Viruses with U-DNA: New Avenues for Biotechnology
Viruses, 2021 Deoxyuridine in DNA has recently been in the focus of research due to its intriguing roles in several physiological and pathophysiological situations. Although not an orthodox DNA base, uracil may appear in DNA via either cytosine deamination or thymine ...
Kinga K. Nagy +2 more
doaj +1 more source
The Escherichia coli RutR transcription factor binds at targets within genes as well as intergenic regions. [PDF]
, 2008 The Escherichia coli RutR protein is the master regulator of genes involved in pyrimidine catabolism. Here we have used chromatin immunoprecipitation in combination with DNA microarrays to measure the binding of RutR across the chromosome of ...
Akira Ishihama +24 more
core +5 more sources
The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance APOBEC3B (A3B) is overexpressed in multiple tumor types and a major source of mutation by converting DNA cytosines to uracils. A3B-positive tumors are often more heterogenous and result in poor clinical outcomes. We show that a proportion of
A. Serebrenik +8 more
semanticscholar +1 more source
A study of the valence photoelectron spectrum of uracil and mixed water–uracil clusters
The Journal of Chemical Physics, 2023 The valence ionization of uracil and mixed water–uracil clusters has been studied experimentally and by ab initio calculations. In both measurements, the spectrum onset shows a red shift with respect to the uracil molecule, with the mixed cluster characterized by peculiar features unexplained by the sum of independent contributions of the water or ...
Giuseppe Mattioli +15 more
openaire +7 more sources
Pyrimidine salvage in Toxoplasma gondii as a target for new treatment
Frontiers in Cellular and Infection Microbiology, 2023 Toxoplasmosis is a common protozoan infection that can have severe outcomes in the immunocompromised and during pregnancy, but treatment options are limited.
Hamza A. A. Elati +6 more
doaj +1 more source
Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase [PDF]
, 2013 Uracil-DNA glycosylase (UDG) compromises the replication strategies of diverse viruses from unrelated lineages. Virally encoded proteins therefore exist to limit, inhibit or target UDG activity for proteolysis.
A. R. Cole +39 more
core +1 more source
Analytical Chemistry, 2018 As one of the key initiators of the base excision repair process, uracil-DNA glycosylase (UDG) plays an important role in maintaining genomic integrity. It has been found that aberrant expression of UDG is associated with a variety of diseases.
Yichen Du +7 more
semanticscholar +1 more source
Synthesis of Some N1-Benzyl -6-(thio and alkyl or aryl thio) Uracil derivatives [PDF]
Kirkuk Journal of Science, 2013 New series of N1-Benzyl -6-(thio derivatives) Uracils have been prepared by reaction of 6-chloro uracil [F3] with benzyl chloride in dimethyl sulphoxide in presence of sodium carbonate to yield N1-Benzyl-6-chloro uracil [F4].Heating of [F4] in ethanol ...
Mohsin Omer Mohammad
doaj +1 more source
Low-energy electron collisions with gas-phase uracil [PDF]
, 2006 We have studied gas-phase collisions between slow electrons and uracil molecules with a view to understanding the resonance structure of the scattering cross section.
McKoy, Vincent, Winstead, Carl
core +1 more source
Road blocks on paleogenomes - polymerase extension profiling reveals the frequency of blocking lesions in ancient DNA [PDF]
, 2010 Although the last few years have seen great progress in DNA sequence retrieval from fossil specimens, some of the characteristics of ancient DNA remain poorly understood. This is particularly true for blocking lesions, i.e.
Briggs, A. +5 more
core +2 more sources