobacter Acidophilus and its Inhibition by 6-Azathymidine [PDF]
, 1959 [From the Introduction] The purpose of this investigation was to purify the enzyme trans-N-glycosidase from T. acidophilus and to study its specificity, optimum pH, and the effect of various other compounds, particularly azathymine and azathymidine, upon
Marsh, John C.
core +1 more source