Results 61 to 70 of about 22,001 (241)

Functional analysis on a naturally occurring variant of the Staphylococcus Aureus uracil DNA Glycosylase inhibitor [PDF]

, 2017
Repair of DNA damage relies on various pathways including the base excision repair (BER) which targets erroneous bases in the DNA. Here, Uracil-DNA glycosylases (UDGs) are responsible for recognition and removal of uracil base from the DNA.
Balázs, Zoltán, G. Vértessy, Beáta, Juhász, Tünde, Liliom, Károly, Nagy, Gergely N., Papp-Kádár, Veronika   +5 more
core   +2 more sources

A common SNP in the UNG gene decreases ovarian cancer risk in BRCA2 mutation carriers

Molecular Oncology, 2019
Single nucleotide polymorphisms (SNPs) in DNA glycosylase genes involved in the base excision repair (BER) pathway can modify breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
Juan Miguel Baquero, Carlos Benítez‐Buelga, Victoria Fernández, Miguel Urioste, Jose Luis García‐Giménez, Rosario Perona, the CIMBA Consortium, Javier Benítez, Ana Osorio   +8 more
doaj   +1 more source

Action mechanism of human SMUG1 uracil-DNA glycosylase [PDF]

Nucleic Acids Symposium Series, 2005
The DNA lesions resulting from deamination or oxidation of bases are generally repaired by the base excision repair pathway initiated by damage-specific DNA glycosylases. Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) present in vertebrates and insects excises not only uracil but also uracil derivatives bearing an oxidized group ...
Hiroshi Ide, Mayumi Matsubara, Hiroaki Terato, Tamon Tanaka   +3 more
openaire   +3 more sources

Plasma DNMT1 Activity for Assessing Tumor Burden and Predicting Neoadjuvant Therapy Response in Breast Cancer

Advanced Science, EarlyView.
In this work, a detection method is presented for the activity of plasma DNA methyltransferase 1 (DNMT1), namely DNMT1 Identification by Variable Activity (DIVA). DIVA can detect plasma DNMT1 at levels as low as 10−7 U mL−1, also it successfully evaluated tumor burden and predicted the neoadjuvant therapy responses of breast cancer patients.
Yingran Wang, Guozhi Zhang, Zhizhao Zhang, Mengsi Zhang, Jiao Chen, Ke Wang, Lu Liu, Jing Bao, Ming Chen, Xiaowei Qi, Mingxuan Gao   +10 more
wiley   +1 more source

Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG) [PDF]

, 2009
The human 3-methyladenine DNA glycosylase (AAG) recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine (Hx), and 1,N[superscript 6]-ethenoadenine (εA).
Aas P. A., Abner C. W., Adhikari S., Berti P. J., Bjelland S., Chakravarti D., Delaney J. C., Delaney J. C., Dianov G., Dosanjh M. K., Eftedal I., el Ghissassi F., Elder R. H., Engelward B. P., Falnes P. O., Falnes P. O., Falnes P. O., Frick L. E., Friedberg E. C., Gallagher P. E., Goodenough A. K., Guengerich F. P., Guengerich F. P., Guengerich F. P., Guliaev A. B., Hang B., Haushalter K. A., Hitchcock T. M., Koivisto P., Kusmierek J. T., Kusmierek J. T., Lau A. Y., Lau A. Y., Leonard N. J., Ludlum D. B., Miao F., Mishina Y., Nilsen H., Ougland R., O’Brien P. J., O’Brien P. J., O’Connor T. R., O’Connor T. R., O’Neill R. J., Pearl L. H., Pendlebury A., Ringvoll J., Roy R., Samson L., Saparbaev M., Saparbaev M., Saparbaev M., Singer B., Trewick S. C., Wang H., Westbye M. P., Wuenschell G. E., Wyatt M. D.   +57 more
core   +1 more source

Unscheduled DNA synthesis leads to elevated uracil residues at highly transcribed genomic loci in Saccharomyces cerevisiae.

PLoS Genetics, 2018
Recombination and mutagenesis are elevated by active transcription. The correlation between transcription and genome instability is largely explained by the topological and structural changes in DNA and the associated physical obstacles generated by the ...
Norah Owiti, Shanqiao Wei, Ashok S Bhagwat, Nayun Kim   +3 more
doaj   +1 more source

Suppression of Uracil-DNA Glycosylase Induces Neuronal Apoptosis [PDF]

Journal of Biological Chemistry, 2004
A chronic imbalance in DNA precursors, caused by one-carbon metabolism impairment, can result in a deficiency of DNA repair and increased DNA damage. Although indirect evidence suggests that DNA damage plays a role in neuronal apoptosis and in the pathogenesis of neurodegenerative disorders, the underlying mechanisms are poorly understood.
Yuri Kruman, Inna I. Kruman, Mark P. Mattson, Mark P. Mattson, Roy G. Cutler, Nigel H. Greig, Elena Schwartz, Xiaoxiang Zhu   +7 more
openaire   +3 more sources

Detection of uracil within DNA using a sensitive labeling method for in vitro and cellular applications [PDF]

, 2016
The role of uracil in genomic DNA has been recently re-evaluated. It is now widely accepted to be a physiologically important DNA element in diverse systems from specific phages to antibody maturation and Drosophila development.
Borsos, Máté, Békési, Angéla, Nagy, Kinga, Pálinkás, Hajnalka Laura, Róna, Gergely, Scheer, Ildikó, Tihanyi, Gergely, Vértessy, Beáta G.   +7 more
core   +1 more source

Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]

, 2020
Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu, Komor, Alexis C, Rallapalli, Kartik Lakshmi   +2 more
core   +2 more sources

The contribution of different uracil-DNA glycosylases to removal of uracil from DNA in different mouse organs - the significance of sequence context and proliferative status [PDF]

, 2014
Uracil is a non-canonical base in DNA that can arise through misincorporation of dUMP instead of dTMP during replication or from cytosine deamination.
Choudhury-Bhakta, Romi Roy
core