Results 91 to 100 of about 24,501 (233)
Evasion of APOBEC1-mediated Intrinsic Immunity by a Herpesvirus Uracil DNA Glycosylase Is a Determinant of Viral Encephalitis [PDF]
, 2023 Akihisa Kato +14 more
openalex +1 more source
A Field‐Deployable RotEx‐LAMP‐LFA Platform for Molecular Triage of HPV‐Driven Oncogenesis
Advanced Science, Volume 12, Issue 47, December 18, 2025.This study presents RotEx‐LAMP‐LFA, a fully integrated, battery‐powered, low‐cost point‐of‐care device for rapid cervical cancer risk detection based on HPV16/18 E6/E7 mRNA. Clinically validated, the system demonstrated high sensitivity and specificity, and showed full concordance between self‐collected and clinician‐collected samples, offering a ...
Yuan Gao +10 more
wiley +1 more source
Distinct Phage‐Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes
Advanced Science, Volume 12, Issue 46, December 11, 2025.Distinct enzymes including dCTP deaminases (Dcds), dTMP phosphatases (Dtms), and dTTP pyrophosphatases (Dtt) are found to be responsible for dU‐DNA biosynthesis in the phages PBS1, DSS3_VP1, and PhiR1‐37. Both PhiR1‐37‐derived and synthetic dU‐DNA are resistant to cleavage by restriction enzymes and Cas12a nuclease targeting dT‐containing sites.
Yating Li +7 more
wiley +1 more source
Advanced Science, Volume 12, Issue 47, December 18, 2025.Susceptibility to the health effects of DNA damage depends on a person's ability to repair DNA damage, but DNA repair has been difficult to measure in populations. A functional assay called FM‐HCR is used to measure DNA repair in 6 major pathways across 56 individuals.
Ting Zhai +7 more
wiley +1 more source
BioTechniques, 2005 PCR analyses of ancient and degraded DNA suffer from their extreme sensitivity to contamination by modern DNA originating, in particular, from carryover contamination with previously amplified or cloned material.
Mélanie Pruvost +2 more
doaj +1 more source
Loss of Uracil DNA Glycosylase Selectively Resensitizes p53-Mutant and -Deficient Cells to 5-FdU
Molecular Cancer Research, 2017 Thymidylate synthase (TS) inhibitors including fluoropyrimidines [e.g., 5-Fluorouracil (5-FU) and 5-Fluorodeoxyuridine (5-FdU, floxuridine)] and antifolates (e.g., pemetrexed) are widely used against solid tumors.
Yan Yan, Yulan Qing, J. Pink, S. Gerson
semanticscholar +1 more source
Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil.
PLoS Biology, 2009 5-Fluorouracil (5-FU), a chemotherapeutic drug commonly used in cancer treatment, imbalances nucleotide pools, thereby favoring misincorporation of uracil and 5-FU into genomic DNA.
Christophe Kunz +6 more
doaj +1 more source
Scientific Reports, 2016 Tembusu virus (TMUV) is a mosquito-borne flavivirus which threatens both poultry production and public health. In this study we developed a complete open reading frame alignment-based rRT-LAMP method for the universal detection of TUMV.
Yi Tang, Hao Chen, Y. Diao
semanticscholar +1 more source
UGI relocation inside Cas9 reduces Cas9 dependent off target effects in cytosine base editors
Scientific ReportsCytosine base editors (CBEs) achieve precise C-to-T conversions by addition of uracil DNA glycosylase inhibitor (UGI) with Cas9 nickase (nCas9) and cytidine deaminase, and the conventional fusion at the nCas9 carboxyl terminus effectively inhibits uracil
Zehao Shi, Tian-Lin Cheng
doaj +1 more source
Oxidative Medicine and Cellular Longevity, 2018 Leishmania donovani is an intracellular protozoan parasite that causes endemic tropical disease visceral leishmaniasis (VL). Present drugs used against this fatal disease are facing resistance and toxicity issues.
Anshul Mishra +7 more
semanticscholar +1 more source