Results 141 to 150 of about 2,667 (184)

Exopolysaccharides from <i>Lactiplantibacillus plantarum</i> WLPL04 Alleviate Hyperuricemia by Regulating Uric Acid Metabolism and Gut Microbiota. [PDF]

Foods
Wei M, Hu Y, Li X, Long X, Zhang Z, Tao X, Wei H.   +6 more
europepmc   +1 more source

Empagliflozin improves renal injury of diabetic nephropathy complicated with hyperuricemia through AMPK by promoting autophagy and inhibiting apoptosis. [PDF]

Saudi Pharm J
Zhang Z, Xu Y, Xu C, Gao Q, Wu X, Wu T.
europepmc   +1 more source

Polyphenol-Rich Extract from <i>Archidendron clypearia</i>: Optimization, Characterization, and Hypouricemic Activity. [PDF]

Molecules
Yan D, Hong Z, Zhao Z, Yang W, Yang D.
europepmc   +1 more source

Editorial: Regulation and mechanism of plant metabolites on hyperuricemia. [PDF]

Front Nutr
Wan Y, Qian J, Xiong T, Lu J.
europepmc   +1 more source

From Multidimensional Management to Mechanistic Insight: A Review of Interventions for Hyperuricemia. [PDF]

Int J Mol Sci
Sun Q, Yin L.
europepmc   +1 more source

Systematic Structure-Activity Relationship (SAR) Exploration of Diarylmethane Backbone and Discovery of a Highly Potent Novel Uric Acid Transporter 1 (URAT1) Inhibitor

Molecules, 2018
In order to systematically explore and better understand the structure-activity relationship (SAR) of a diarylmethane backbone in the design of potent uric acid transporter 1 (URAT1) inhibitors, 33 compounds (1a–1x and 1ha–1hi) were designed and ...
Guilong Zhao, Jingwei Wu, Lida Tang
exaly   +2 more sources

Structural Basis for Inhibition of Urate Reabsorption in URAT1

Jacs Au
The urate transporter 1 (URAT1) is the primary urate transporter in the kidney responsible for urate reabsorption and, therefore, is crucial for urate homeostasis. Hyperuricemia causes the common human disease gout and other pathological consequences. Inhibition of urate reabsorption through URAT1 has been shown as a promising strategy in alleviating ...
Xiaoguang Lei, Junping Fan, Nianxin Guo
exaly   +4 more sources

Virtual Screening and Biological Evaluation of Natural Products as Urate Transporter 1 (URAT1) Inhibitors

Journal of Biomolecular Structure and Dynamics
Hyperuricemia is mainly caused by insufficient renal urate excretion. Urate transporter 1 (URAT1), an organic anion transporter, is the main protein responsible for urate reabsorption.
Fengli Yao, Yidan Zhang
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Interactions of Urate Transporter URAT1 in Human Kidney With Uricosuric Drugs

Nephrology, 2011
ABSTRACTAim: Hyperuricaemia is a significant factor in a variety of diseases, including gout and cardiovascular diseases. The kidney plays a dominant role in maintaining plasma urate levels through the excretion process. Human renal urate transporter URAT1 is thought to be an essential molecule that mediates the reabsorption of urate on the apical side
Atsushi Enomoto, Naohiko Anzai, Hiroki Miyazaki   +2 more
exaly   +3 more sources

Functional Cooperation of SMCTs and URAT1 for Renal Reabsorption Transport of Urate

Drug Metabolism and Pharmacokinetics, 2013
  Urate is mainly excreted into urine in humans. Serum urate level is regulated by a urate transport system located on the renal proximal tubule. Urate transporter 1 (URAT1) is located on the apical side of the renal proximal tubule and is responsible for the reabsorption of urate from the luminal side into tubular cells.
Takeo Nakanishi, Yang Lu, Ikumi Tamai
exaly   +3 more sources