Results 111 to 120 of about 26,862 (228)

Tiling Nussinov’s RNA folding loop nest with a space-time approach

BMC Bioinformatics, 2019
Background An RNA primary structure, or sequence, is a single strand considered as a chain of nucleotides from the alphabet AUGC (adenine, uracil, guanine, cytosine).
Marek Palkowski, Wlodzimierz Bielecki
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, Volume 16, Issue 6, Page 1087-1101, June 2026.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Degradation of Pyrimidines in Saccharomyces Kluyveri: Transamination of beta-Alanine.

, 2008
Beta-alanine is an intermediate in the reductive degradation of uracil. Recently we have identified and characterized the Saccharomyces kluyveri PYD4 gene and the corresponding enzyme beta -alanine aminotransferase ((Sk)Pyd4p), highly homologous to ...
Schnackerz, KD, Andersen, Gorm, Piskur, Jure, Schnackerz, K D, Andersen, Gorm,, Dobritzsch, D, Andersen, G, Lund University., Dobritzsch, D,, Piskur, J, Dobritzsch, Doreen,   +10 more
core   +1 more source

A proton magnetic resonance investigation of the glycosyl torsion angle of uracil nucleosides and nucleotides

Nucleic Acids Research, 1975
The use of line-shape decomposition techniques permitted the small 5-bond (5-J51') and 4-bond (4-J61') proton-proton coupling constants of a series of uracil nucleosides and nucleotides to be determined accurately. From an analysis of these coupling constants we have determined that the uracil base is in a predominantly anti conformation in aqueous ...
T, Schleich, T R, Lusebrink, B P, Cross, N P, Johnson   +3 more
openaire   +3 more sources

Exploring the Potential of Zero‐Dimensional Carbon Nanomaterials in Photoluminescent, Electrochemiluminescent and Electrochemical Sensors

Advanced Materials Interfaces, Volume 13, Issue 11, 9 June 2026.
Zero‐dimensional carbon nanomaterials are presented as multifunctional platforms linking structure, property, and sensing performance. Surface engineering and heteroatom doping modulate electron‐transfer and luminescent behavior, enabling electrochemical, photoluminescent, and electrochemiluminescent detection. Fundamental design principles, analytical
Gustavo Martins, Jeferson Luiz Gogola, Ava Gevaerd, Cristiane Kalinke, Paulo Roberto de Oliveira, Fabio Roberto Caetano, Bruno Campos Janegitz, Márcio Fernando Bergamini, Luiz Humberto Marcolino‐Junior   +8 more
wiley   +1 more source

Repair and DNA Polymerase Bypass of Clickable Pyrimidine Nucleotides

Biomolecules
Clickable nucleosides, most often 5-ethynyl-2′-deoxyuridine (EtU), are widely used in studies of DNA replication in living cells and in DNA functionalization for bionanotechology applications.
Anton V. Endutkin, Anna V. Yudkina, Timofey D. Zharkov, Alexander E. Barmatov, Daria V. Petrova, Daria V. Kim, Dmitry O. Zharkov   +6 more
doaj   +1 more source

Catalytic mechanism of alpha-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling.

, 2013
Enzymatic synthesis and hydrolysis of nucleoside phosphate compounds play a key role in various biological pathways, like signal transduction, DNA synthesis and metabolism.
Bodor, A., Vértessy, Beáta G, Kele, Z., Wilmanns, Matthias, Perczel, András, Perczel, A., Vértessy, Beáta G., Rosta, Edina, Zagyva, Imre, Grolmusz, Vince I., Barabás, Orsolya, Németh, Veronika, Vertessy, B. G., Grolmusz, Vince I, Barabas, O., Grolmusz, V. I., Vértessy G., Beáta, Kele, Zoltán, Szabadka, Zoltán, Zagyva, I., Wilmanns, M., Szabadka, Z., Rosta, E., Nemeth, V., Bodor, Andrea   +24 more
core   +1 more source

Electroacupuncture Ameliorates Cognitive Impairment in Vascular Dementia Rats: Potential Involvement of the Astrocyte–Synapse Axis

Brain and Behavior, Volume 16, Issue 6, June 2026.
Electroacupuncture significantly ameliorates cognitive impairment and synaptic damage in vascular dementia rats, showing specific advantages over nimodipine. These neuroprotective effects are closely associated with modulating the astrocyte–synapse axis to suppress neuroinflammation and enhance neurotrophic support.
Sijing Guo, Qian Liu, Shihao Lin, Taotao Zhou, Qin Hu, Zhongsheng Tang   +5 more
wiley   +1 more source

Functionalizing Nucleobases With Boronic Acids and Boronic Acid Esters: Thymine Derivatives and Their Dioxazaborocane Chemistry

ChemPlusChem, Volume 91, Issue 6, June 2026.
Boronic acid‐substituted thymine derivatives are well established and exhibit a range of biological activities. In contrast, the corresponding boronic acid esters and dioxazaborocane analogs remain largely unexplored. Herein, we report the synthesis and structural characterization of thymine derivatives bearing boronic acid, boronic acid ester, and ...
Tabea Lenz, Marcus Layh, Marian Hebenbrock   +2 more
wiley   +1 more source

Neq2X7: a multi-purpose and open-source fusion DNA polymerase for advanced DNA engineering and diagnostics PCR

BMC Biotechnology
Thermostable DNA polymerases, such as Taq isolated from the thermophilic bacterium Thermus aquaticus, enable one-pot exponential DNA amplification known as polymerase chain reaction (PCR). However, properties other than thermostability - such as fidelity,
Cristina Hernández-Rollán, Anja K. Ehrmann, Arsenios Vlassis, Vijayalakshmi Kandasamy, Morten H. H. Nørholm   +4 more
doaj   +1 more source