Results 81 to 90 of about 22,001 (241)

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases [PDF]

, 2012
Hydroxyl radicals predominantly react with the C(8) of purines forming 7,8-dihydro-8-oxoguanine (8oxoG) and 7,8-dihydro-8-oxoadenine (8oxoA) adducts, which are highly mutagenic in mammalian cells.
Couve, Sophie, Ishchenko, Alexander A., Kunz, Christophe, Saparbaev, Murat, Schär, Primo, Talhaoui, Ibtissam   +5 more
core   +2 more sources

The kinetics of uracil-N-glycosylase distribution inside replication foci

Scientific Reports
Mismatched nucleobase uracil is commonly repaired through the base excision repair initiated by DNA uracil glycosylases. The data presented in this study strongly indicate that the nuclear uracil-N-glycosylase activity and nuclear protein content in ...
Anna Ligasová, Ivo Frydrych, Barbora Piskláková, David Friedecký, Karel Koberna   +4 more
doaj   +1 more source

A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies

Exploration, Volume 5, Issue 2, April 2025.
The monkeypox virus (MPXV) has spread to many countries and caused thousands of infections all over the world. This review comprehensively introduces the biology, epidemiological characteristics of MPXV, and clinical manifestations of Mpox. The approaches for diagnosis, treatment, and prevention are also introduced, aiming to improve the general ...
Lin Jiang, Ailan Xu, Lin Guan, Yong Tang, Guangshuai Chai, Junya Feng, Yueqi Wu, Maochen Li, Chuxie Zhang, Xiaojing Liu, Xiaolong Xu, Qingquan Liu, Lihua Song, Yigang Tong, Renald Blundell, Huahao Fan   +15 more
wiley   +1 more source

Crystal structure and mutational analysis of human uracil-DNA glycosylase: Structural basis for specificity and catalysis [PDF]

, 1995
Crystal structures of the DNA repair enzyme human uracil-DNA glycosylase (UDG), combined with mutational analysis, reveal the structural basis for the specificity of the enzyme.
Alseth, Ingrun, Arvai, Andrew S, Kavli, Bodil, Krokan, Hans E, Mol, Clifford D, Slupphaug, Geir, Tainer, John A   +6 more
core   +1 more source

N6-methyladenosine in DNA promotes genome stability

eLife
DNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a ...
Brooke A Conti, Leo Novikov, Deyan Tong, Qing Xiang, Savon Vigil, Thomas J McLellan, Chuong Nguyen, Nancy De La Cruz, Reshma T Veettil, Prashant Pradhan, Parag Sahasrabudhe, Jason D Arroyo, Lei Shang, Benjamin R Sabari, David J Shields, Mariano Oppikofer   +15 more
doaj   +1 more source

Uracil DNA N-glycosylase promotes assembly of human centromere protein A. [PDF]

PLoS ONE, 2011
Uracil is removed from DNA by the conserved enzyme uracil DNA N-glycosylase (UNG). Previously, we observed that inhibiting UNG in Xenopus egg extracts blocked assembly of CENP-A, a histone H3 variant.
Samantha G Zeitlin, Brian R Chapados, Norman M Baker, Caroline Tai, Geir Slupphaug, Jean Y J Wang   +5 more
doaj   +1 more source

Life without dUTPase [PDF]

arXiv, 2015
Fine-tuned regulation of the cellular nucleotide pools is indispensable for faithful replication of DNA. The genetic information is also safeguarded by DNA damage recognition and repair processes. Uracil is one of the most frequently occurring erroneous base in DNA; it can arise from cytosine deamination or thymine-replacing incorporation.
arxiv  

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated‐B Cells

Exploration, EarlyView.
Bcas2 recruits DHX15 and SRSF7 to form a protein complex for the splicing of CSR‐related mRNA at the 5' ss and 3' ss, generating two mature mRNA isoforms, which are ultimately translated into CSR‐related proteins. These CSR‐related proteins bind to DNA associated with antibodies, affecting the DSB repair of the relevant DNA after AID induction, thereby
Yu Chen, Siyuan Sun, Chenxu Lu, Yixuan Li, Bing Fang, Xiangfeng Tang, Xuepeng Li, Weiru Yu, Yumei Lei, Longjie Sun, Ming Zhang, Jiazeng Sun, Ping Liu, Yongting Luo, Xingwang Zhao, Jing Zhan, Libing Liu, Rong Liu, Jiaqiang Huang, Ziwei Yi, Yifei Yu, Weihan Xiao, Zheng Ding, Lei Li, Dan Su, Fazheng Ren, Changchang Cao, Ran Wang, Wenbiao Shi, Juan Chen   +29 more
wiley   +1 more source

A THEORETICAL INVESTIGATION EXAMINING DNA CONFORMATIONAL CHANGES AND THEIR EFFECTS ON GLYCOSYLASE FUNCTION [PDF]

, 2011
Glycosylase enzymes initiate the process of base excision repair (BER) in order to prevent the irreversible modification of the genome. In the BER process a damaged DNA base is recognized, removed from the DNA sequence, and then the remaining abasic site
Brice, Allyn
core   +1 more source