Structure-Based Virtual Screening of Plant-Derived Flavonoids as Putative GLUT9 Binders with Antioxidant Properties [PDF]
MoleculesHyperuricemia affects approximately 20% of the global adult population and serves as the primary etiological factor for gout. Glucose transporter 9 (GLUT9) plays a critical role in renal urate reabsorption, representing a promising therapeutic target for
Kevser Kübra Kırboğa +3 more
doaj +2 more sources
Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System
Cells, 2022 Background: Hyperuricemia is a common laboratory finding in pregnant women compromised by preeclampsia. A growing body of evidence suggests that uric acid is involved in the pathogenesis of preeclampsia.
Marc Baumann +2 more
exaly +3 more sources
Interaction Between ITM2B and GLUT9 Links Urate Transport to Neurodegenerative Disorders
Frontiers in Physiology, 2019 Hyperuricemia plays a critical causative role in gout. In contrast, hyperuricemia has a protective effect in neurodegenerative disorders, including Alzheimer’s Disease.
David Bruce Mount, Asim K Mandal
exaly +3 more sources
Molecular interplay between TXNIP and GLUT9 underlies uric acid transport dysregulation in vitro under hyperuricemic stress [PDF]
European Journal of Medical ResearchBackground This study aimed to investigate the role of Thioredoxin Interacting Protein (TXNIP) in hyperuricemia, specifically examining its influence on uric acid (UA) metabolism and the associated processes.
Yuqiu Zhu +8 more
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Advances in post-translational and epigenetic modification of hyperuricemia-to-gout progression: mechanisms and therapeutic targets [PDF]
Frontiers in Cell and Developmental BiologyHyperuricemia (HUA) and gout are endocrine disorders resulting from abnormal uric acid (UA) metabolism, with gout typically developing secondary to HUA and being associated with an exacerbated inflammatory response.
Wei Fu +9 more
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A Novel Dual URAT1/GLUT9 Inhibitor Reduces Hyperuricemia by Enhancing Uric Acid Excretion and Attenuating Renal Fibrosis [PDF]
PharmaceuticalsBackground: Hyperuricemia (HUA) is a metabolic disorder that severely threatens human health. Chronic uric acid (UA) overload promotes the progression of tubulointerstitial fibrosis (TIF), leading to impaired UA excretion. Our previous studies identified
Hailong Zhang +6 more
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Comparative study of the glucolipid profile and GLUTs gene expression in response to insulin treatment across three chicken breeds [PDF]
Poultry ScienceGiven selective breeding has resulted in pronounced differences in muscle development and production traits among broilers, layers, and silkies, this study systematically compared breed-specific variations in growth performance, serum biochemical markers,
Z.Y. Wang +9 more
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Chicken serum uric acid level is regulated by glucose transporter 9 [PDF]
Animal Bioscience, 2021 Objective Glucose transporter 9 (GLUT9) is a uric acid transporter that is associated with uric absorption in mice and humans; but it is unknown whether GLUT9 involves in chicken uric acid regulation.
Xuedong Ding +9 more
doaj +1 more source
Urate transporters: Structural mechanisms and therapeutic opportunities in drug development [PDF]
Acta Pharmaceutica Sinica BQian Yang +5 more
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Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study. [PDF]
PLoS ONE, 2008 BACKGROUND: Serum uric acid (UA) levels have recently been shown to be genetically influenced by common polymorphisms in the GLUT9 gene in two genome-wide association analyses of Italian and British populations.
Klaus Stark +11 more
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