Results 111 to 120 of about 14,080 (252)
Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision
, 2019 Uracil DNA glycosylases (UDGs) are important DNA repair enzymes that excise uracil from DNA, yielding an abasic site. Recently, UdgX, an unconventional UDG with extremely tight binding to DNA containing uracil, was discovered.
Woo, Eui-Jeon +19 more
core +1 more source
Synthesis of Dinucleoside Analog of Uracil-Uracil [PDF]
Bulletin of the Chemical Society of Japan, 1973 Toru Seita +2 more
openaire +1 more source
A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells
Chemistry – A European Journal, EarlyView.A microbial metabolite covalently binds immunological protein MR1 to potently activate specific lymphocytes called MAIT cells, but it is too unstable for biological applications. Here, using synthesis, assays, protein crystallography, and computer modelling, we report a water‐stable analogue that activates reporter cells expressing the MAIT T cell ...
Jeffrey Y. W. Mak +9 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2010 Some novel annulated pyrido[2,3-d]pyrimidines 6 and 7 were synthesized stereoselectively by intramolecular hetero Diels–Alder reactions involving 1-oxa-1,3-butadienes.
Mohit L. Deb, Pulak J. Bhuyan
doaj +1 more source
Multivalent RNA‐Cleaving Agents on a Cubic Octameric Silsesquioxane Core
Chemistry – A European Journal, EarlyView.RNA‐cleaving agents on a cubic octameric silsesquioxane core were synthesized and characterized. Several catalytic systems of these structures were screened using hexaribonucleotide models. The best systems were then further used to study their catalytic efficiency in cleaving a HER2 mRNA model sequence. The induced cleavage sites were also determined.
Hanni Haapsaari, Iris Tuomi, Pasi Virta
wiley +1 more source
Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles
European Journal of Organic Chemistry, EarlyView.Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu +2 more
wiley +1 more source
, 1947 Uracil and the related compounds, thmine and cytosine occur in nature as components of nucleoproteins. Nucleoproteins are compounds of proteins with nucleic acids.
Grigg, Russell Mowbray
core +1 more source
International Journal of Cancer, EarlyView.What's New? This study introduces a novel approach for detecting locally advanced esophageal carcinoma using cell‐free DNA (cfDNA) analysis through a highly sensitive fragmentome assay. Unlike traditional sequencing‐based methods that are limited by the absence of specific mutations in esophageal tumors, our method offers an alternative by quantifying ...
Anouchka Modesto +21 more
wiley +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Adjuvant chemotherapy can improve outcomes for patients who have undergone lung cancer resection, and perioperative rehabilitation may help maintain the physical condition necessary to receive adjuvant chemotherapy. This observational cohort study investigated the impact of perioperative rehabilitation on the administration of postoperative ...
Shinkichi Takamori +12 more
wiley +1 more source
Solution photochemistry of thymine and uracil
, 1966 With dienes as specific triplet quenchers, it has been shown that the photodimerization of thymine in acetonitrile proceeds entirely through the triplet state and the photodimerization of uracil in acetonitrile or in water proceeds in part through the ...
Lamola, Angelo A., Mittal, Jai P.
core +1 more source