Results 91 to 100 of about 22,001 (241)

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway [PDF]

, 2004
In nucleotide incision repair (NIR), an endonuclease nicks oxidatively damaged DNA in a DNA glycosylase-independent manner, providing the correct ends for DNA synthesis coupled to the repair of the remaining 5'-dangling modified nucleotide.
Elder, RH, Gros, L, Ide, H, Ishchenko, AA, Saparbaev, MK   +4 more
core   +5 more sources

Telomere maintenance: regulating hTERC fate through RNA modifications

Molecular & Cellular Oncology, 2019
Disturbances in telomere maintenance are common in cancer. We recently showed that Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) promotes telomere homeostasis by regulating the stability of the telomeric RNA component (hTERC ...
Lisa Lirussi, Hilde Nilsen
doaj   +1 more source

Engineering of Peptide‐Inserted Base Editors with Enhanced Accuracy and Security

Small, Volume 21, Issue 14, April 9, 2025.
This work developed a novel peptide insertion strategy to enhance the performance of base editors. Through changing the composition and position of the inserted peptide, peptide‐inserted base editors are engineered to exhibit robust on‐target editing activity and improved precision.
Qi Chen, Yangning Sun, Jia Yao, Yingfan Lu, Ruikang Qiu, Fuling Zhou, Zixin Deng, Yuhui Sun   +7 more
wiley   +1 more source

Uracil Accumulation Response To Folate Depletion Is A Function Of Dna Repair Imbalance That May Be A Mechanism Of Aging [PDF]

, 2014
Folate is an essential nutrient for human. They carry and transfer one carbon units. They has important biological functions during many reactions, like DNA synthesis, RNA synthesis, DNA methylation, DNA repair, cell division and growth.
Ma, Hongzhi
core   +1 more source

Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms [PDF]

FEMS Microbiology Letters, 1996
Hyperthermophiles exist in conditions which present an increased threat to the informational integrity of their DNA, particularly by hydrolytic damage. As in mesophilic organisms, specific activities must exist to restore and protect this template function of DNA.
Don A. Cowan, Laurence H. Pearl, Renos Savva, Athanasios Koulis   +3 more
openaire   +3 more sources

A Post‐Mortem Molecular Damage Profile in the Ancient Human Mitochondrial DNA

Molecular Ecology Resources, Volume 25, Issue 4, May 2025.
ABSTRACT Mitochondrial DNA (mtDNA) analysis is crucial for understanding human population structure and genetic diversity. However, post‐mortem DNA damage poses challenges, that make analysis difficult. DNA preservation is affected by environmental conditions which, among other factors, complicates the differentiation of endogenous variants from ...
Daniel R. Cuesta‐Aguirre, Cristina Amor‐Jimenez, Assumpció Malgosa, Cristina Santos   +3 more
wiley   +1 more source

The Influence of (5′R)- and (5′S)-5′,8-Cyclo-2′-Deoxyadenosine on UDG and hAPE1 Activity. Tandem Lesions are the Base Excision Repair System’s Nightmare

Cells, 2019
DNA lesions are formed continuously in each living cell as a result of environmental factors, ionisation radiation, metabolic processes, etc. Most lesions are removed from the genome by the base excision repair system (BER).
Bolesław T. Karwowski
doaj   +1 more source

Uracil-DNA glycosylase as a probe for protein-DNA interactions [PDF]

Nucleic Acids Research, 1993
The DNA repair enzyme Uracil-DNA Glycosylase (UDG) can be used to investigate three different features of protein-DNA interactions. Complexes can be probed by simple protection experiments ('footprinting') or by two kinds of interference assays: a missing thymine site (MT-site) experiment and a missing thymine methyl site (MTM-site) experiment.
Pallavi R. Devchand, John H. van de Sande, James D. McGhee   +2 more
openaire   +3 more sources

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

The FEBS Journal, EarlyView.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres, Carlos H. Trasviña‐Arenas, Alexandru Ionut Gilea, Upeksha C. Dissanayake, Missael Molina‐Jiménez, Paola L. García‐Medel, Corina Díaz‐Quezada, Tiziana Lodi, G. Andrés Cisneros, Enrico Baruffini, Luis G. Brieba   +10 more
wiley   +1 more source