Results 201 to 210 of about 149,629 (313)

Crystal structure of a tRNA acceptor‐stem mimic at 1.94 Å resolution

Acta Crystallographica Section F, Volume 82, Issue 2, Page 57-65, February 2026.
This paper reports the structure solution of an RNA complex using anomalous scattering.Despite the theoretical advantages of phosphorus single‐wavelength anomalous diffraction (P‐SAD) for nucleic acid phasing, its application remains limited due to high atomic displacement parameters and an unfavourable ratio of unique reflections to anomalous ...
Ziwei Liu, Dom Bellini, Fabrice Gorrec, Armin Wagner, Kamel El Omari, John D. Sutherland   +5 more
wiley   +1 more source

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models. [PDF]

J Med Chem
Lizzadro L, Li J, Taha TY, Degotte G, Detomasi TC, Zapatero-Belinchon FJ, Hantz ER, Huang S, Matsui Y, Henderson WR, McCann JT, Montano M, Rosecrans J, Torres Pomares DF, McGovern BL, Diaz-Tapia R, Benjamin J, Gordon ME, Suazo ID, Settineri NS, Diallo A, Krogan NJ, Shoichet BK, Verba KA, Albrecht R, García-Sastre A, White KM, Ott M, Craik CS, Renslo AR.   +29 more
europepmc   +1 more source

Evaluation of the Role of the Vaccinia Virus Uracil DNA Glycosylase and A20 Proteins as Intrinsic Components of the DNA Polymerase Holoenzyme [PDF]

, 2011
Kathleen A. Boyle, Eleni S. Stanitsa, Matthew D. Greseth, Jill K. Lindgren, Paula Traktman   +4 more
openalex   +1 more source

Histone variants H3.3 and H2A.Z/H3.3 facilitate excision of uracil from nucleosome core particles

, 2022
Chuxuan Li, Katelyn L. Rioux, Sarah Delaney   +2 more
openalex   +2 more sources

Human FASTK preferentially binds single‐stranded and G‐rich RNA

The FEBS Journal, Volume 293, Issue 3, Page 729-748, February 2026.
Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak, Dawid A. Dzadz, Mikołaj I. Kuska, Madhuri Kanavalli, Maria M. Klimecka, Matthew Merski, Katarzyna J. Bandyra, Maria W. Górna   +7 more
wiley   +1 more source

Rapid access to the core of malayamycin A by intramolecular dipolar cycloaddition. [PDF]

Beilstein J Org Chem
Liu Y, Yang Y, Yang C, Huang SH, Jin J, Hong R.   +5 more
europepmc   +1 more source

The Molecular Configuration of Pyrimidines That Causes Allosteric Activation of Uracil Transport in Hymenolepis diminuta

, 1969
A. J. MacInnis, Robert K. Ridley
openalex   +1 more source

Biostimulants in plant brassinosteroid hormone receptor BRI1 activation—a new system to evaluate activation capacity

The FEBS Journal, Volume 293, Issue 3, Page 677-697, February 2026.
Biostimulants improve plant growth and have shown promise in agronomic applications and boosting crop yield. Because biostimulants typically present as a mixture of active components, new methods are required to characterize their mode of action. Here, we describe a novel assay that evaluates plant biostimulants targeting the brassinosteroid receptor ...
Maribel Marquina, Montserrat Ricart‐Fort, Rocío Díaz‐Parra, Sandra López‐Avilés, Tula Yance, Pablo Quirós, Elena Contreras, Ignasi Salaet, Sergio Atares, Rosa Aligué   +9 more
wiley   +1 more source

Design, synthesis, and biological evaluation of novel 6-(4-aminopiperidin-1-yl)-substituted benzyl-3-methylpyrimidine-2,4(1H,3H)-dione derivatives as potential anticancer agents targeting thymidylate synthase. [PDF]

Sci Rep
Baziar L, Ataollahi E, Rezaei Z, Abdulkadhim Y, Abdolahi MR, Poustforoosh A, Zare S, Emami M, Mansouri MM, Emami L, Khabnadideh S.   +10 more
europepmc   +1 more source

A Case of Severe Drug-Induced Hepatic Failure Caused by Continued Administration of Uracil/Tegafur (UFT) Capsules by Self-Judgement

, 2006
NORIAKI KITADA
openalex   +2 more sources