Results 141 to 150 of about 107,812 (233)

A novel and specific fluorescence reaction for uracil. [PDF]

Facile and specific methods to quantify a nucleobase in biological samples are of great importance for diagnosing disorders in nucleic acid metabolism. In the present study, a novel fluorogenic reaction specific for uracil has been developed.
Kai, Masaaki, Shibata, Takayuki, Kabashima, Tsutomu, Kawasaki, Shin-ya, Fujita, Jun-ya   +4 more
core  

Optimized TadA‐derived base editors efficiently manipulate mRNA splicing by A‐to‐G and C‐to‐K editing in potato

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3329-3339, September 2026.
Two optimized TadA‐derived base editors efficiently generate diverse splicing variants by targeting specific splice sites in potato. ABSTRACT Pre‐messenger RNA (pre‐mRNA) splicing is a critical mechanism for post‐transcriptional regulation in plants. Through alternative splicing, plants produce diverse transcriptomes and proteomes that finely regulate ...
Kaiyuan Chen, Yan Zhang, Jiuzhou Deng, Lumin Zhang, Huiying Zhou, Yaxin Duan, Enle Xiao, Guangtao Zhu, Chunzhi Zhang   +8 more
wiley   +1 more source

Cell‐Specific Expression and Cellular Compartmental Regulation in Camptothecin Biosynthesis

Plant Biotechnology Journal, Volume 24, Issue 9, Page 5114-5130, September 2026.
ABSTRACT Plant secondary metabolites such as monoterpenoid indole alkaloids (MIAs) show tightly regulated biosynthesis and accumulation in specific organelles of distinct cell types. However, the cell‐specific expression patterns of anticancer MIA camptothecin biosynthetic genes in Ophiorrhiza pumila and the regulatory mechanisms of camptothecin ...
Xiaolong Hao, Yinkai Yang, Tiantian Chen, Xiaoxuan Fan, Yiqing Peng, Qingyan Ruan, Qin Zhou, Fanghao Liu, Jiayi He, Yongpeng Li, Yue Feng, Jiyan Qi, Guoyin Kai   +12 more
wiley   +1 more source

Persistent Epigenetic Reprogramming Is Associated With Contrasting Drought‐Response Strategies in Citrus Scion–Rootstock Systems

Physiologia Plantarum, Volume 178, Issue 5, September/October 2026.
ABSTRACT Recurrent drought limits the productivity of perennial crops such as citrus, whose tolerance to water deficit largely depends on scion–rootstock interactions. Although physiological responses to recurrent drought are well documented, the epigenetic states associated with these responses remain poorly understood, limiting the use of epigenetic ...
Monique Ayala Araújo da Silva, Fredson dos Santos Menezes, Iris Sammarco, Lucas da Silva Costa, Claudia Fortes Ferreira, Soares Filho, Fabienne Micheli, Maurício Antônio Coelho‐Filho, Abelmon da Silva Gesteira   +8 more
wiley   +1 more source

Investigation of the role and mechanism of effect of nucleotides on the isolated hearts of molluscs

, 1968
1. All the four groujis of nucleotides investigated (adenine, guanine, uracil and cytosine) influence the functioning of the isolated Helix hearts. On Anodonta hearts cytosine nucleotides proved themselves to be ineffective.
Pécsi, Tibor, S.-Rózsa, Katalin
core   +1 more source

DNA–Peptide Crosslinks Placed at Codon 249 of the p53 Tumor Suppressor Gene Induce G to A Transitions in Human Cells

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
DNA‐peptide cross‐links (DpCs) are ubiquitous DNA lesions that form when cellular proteins become covalently trapped on DNA strands and are processed by proteases. DpCs are hypothesized to play a role in antitumor activity of chemotherapeutic drugs and to contribute to aging.
Priscilla Yawson, Jan Henric T. Bacurio, Honnaiah Vijay Kumar, Natalia Y. Tretyakova, Ashis K. Basu   +4 more
wiley   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence. [PDF]

Microbiologyopen
Joshi R, McEwan AG, Kappler U.
europepmc   +1 more source

Concordant RNA-protein evidence and human tissue metabolomics prioritize UPP1-associated nucleotide remodeling in prostate cancer. [PDF]

PLoS One
Chen X, Su W, Zhou Q, Qi Y, Xie J, Tang Y, Tang X, Fu H.   +7 more
europepmc   +1 more source

Pharmacological characterization of Uracil nucleotide-sensitive P2Y receptors in mouse ileum

, 2010
Since uracil nucleotide-preferring receptors, belonging to the P2Y receptor family and responding to either uridine triphosphate (UTP) or uridine diphosphate (UDP), have been proposed to be present at different cellular level in the gut, regulating ...
DI CRISTOFALO, AC, GRÄHLERT, J, ZIZZO, Maria Grazia, MULE', Flavia, SERIO, Rosa Maria   +4 more
core  

A Comprehensive Understanding of <i>DCTPP1</i> as an Emerging Therapeutic Target in Liver Cancer. [PDF]

Curr Issues Mol Biol
Ka HI, Jang SH, Kim HS, Jung HS, Eun JW.
europepmc   +1 more source