Results 131 to 140 of about 26,862 (228)

Contrasting effects of single stranded DNA binding protein on the activity of uracil DNA glycosylase from Escherichia coli towards different DNA substrates

, 1997
Excision of uracil from tetraloop hairpins and single stranded ('unstructured') oligodeoxyribonucleotides by Escherichia coli uracil DNA glycosylase has been investigated. We show that, compared with a single stranded reference substrate, uracil from the
Vinay Kumar, N., Varshney, U., Varshney, U, Kumar, N Vinay   +3 more
core   +1 more source

Urate‐Related Genetic Risk Modulates the Anti‐Aging Effects of Exogenous Nucleotides: Multi‐Omics Evidence From Older Adults

Aging Cell, Volume 25, Issue 6, June 2026.
In the TALENTs trial, 19‐week exogenous nucleotide supplementation produced UA‐PRS‐dependent anti‐aging responses: reduced DNA methylation age in High‐PRS individuals and preserved telomere length with improved immune–inflammatory profiles in Low‐PRS individuals, supporting precision nutrition for healthy aging.
Ruisheng Fu, Shuyue Wang, Yuxiao Wu, Xueying Qin, Tao Huang, Yong Li, Meihong Xu   +6 more
wiley   +1 more source

Mechanical stimulation-induced purinome priming fosters osteogenic differentiation and osteointegration of mesenchymal stem cells from the bone marrow of post-menopausal women

Stem Cell Research & Therapy
Background Mechanical stimulation (MS) significantly increases the release of adenine and uracil nucleotides from bone marrow-derived mesenchymal stem cells (BM-MSCs) undergoing osteogenic differentiation.
Catarina Bessa-Andrês, Rui Pinto-Cardoso, Karyna Tarasova, Ana Luísa Pereira-Gonçalves, Joana Maria Gaio-Ferreira-Castro, Liliana S. Carvalho, Maria Adelina Costa, Fátima Ferreirinha, Ana Canadas-Sousa, José Marinhas, Rolando Freitas, Rui Lemos, Adélio Vilaça, António Oliveira, Paulo Correia-de-Sá, José Bernardo Noronha-Matos   +15 more
doaj   +1 more source

Arbuscular Mycorrhiza Modulates Iron Distribution and Vacuolar Iron Transporter Expression in Tomato, Whereas Iron Limitation Reduces Mycorrhization

Plant, Cell &Environment, Volume 49, Issue 6, Page 3290-3305, June 2026.
ABSTRACT Plants have evolved highly efficient strategies to maintain iron (Fe) homeostasis. In this study, we investigate the impact of arbuscular mycorrhizal (AM) symbiosis on the Fe‐deficiency response and ionomic profile of tomato plants, as well as how Fe availability affects AM symbiosis.
Víctor M. López‐Lorca, Olga López‐Castillo, Mª Jesús Molina‐Luzón, Nuria Ferrol   +3 more
wiley   +1 more source

Advances in Visualizing Cytosine Methylation and Allele‐Specific Epigenetic States in Tissue Context

Pathology International, Volume 76, Issue 6, June 2026.
The ICON method enables sequence‐specific, bisulfite‐free visualization of DNA methylation through chemical recognition of methylated cytosines. Following probe hybridization under mild denaturing conditions, methylation‐dependent interstrand complexes are stabilized by covalent crosslinking.
Sohei Kitazawa, Ryuma Haraguchi, Riko Kitazawa   +2 more
wiley   +1 more source

Functional and structural insights into cyanobacterial CO2 concentrating mechanisms: from compartmentalization to regulation

The Plant Journal, Volume 126, Issue 5, June 2026.
Significance Statement Life on Earth depends on photosynthetic CO2 fixation via the Calvin–Benson–Bassham cycle to form organic carbon. This process evolved first in cyanobacteria and was later conveyed to eukaryotes, giving rise to plastids in algae and plants. To cope with low atmospheric CO2 concentrations that developed over the course of evolution,
Erik Zimmer, Carolin Poppitz, Stephan Klähn, Khaled A. Selim   +3 more
wiley   +1 more source

Organic Hazes as a Source of Life’s Building Blocks to Warm Little Ponds on the Hadean Earth

The Planetary Science Journal
Over 4 billion years ago, Earth is thought to have been a hazy world akin to Saturn’s moon Titan. The organic hazes in the atmosphere at this time could have contained a vast inventory of life’s building blocks and thus may have seeded warm little ponds ...
Ben K. D. Pearce, Sarah M. Hörst, Joshua A. Sebree, Chao He   +3 more
doaj   +1 more source

Characterization of Escherichia coli double-strand uracil-DNA glycosylase and analysis of uracil-initiated base excision DNA repair

Escherichia coli double-strand uracil-DNA glycosylase (Dug) was purified to apparent homogeneity from bacteria that were defective in uracil-DNA glycosylase (Ung). After cloning the dug gene, recombinant Dug was overexpressed, purified, and characterized
Sung, Jung-Suk
core  

SYNTHESIS, BIOLOGICAL PROPERTIES AND ANTI-HIV-1 ACTIVITY OF NEW PYRIMIDINE P1,P2-DINUCLEOTIDES [PDF]

, 2010
New homo- and hetero-P1,P2-dinucleotides were prepared with the use of multistep procedures starting from the monophosphates of 3'-fluoro-2-thiothymidine, 3'-fluoro-4-thiothymidine, AZT and 1-[(2-hydroxyethoxy)-methyl-5-propyl-6-phenylselenenyl]uracil ...
Miazga, Agnieszka, Lipniacki, Andrzej, Siwecka, Maria, Piasek, Andrzej, Ziemkowski, Przemysław, Kulikowski, Tadeusz   +5 more
core  

Raman scattering from adenine, uracil and their derivatives adsorbed at a silver electrode

, 1986
Adsorption at a silver electrode of adenine, uracil and their monomeric nucleosides and nucleotides from neutral solutions of KCl was studied by means of Raman spectroscopy and the measurement of the double-layer capacitance.
Katsumi Niki, Viktor Brabec
core   +1 more source