Results 131 to 140 of about 165,169 (375)

Electron-induced hydrogen loss in uracil in a water cluster environment.

Journal of Chemical Physics, 2014
Low-energy electron-impact hydrogen loss due to dissociative electron attachment (DEA) to the uracil and thymine molecules in a water cluster environment is investigated theoretically.
M. Smyth, J. Kohanoff, I. Fabrikant, I. Fabrikant   +3 more
semanticscholar   +1 more source

Histochemical indications for a chemically complex signal produced by the cervical gill slit gland of the pygmy sperm whale (Kogia breviceps)

The Anatomical Record, EarlyView.
Abstract The pygmy sperm whale (Kogia breviceps) possesses an exocrine gland associated with its false gill slit pigmentation pattern. The cervical gill slit gland is a compound tubuloalveolar gland that produces a holocrine secretion and displays maturational changes in size and secretory histology. While the morphology of the cervical gill slit gland
Tiffany F. Keenan, William A. McLellan, Sentiel A. Rommel, Alexander M. Costidis, Craig A. Harms, J. G. M. Thewissen, Susan J. Rehorek, David S. Rotstein, Mark D. Gay, Alison R. Taylor, Heather N. Koopman, Ying Wang, Stephanie Kamel, D. Ann Pabst   +13 more
wiley   +1 more source

Fast, Efficient, and Versatile Synthesis of 6-amino-5-carboxamidouracils as Precursors for 8-Substituted Xanthines

Frontiers in Chemistry, 2019
Substituted xanthine derivatives are important bioactive molecules. Herein we report on a new, practical synthesis of 6-amino-5-carboxamidouracils, the main building blocks for the preparation of 8-substituted xanthines, by condensation of 5,6 ...
Daniel Marx, Lukas M. Wingen, Gregor Schnakenburg, Christa E. Müller, Matthias S. Scholz   +4 more
doaj   +1 more source

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation

European Journal of Immunology, 2014
Excision of uracil introduced into the immunoglobulin loci by AID is central to antibody diversification. While predominantly carried out by the UNG uracil‐DNA glycosylase as reflected by deficiency in immunoglobulin class switching in Ung−/− mice, the ...
Felix A. Dingler, K. Kemmerich, M. Neuberger, C. Rada   +3 more
semanticscholar   +1 more source

Implementation of mass pharmacogenetic testing: Dihydropyrimidine dehydrogenase testing prior to fluoropyrimidine treatment for patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Pharmacogenomics enables personalization of drug therapy improving effectiveness and/or safety. Dihydropyrimidine dehydrogenase [DPYD] testing prior to fluoropyrimidine chemotherapy was commissioned by NHS England in response to an update from the Medicines and Healthcare products Regulatory Agency.
Nisha Shaunak, Jessica Keen, Anna Kim, Munir Pirmohamed, William G. Newman, Paul J. Ross   +5 more
wiley   +1 more source

Synthesis of some novel annulated pyrido[2,3-d]pyrimidines via stereoselective intramolecular hetero Diels–Alder reactions of 1-oxa-1,3-butadienes

Beilstein Journal of Organic Chemistry, 2010
Some novel annulated pyrido[2,3-d]pyrimidines 6 and 7 were synthesized stereoselectively by intramolecular hetero Diels–Alder reactions involving 1-oxa-1,3-butadienes.
Mohit L. Deb, Pulak J. Bhuyan
doaj   +1 more source

Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer

BioEssays, EarlyView.
Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley   +1 more source

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, EarlyView.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

Exploring the Discrepancies in the Biological Activities of Extracts From Guadua angustifolia Var. Bicolor Londoño Collected in Two Different Sites

Chemistry &Biodiversity, EarlyView.
ABSTRACT Guadua angustifolia var. bicolor Lodoño is a Colombian bamboo species that has shown promising medicinal properties. This study aims to investigate the differences in the chemical composition and biological activity of extracts from two different populations of G. angustifolia var. bicolor, collected in Bauru and Tatuí, Brazil.
João Kazlauckas, Maria Tereza Grombone Guaratini, Paulo Roberto H. Moreno   +2 more
wiley   +1 more source

RESEARCHES ON PYRIMIDINES: SYNTHESIS OF URACIL-4-ACETIC ACID. [PDF]

, 1908
Henry L. Wheeler, Leonard M. Liddle
openalex   +1 more source