Results 111 to 120 of about 49,133 (225)
Visualizing and Quantifying microRNA‐Induced DNA Origami Separation at the Nanoscale
Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.Clinically relevant miRNA biomarkers trigger the disassembly of DNA origami dimers into monomers through a toehold‐mediated strand displacement reaction. High‐speed AFM was used to visualize this reaction in real time, while solid‐state nanopore measurements quantified the populations of dimers and monomers, as well as the resulting miRNA concentration,
Chalmers C. C. Chau +4 more
wiley +2 more sources
Molecular Therapy: Nucleic Acids, 2014 Limited chemical diversity of nucleic acid libraries has long been suspected to be a major constraining factor in the overall success of SELEX (Systematic Evolution of Ligands by EXponential enrichment).
John C Rohloff +6 more
doaj +1 more source
Brain and Behavior, Volume 16, Issue 5, May 2026.Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah +7 more
wiley +1 more source
CRISPR Genome Editing and the Future of Leukaemia Immunotherapy
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aims Leukaemia presents ongoing therapeutic challenges due to relapse and toxicity associated with standard treatments. By enabling more targeted and safer therapies, CRISPR genome editing is emerging as a powerful tool to address these issues.
Dejin Rai, Umberto Terranova
wiley +1 more source
Frontiers in Microbiology, 2018 Comparative genome analyses have led to the discovery and characterization of novel flavin- and folate-dependent methyltransferases that mainly function in DNA precursor synthesis and post-transcriptional RNA modification by forming (ribo) thymidylate ...
Hannu Myllykallio +4 more
doaj +1 more source
Concurrent Oxidative and Reductive Protometabolic Reactions Driven by Electrochemistry
ChemSystemsChem, Volume 8, Issue 3, May 2026.Electrochemistry offers a possible solution to a key question in prebiotic chemistry: how oxidative and reductive reactions could occur simultaneously as they do in modern biochemistry. This study shows that essential redox reactions from the reverse tricarboxylic acid (rTCA) cycle and nucleotide synthesis can be driven concurrently by electrochemistry,
Clara Vega +5 more
wiley +1 more source
Tiling Nussinov’s RNA folding loop nest with a space-time approach
BMC Bioinformatics, 2019 Background An RNA primary structure, or sequence, is a single strand considered as a chain of nucleotides from the alphabet AUGC (adenine, uracil, guanine, cytosine).
Marek Palkowski, Wlodzimierz Bielecki
doaj +1 more source
Plant Biotechnology Journal, Volume 24, Issue 5, Page 2956-2969, May 2026.ABSTRACT Base excision repair (BER) is a critical pathway for repairing damaged DNA bases in cells; however, the mechanisms of protein recruitment and interaction in this pathway remain largely unexplored in higher plants. In this study, we used ‘84K’ poplar (Populus alba × P.
Aoyu Ling +8 more
wiley +1 more source
Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK). [PDF]
, 1979 Madin-Darby canine kidney (MDCK) cells grown in tissue culture have the morphological properties of distal tubular epithelial cells, form tight junctions, and lack several proximal tubular enzyme markers.
Chuman, LM +3 more
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