Results 21 to 30 of about 24,501 (233)

N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA–dsDNA junctions [PDF]

Nucleic Acids Research, 2018
The N-terminal domain (NTD) of nuclear human uracil DNA glycosylase (hUNG2) assists in targeting hUNG2 to replication forks through specific interactions with replication protein A (RPA).
Brian P. Weiser, Gaddiel Rodriguez, P. Cole, J. Stivers   +3 more
semanticscholar   +2 more sources

Utility of blood as the clinical specimen for the diagnosis of ocular toxoplasmosis using uracil DNA glycosylase-supplemented loop-mediated isothermal amplification and real-time polymerase chain reaction assays based on REP-529 sequence and B1 gene. [PDF]

BMC Infect Dis, 2022
Rahimi Esboei B, Fallahi S, Zarei M, Kazemi B, Mohebali M, Shojaee S, Mousavi P, Teimouri A, Mahmoudzadeh R, Salabati M, Keshavarz Valian H.   +10 more
europepmc   +3 more sources

Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic

Molecular Cancer, 2004
Background Uracil DNA glycosylase (UDG) plays a major role in repair of uracil formed due to deamination of cytosine. UDG in human cells is present in both the nucleus and mitochondrial compartments.
Singh Keshav K, Kachhap Sushant
doaj   +3 more sources

Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells. [PDF]

Nucleic Acids Res, 2017
DNA ‘sliding’ by human repair enzymes is considered to be important for DNA damage detection. Here, we transfected uracil-containing DNA duplexes into human cells and measured the probability that nuclear human uracil DNA glycosylase (hUNG2) excised two ...
Esadze A, Rodriguez G, Weiser BP, Cole PA, Stivers JT.   +4 more
europepmc   +2 more sources

Escherichia coli DNA repair helicase Lhr is also a uracil-DNA glycosylase. [PDF]

Mol Microbiol, 2023
Buckley RJ, Lou-Hing A, Hanson KM, Ahmed NR, Cooper CDO, Bolt EL.   +5 more
europepmc   +3 more sources

Uracil-DNA Glycosylase from <i>Beta vulgaris</i>: Properties and Response to Abiotic Stress. [PDF]

Int J Mol Sci
Petrova DV, Zateeva MV, Zhang L, Zhang J, Zhao Y, Permyakova NV, Zagorskaya AA, Zharkov VD, Endutkin AV, Yu B, Ma C, Li H, Zharkov DO, Grin IR.   +13 more
europepmc   +3 more sources

An Intelligent Allosteric DNAzyme Platform for On-Site Uracil-DNA Glycosylase Imaging and On-Demand Gene Regulation. [PDF]

JACS Au
Jiang Y, Chen Y, Gong X, Weng B, He Y, Wang F.   +5 more
europepmc   +2 more sources

Correlated Mutation in the Evolution of Catalysis in Uracil DNA Glycosylase Superfamily. [PDF]

Sci Rep, 2017
Xia B, Liu Y, Guevara J, Li J, Jilich C, Yang Y, Wang L, Dominy BN, Cao W.   +8 more
europepmc   +3 more sources

A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine. [PDF]

PLoS ONE, 2014
We demonstrate that a mutant of uracil DNA glycosylase (N123D:L191A) distinguishes between cytosine and methylcytosine. Uracil DNA glycosylase (UDG) efficiently removes uracil from DNA in a reaction in which the base is flipped into the enzyme's active ...
Scott T Kimber, Tom Brown, Keith R Fox
doaj   +1 more source

Viruses with U-DNA: New Avenues for Biotechnology

Viruses, 2021
Deoxyuridine in DNA has recently been in the focus of research due to its intriguing roles in several physiological and pathophysiological situations. Although not an orthodox DNA base, uracil may appear in DNA via either cytosine deamination or thymine ...
Kinga K. Nagy, Mikael Skurnik, Beáta G. Vértessy   +2 more
doaj   +1 more source