Results 161 to 170 of about 669,704 (210)

Potential signalling roles for utp and udp: sources, regulation and release of uracil nucleotides

Trends in Pharmacological Sciences, 1997
Increasing evidence for receptors for uracil nucleotides has focused interest on specific signalling mechanisms involving UTP and UDP. At least three metabotropic P2 receptors are stimulated by uracil nucleotides with equal or greater potency than by adenine nucleotides, and there might be ionotropic receptors as well.
Christopher Anderson
exaly   +6 more sources

Conversion of uracil nucleotides into isotopically labelled 5-substituted uracil nucleotides: a convenient route to thymine nucleotides

Journal of the Chemical Society Chemical Communications, 1984
Unprotected uracil nucleotides and nucleosides are converted into 5-formyluracil derivatives using a palladium(II) coupling reaction followed by oxidation of the intermediate styryl derivative.
J. Park, C. Bigge, Mohammed E. R. Hassan, L. Maggiora, M. Mertes   +4 more
exaly   +3 more sources

Effects of galactose on human leukocyte uracil nucleotides

International Journal of Biochemistry & Cell Biology, 1975
Abstract 1. 1. Uracil nucleotide contents of human leukocytes were determined by enzymatic analysis. The labelling pattern of uracil nucleotides was studied after incubation of the cells in the presence of [ 14 C]uridine followed by separation of the labelled nucleotides by paper chromatography. 2. 2. A depression of UTP, UDP, and UDP-glucose
Dietrich Keppler
exaly   +3 more sources

Stimulation of mouse cultured sympathetic neurons by uracil but not adenine nucleotides

Neuroscience, 2001
Cultured neurons from the paravertebral sympathetic chain of rats possess excitatory P2X as well as excitatory uracil nucleotide-sensitive P2Y receptors. Preliminary observations had indicated that the analogous neurons of mice lacked P2X receptors. This difference was now investigated.
Wolfgang Nörenberg
exaly   +5 more sources

Synthesis of 5-styryl derivatives of uracil nucleosides and nucleotides.

Tetrahedron Letters, 1979
Abstract Uracil nucleosides and nucleotides undergo a palladium catalyzed coupling reaction with styrenes to yield the respective 5-substituted derivatives.
Mathias P Mertes
exaly   +3 more sources

Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation.

Biochemical Pharmacology, 2008
Uracil nucleotides (i.e., UTP and UDP) have been known for years as fundamental intermediates in the de novo synthesis of the other pyrimidine nucleotides, which altogether represent key building blocks for nucleic acid synthesis. In addition, their sugar conjugates (i.e., UDP-glucose and UDP-galactose) enter in several biochemical routes, for example ...
D. Lecca, S. Ceruti
semanticscholar   +4 more sources

P2 receptors activated by uracil nucleotides--an update.

Current Medicinal Chemistry, 2006
Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling molecules which activate G protein-coupled membrane receptors (GPCRs) of the P2Y family. Four distinct pyrimidine nucleotide-sensitive P2Y receptor subtypes have been cloned, P2Y2, P2Y4, P2Y6 and P2Y14. P2Y2 and P2Y4 receptors are activated by UTP (the P2Y2, and the rat
A. Brunschweiger, C. Müller
semanticscholar   +3 more sources

Interaction of the retinal G-protein transducin with uracil nucleotides.

Biochemical and Biophysical Research Communications, 1999
Little is known about the interaction of pyrimidine nucleotides with G-proteins. Here we report that under experimental conditions that exclude transphosphorylation reactions, nucleoside 5'-triphosphates inhibited transducin-catalyzed GTP hydrolysis in the order of potency guanosine 5'-[gamma-thio]triphosphate > GTP > guanosine 5'-[beta,gamma-imido ...
J. F. Klinker, Roland Seifert
semanticscholar   +3 more sources

Cell Damage by Trapping of Biosynthetic Intermediates. The Role of Uracil Nucleotides in Experimental Hepatitis

Hoppe-Seyler's Zeitschrift Für Physiologische Chemie, 1971
Dietrich Keppler, Karl Decker, Wolfram Domschke   +2 more
exaly   +4 more sources

Palladium-catalyzed coupling reactions of uracil nucleosides and nucleotides

Journal of the American Chemical Society, 1980
Mathias P Mertes
exaly   +3 more sources