Results 211 to 220 of about 22,001 (241)

Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein Semisynthesis. [PDF]

Biophys J, 2017
Weiser BP, Stivers JT, Cole PA.
europepmc   +1 more source

N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions. [PDF]

Nucleic Acids Res, 2018
Weiser BP, Rodriguez G, Cole PA, Stivers JT.   +3 more
europepmc   +1 more source

Oxidative Stress-Mediated Overexpression of Uracil DNA Glycosylase in Leishmania donovani Confers Tolerance against Antileishmanial Drugs. [PDF]

Oxid Med Cell Longev, 2018
Mishra A, Khan MI, Jha PK, Kumar A, Das S, Das P, Das P, Sinha KK.   +7 more
europepmc   +1 more source

Uracil-DNA glycosylase acts by substrate autocatalysis [PDF]

Nature, 2001
In humans, uracil appears in DNA at the rate of several hundred bases per cell each day as a result of misincorporation of deoxyuridine (dU) or deamination of cytosine. Four enzymes that catalyse the hydrolysis of the glycosylic bond of dU in DNA to yield an apyridiminic site as the first step in base excision repair have been identified in the human ...
G. Michael Blackburn, Aaron R. Dinner, Aaron R. Dinner, Martin Karplus, Martin Karplus   +4 more
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Processivity of uracil DNA glycosylase

Mutation Research/DNA Repair, 1993
The purpose of this study was to determine the mechanism by which uracil DNA glycosylase locates uracil residues within double-stranded DNA. Using reaction conditions that contained low salt concentrations, the addition of uracil DNA glycosylase to plasmid DNAs containing multiple, randomly incorporated uracils resulted in the accumulation of form III ...
R. Stephen Lloyd, Michelle Higley
openaire   +3 more sources

Complexes of the uracil-DNA glycosylase inhibitor protein, Ugi, with Mycobacterium smegmatis and Mycobacterium tuberculosis uracil-DNA glycosylases

Microbiology, 2003
Uracil, a promutagenic base, appears in DNA either by deamination of cytosine or by incorporation of dUMP by DNA polymerases. This unconventional base in DNA is removed by uracil-DNA glycosylase (UDG). Interestingly, a bacteriophage-encoded short polypeptide, UDG inhibitor (Ugi), specifically inhibits UDGs by forming a tight complex.
Acharya, Narottam, Kumar, Pradeep, Varshney, Umesh   +2 more
openaire   +3 more sources

Mutational Analysis of the Uracil DNA Glycosylase Inhibitor Protein and Its Interaction with Escherichia coli Uracil DNA Glycosylase

Journal of Molecular Biology, 2002
Uracil DNA glycosylase inhibitor (Ugi), a protein of 9.4 kDa consists of a five-stranded antiparallel beta sheet flanked on either side by single alpha helices, forms an exclusive complex with uracil DNA glycosylases (UDGs) that is stable in 8M urea. We report on the mutational analysis of various structural elements in Ugi, two of which (hydrophobic ...
Acharya, Narottam, Roy, Sudipta, Varshney, Umesh   +2 more
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Uracil-DNA Glycosylases and DNA Uracil Repair

1989
Publisher Summary This chapter reviews the DNA uracil repair and uracil–DNA glycosylases (UDG). The major source of DNA uracil in prokaryotic and eukaryotic cells is transient incorporation of dUMP during replication. This replicative uracil is quickly repaired by UDG, apyramidinic/apurinic (AP) endonucleases, and other enzymes of excision repair ...
O.N. Aprelikova, N.V. Tomilin
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URACIL-DNA GLYCOSYLASE MUTANTS ARE MUTATORS

1978
ABSTRACT Spontaneous mutation to nalidixic acid or to rifampicin resistance is increased 5-fold in uracil-DNA glycosylase ( ung ) mutants of E. coli. By trpA reversion analysis we observed a 15-fold increase in the frequency of spontaneous G:C→A:T transition mutations while other transition and transversion frequencies were not affected.
Bernard Weiss, Bruce K. Duncan
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Structure and function in the uracil-DNA glycosylase superfamily

Mutation Research/DNA Repair, 2000
Deamination of cytosine to uracil is one of the major pro-mutagenic events in DNA, causing G:C-->A:T transition mutations if not repaired before replication. Repair of uracil-DNA is achieved in a base-excision pathway initiated by a uracil-DNA glycosylase (UDG) enzyme of which four families have so far been identified.
openaire   +3 more sources