Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules
Molecules, 2019 Iodonium(III) salts bearing uracil moieties have recently appeared in the literature, but their structural scope and utilization are limited because of their hygroscopic characteristics.
Naoko Takenaga +6 more
doaj +1 more source
Frontiers in Immunology, 2021 Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed by uracil-DNA glycosylase ...
Marina Alexeeva +13 more
doaj +1 more source
Non-Empirically Tuned Range-Separated DFT Accurately Predicts Both Fundamental and Excitation Gaps in DNA and RNA Nucleobases [PDF]
, 2012 Using a non-empirically tuned range-separated DFT approach, we study both the quasiparticle properties (HOMO-LUMO fundamental gaps) and excitation energies of DNA and RNA nucleobases (adenine, thymine, cytosine, guanine, and uracil).
Foster, Michael E., Wong, Bryan M.
core +2 more sources
Thymine-Modified Nanocarrier for Doxorubicin Delivery in Glioblastoma Cells
Molecules, 2023 Brain tumor glioblastoma is one of the worst types of cancer. The blood–brain barrier prevents drugs from reaching brain cells and shields glioblastoma from treatment.
Albina Y. Ziganshina +10 more
doaj +1 more source
Synthesis of 5-substituted 2'-deoxyuridine-5'-phosphonate analogues and evaluation of their antiviral activity [PDF]
, 2012 A small series of 5-(hetero)aryl-modified nucleoside phosphonates was synthesized via an 8-step procedure including a Wittig reaction and Suzuki-Miyaura coupling.
Balzarini, Jan +4 more
core +1 more source
Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation
Frontiers in Immunology, 2019 Immunoglobulin (Ig) diversification occurs via somatic hypermutation (SHM) and class switch recombination (CSR), and is initiated by activation-induced deaminase (AID), which converts cytosine to uracil.
Ryan Costello +2 more
doaj +1 more source
Cell Lysis in S. pombe ura4 Mutants Is Suppressed by Loss of Functional Pub1, Which Regulates the Uracil Transporter Fur4. [PDF]
PLoS ONE, 2015 Schizosaccharomyces pombe Δura4 cells lyse when grown on YPD medium. A S. pombe non-essential gene deletion library was screened to determine suppressors of the lysis phenotype.
Kohei Nishino +4 more
doaj +1 more source
Prebiotic Route to Thymine from Formamide—A Combined Experimental–Theoretical Study
Molecules, 2021 Synthesis of RNA nucleobases from formamide is one of the recurring topics of prebiotic chemistry research. Earlier reports suggest that thymine, the substitute for uracil in DNA, may also be synthesized from formamide in the presence of catalysts ...
Lukáš Petera +12 more
doaj +1 more source
Density Functional Theory for the Photoionization Dynamics of Uracil
, 2007 Photoionization dynamics of the RNA base Uracil is studied in the framework of Density Functional Theory (DFT). The photoionization calculations take advantage of a newly developed parallel version of a multicentric approach to the calculation of the ...
Altmann S. L. +8 more
core +1 more source
Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo. [PDF]
, 2014 Spores of some species of the strictly anaerobic bacteria Clostridium naturally target and partially lyse the hypoxic cores of tumors, which tend to be refractory to conventional therapies. The anti-tumor effect can be augmented by engineering strains to
Dubois, L +10 more
core +4 more sources