Results 51 to 60 of about 22,001 (241)

Replication Protein A (RPA) Targeting of Uracil DNA Glycosylase (UNG2) [PDF]

, 2021
Replication Protein A (RPA) is a single stranded DNA binding protein which stabilizes ssDNA for replication and repair. One function of RPA is to bind the DNA repair enzyme uracil DNA glycosylase (UNG2) and direct its activity towards ssDNA dsDNA ...
Chen, Derek, Weiser, Brian P
core   +1 more source

Uracil-DNA Glycosylase Inhibitor Gene of Bacteriophage PBS2 Encodes a Binding Protein Specific for Uracil-DNA Glycosylase

Journal of Biological Chemistry, 1989
The uracil-DNA glycosylase inhibitor gene (ugi) of the Bacillus subtilis bacteriophage PBS2 has been subcloned to a 720-base pair DNA fragment contained in pZW2-0.7 and its nucleotide sequence determined. Using nucleotide deletion analysis, we have located the cloned ugi gene along with potential regulatory elements. A promoter-like region (-10 and -35
Zhigang Wang, D. W. Mosbaugh
openaire   +3 more sources

Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA [PDF]

, 2009
DNA sequences determined from ancient organisms have high error rates, primarily due to uracil bases created by cytosine deamination. We use synthetic oligonucleotides, as well as DNA extracted from mammoth and Neandertal remains, to show that treatment ...
Briggs, Adrian W., Kircher, Martin, Krause, Johannes, Meyer, Matthias, Pääbo, Svante, Stenzel, Udo   +5 more
core   +4 more sources

RNA Metabolism Guided by RNA Modifications: The Role of SMUG1 in rRNA Quality Control

Biomolecules, 2021
RNA modifications are essential for proper RNA processing, quality control, and maturation steps. In the last decade, some eukaryotic DNA repair enzymes have been shown to have an ability to recognize and process modified RNA substrates and thereby ...
Lisa Lirussi, Özlem Demir, Panpan You, Antonio Sarno, Rommie E. Amaro, Hilde Nilsen   +5 more
doaj   +1 more source

The HIV-1 Protein Vpr Targets the Endoribonuclease Dicer for Proteasomal Degradation to Boost Macrophage Infection [PDF]

, 2013
The HIV-1 protein Vpr enhances macrophage infection, triggers G2 cell cycle arrest, and targets cells for NK-cell killing. Vpr acts through the CRL4DCAF1 ubiquitin ligase complex to cause G2 arrest and trigger expression of NK ligands.
de Noronha, Carlos M.C., Flagg, Meg, Furuya, Andrea K.M., Klockow, Laurieann, Nekorchuk, Michael, Sharifi, Hamayun J., Wen, Xiaoyun   +6 more
core   +2 more sources

Biochemical characterization and novel inhibitor identification of Mycobacterium tuberculosis Endonuclease VIII 2 (Rv3297)

Biochemistry and Biophysics Reports, 2017
Nei2 (Rv3297) is a DNA Base Excision Repair (BER) glycosylase that is essential for survival of Mycobacterium tuberculosis in primates. We show that MtbNei2 is a bifunctional glycosylase that specifically acts on oxidized pyrimidine-containing single ...
Kiran Lata, Mohammad Afsar, Ravishankar Ramachandran   +2 more
doaj   +1 more source

Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA. [PDF]

PLoS Pathogens, 2013
The covalently closed circular DNA (cccDNA) of the hepatitis B virus (HBV) plays an essential role in chronic hepatitis. The cellular repair system is proposed to convert cytoplasmic nucleocapsid (NC) DNA (partially double-stranded DNA) into cccDNA in ...
Kouichi Kitamura, Zhe Wang, Sajeda Chowdhury, Miyuki Simadu, Miki Koura, Masamichi Muramatsu   +5 more
doaj   +1 more source

Advancing Precision Medicine: Recent Innovations in Gene Editing Technologies

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This review article delves into the cutting‐edge advancements in gene editing technology, with a particular focus on prime editor proteins and their engineered variants. The authors provide a thorough examination of recent developments that have addressed key challenges in the field, including improved precision, enhanced editing efficiency, and ...
Abhijith Koodamvetty, Saravanabhavan Thangavel   +1 more
wiley   +1 more source

Sequence Context‐Agnostic TadA‐Derived Cytosine Base Editors for Genome‐Wide Editing in Zebrafish

Advanced Science, Volume 12, Issue 14, April 10, 2025.
zTadA‐CBEs, developed by introducing key mutations into TadA8e, enable efficient and precise sequence context‐agnostic cytosine base editing. Specifically, zTadA‐BE4max and zTadA‐BEmv provide complementary editing windows, while zTadA‐SpRY‐BE4max offers PAM‐flexible editing.
Shaohui Zheng, Yang Liu, Xinxin Xia, Jiawang Xiao, Hui Ma, Xuanyao Yuan, Yan Zhang, Zixi Chen, Guangcong Peng, Wenyuan Li, Ji‐Feng Fei, Yanmei Liu   +11 more
wiley   +1 more source

Mechanisms of base selection by the E.coli mispaired uracil glycosylase [PDF]

, 2008
The repair of the multitude of single-base lesions formed daily in the cells of all living organisms is accomplished primarily by the base-excision repair (BER) pathway that initiates repair through a series of lesion-selective glycosylases.
Darwanto, Agus, Goddard, William, III, Liu, Pingfang, Pascal, Tod, Sowers, Lawrence C., Theruvathu, Jacob A., Valinluck Lao, Victoria   +6 more
core   +2 more sources