Results 101 to 110 of about 26,862 (228)
Advances in large DNA fragment assembly for microbial cell factory engineering
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang +5 more
wiley +1 more source
Analysis &Sensing, Volume 6, Issue 4, July 2026.This study presents a multimatrix untargeted metabolomics analysis of fecal, plasma, and urine samples from individuals at high risk for pancreatic cancer development. Integrated multivariate and cofactor‐adjusted models were applied to characterize cross‐matrix metabolomic associations, incorporating pancreatic magnetic resonance imaging data, sex ...
Vladyslav Dovhalyuk +6 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2014 Limited chemical diversity of nucleic acid libraries has long been suspected to be a major constraining factor in the overall success of SELEX (Systematic Evolution of Ligands by EXponential enrichment).
John C Rohloff +6 more
doaj +1 more source
, 2016 We previously designed 1-(3-C-ethynyl-β-d-ribo-pentofuranosyl)uracil (EUrd) and its cytosine congener (ECyd) as potential multifunctional antitumor nucleoside antimetabolites. They showed potent and broad-spectrum antitumor activity against various human
Tomoharu Iino (3022167) +10 more
core +1 more source
Pyruvate Kinase M2 Mediates Apigenin‐Induced Energy Crisis and Apoptosis in Colon Cancer Cells
Food Frontiers, Volume 7, Issue 4, July 2026.Apigenin, a dietary flavonoid with low toxicity, induces profound bioenergetic collapse in colon cancer cells by downregulating PKM2. This metabolic crisis, characterized by suppressed glycolysis and mitochondrial dysfunction, ultimately triggers robust apoptosis.
Ke Zhang +3 more
wiley +1 more source
, 2014 International audienceWe characterized two additional membrane transporters (Fur4p and Dal4p) of the nucleobase cation symporter 1 (NCS1) family involved in the uptake transport of pyrimidines and related molecules in the opportunistic pathogenic yeast ...
Accoceberry, Isabelle +8 more
core +2 more sources
ChemSystemsChem, Volume 8, Issue 4, July 2026.Oligonucleotides form spontaneously through hot wet‐dry cycling of pure non‐activated nucleotides. No catalytic agents were added, and pH was naturally buffered by the nucleotides. Oligonucleotide formation was confirmed and quantified using mass spectrometry, spectroscopy and electrophoresis, establishing a solid baseline for the intrinsic extent of ...
Simon H. J. Eiby +5 more
wiley +1 more source
Frontiers in Microbiology, 2018 Comparative genome analyses have led to the discovery and characterization of novel flavin- and folate-dependent methyltransferases that mainly function in DNA precursor synthesis and post-transcriptional RNA modification by forming (ribo) thymidylate ...
Hannu Myllykallio +4 more
doaj +1 more source
, 2017 Conformationally locked uridine in the 'southern' conformation, which could be an important precursor for corresponding nucleotides, was stereoselectively synthesized.
류재상
core +1 more source
Environmental Toxicology, Volume 41, Issue 7, Page 379-394, July 2026.ABSTRACT Plastic, with its remarkable versatility and numerous applications, has greatly benefited humanity. However, its extreme resistance to natural degradation means it persists in the environment for long periods, causing global environmental problems.
Teresa Chianese +13 more
wiley +1 more source