Results 131 to 140 of about 107,812 (233)

The Role of Metabolites in CSF on NAFLD Development: A Mendelian Randomisation Analysis

Endocrinology, Diabetes & Metabolism
Background Non‐alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition linked to metabolic syndrome. Recent studies suggest that metabolites in cerebrospinal fluid (CSF) may play a role in NAFLD development; however, the specific ...
Fang Liang, Tiegang Xiao, Bing Wang
doaj   +1 more source

Advances in large DNA fragment assembly for microbial cell factory engineering

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang, Wenqian Liu, Dongyuan Cheng, Jiazhang Lian, Xian Fu, Yue Shen   +5 more
wiley   +1 more source

Native Label‐Free Spectral Biochemical Fingerprinting of an Enveloped Mammalian RNA Virus Reveals Mode of Action of a Virucidal Drug

Small Methods, Volume 10, Issue 18, 23 September 2026.
Deep‐Ultraviolet Resonance Raman (DUVRR) spectroscopy is introduced as a label‐free, non‐invasive analytical workflow for the biochemical fingerprinting of enveloped viruses. By integrating bottom‐up stoichiometric reconstruction with top‐down biochemical extraction, this strategy accurately disentangles complex viral compositions in physiological‐like
Denis Rajnovic, Fatima Matroodi, Lamyaa M. Almehmadi, Tea Carletti, Alessandro Gessini, Igor K. Lednev, Claudio Masciovecchio, Alessandro Marcello, Barbara Rossi   +8 more
wiley   +1 more source

Expanding the Genetic Toolkit of Pichia kudriavzevii E1 for Enhanced Mycoprotein Production

Microbial Biotechnology, Volume 19, Issue 9, September 2026.
A library of endogenous promoters with a 455‐fold activity range was developed using an established episomal expression vector in the Pichia kudriavzevii E1 strain. The promoter library was used to regulate genes associated with nitrogen assimilation and pyruvate metabolism to enhance mycoprotein production.
Yupeng Wang, Shenghan Gao, Chenchen Wu, Liangchen Guo, Peijie Han, Limin Wang, Justyna Ruchała, Bo Yu   +7 more
wiley   +1 more source

Patterns of DNMT1 Promoter Methylation in Patients with Acute Lymphoblastic Leukemia

International Journal of Hematology-Oncology and Stem Cell Research, 2016
Background: Acute lymphoblastic leukemia (ALL) is a clonal malignant disorder characterized by an uncontrolled proliferation of immature T or B lymphocytes.
Tirdad Rahmani, Mehdi Azad, Bahram Chahardouli, Hajar Nasiri, Mousa Vatanmakanian, Saeid Kaviani   +5 more
doaj  

Novel Variants in PUS7 Associated With Intellectual Disability and Growth Retardation: Expanding the Clinical Spectrum in 13 Patients

Clinical Genetics, Volume 110, Issue 3, Page 379-388, September 2026.
Novel variants in PUS7 associated with intellectual disability and growth retardation: expanding the clinical spectrum in 13 patients. ABSTRACT Pseudouridylation is a frequent post‐transcriptional modification resulting in uridine isomerization in 5‐ribosyluracil, also called pseudouridine. This mechanism leads to RNA stability with an increase in base‐
Camille Bergès, Clément Sauvestre, Sophie Naudion, Catherine Vincent Delorme, Thomas Smol, Mélanie Rama, Stephanie Moortgat, Isabelle Maystadt, Rogier Kersseboom, Martina Wilke, Tahsin Stefan Barakat, Yoann Vial, Laurence Perrin, Sandrine Passemard, Farooq Ahmad, Muhammad Umair, Tobias Haack, Mona Grimmel, Alma Kuechler, Anne Slavotinek, Patrick Devine, Ugur Hodoglugil, Faisal Zafar, Erum Afzal, Tracy Dudding‐Byth, Guillaume Jouret, Lucas Herissant, Stephanie Efthymiou, Henry Houlden, Marine Legendre, Vincent Michaud   +30 more
wiley   +1 more source

URACIL-DNA GLYCOSYLASES PREFERENTIALLY EXCISE MISPAIRED URACIL

, 1992
We have investigated the substrate specificity of human, viral and bacterial uracil-DNA glycosylases employing as substrate double-stranded oligonucleotides containing in the same position of the 5'-P-32-labelled strand an uracil residue facing, on the ...
MAZZARELLO P, VERRI A, FOCHER F, SPADARI S   +3 more
core  

Homologous recombination mutants cause differing lethality between h− and h+ Schizosaccharomyces pombe strains due to mat1 heterochromatin

The FEBS Journal, Volume 293, Issue 17, Page 5205-5220, September 2026.
Homologous recombination (HR) in Schizosaccharomyces pombe is essential when mating‐type switching–induced double‐strand breaks (DSBs) form at the mat1 locus. In h90 and h− strains, efficient mat1 DSB formation renders HR indispensable unless suppressors block these breaks.
Peter Kolesar, Siarhei Paliavoi, Barbora Stefanovie, Jan Josef Palecek   +3 more
wiley   +1 more source

Coupling of both a transactivation module and a double‐stranded DNA‐binding domain boosts Cas12i3 variant‐based cytosine and adenine editing in plants

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3196-3207, September 2026.
Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang, Jingying Li, Yucai Li, Lei Yan, Christina Seok Yien Yong, Shaoya Li, Yubing He, Lanqin Xia   +7 more
wiley   +1 more source

Enhancing CRISPR‐Cas12a base editing in plants with LbCas12a variants and introns

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3243-3259, September 2026.
Intron optimization of LbCas12a‐RRV improves cytosine and adenine base editing efficiency in plants, supports multiplexed and double‐strand break‐free genome modification, and expands precise genome engineering tools for crop breeding and plant functional research. ABSTRACT Cytosine base editors (CBEs) and adenine base editors (ABEs) are powerful tools
Yanhao Cheng, Gen Li, Man Zhou, Rushil Mandlik, Doris Wang, Yiping Qi   +5 more
wiley   +1 more source