Function of Uric Acid Transporters and Their Inhibitors in Hyperuricaemia [PDF]
Frontiers in Pharmacology, 2021 Disorders of uric acid metabolism may be associated with pathological processes in many diseases, including diabetes mellitus, cardiovascular disease, and kidney disease. These diseases can further promote uric acid accumulation in the body, leading to a
Hao-lu Sun +6 more
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Uric acid transporters BCRP and MRP4 involved in chickens uric acid excretion [PDF]
BMC Veterinary Research, 2019 Background Breast cancer resistance protein (BCRP) and multidrug resistance protein 4 (MRP4) are involved in uric acid excretion in humans and mice.
Xuedong Ding +11 more
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Mammary gland, kidney and rumen urea and uric acid transporters of dairy cows differing in milk urea concentration [PDF]
Scientific Reports, 2023 The milk urea concentration (MUC) serves as indicator of urinary nitrogen emissions, but at comparable crude protein (CP) intake, cows with high (HMU) and low (LMU) MUC excrete equal urea amounts.
Marie C. Prahl +3 more
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Exercise serum regulates uric acid transporters in normal rat kidney cells [PDF]
Scientific Reports, 2022 Hyperuricemia (HUA) refers to a physiological condition of high serum uric acid (SUA) level in the body, which may cause an increased risk of several chronic diseases. The kidney’s impaired uric acid (UA) metabolism is an important reason for HUA.
Zhongye Jiang +6 more
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Concentration-Dependent Inhibitory Effect of Irbesartan on Renal Uric Acid Transporters
Journal of Pharmacological Sciences, 2010 Hyperuricemia is currently recognized as a risk factor for cardiovascular diseases. It has been reported that the angiotensin II–receptor blocker (ARB) losartan decreases serum uric acid level.
Makiko Nakamura +5 more
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The roles of gut microbiota and their metabolites in uric acid–related metabolic diseases: mechanisms and therapeutic targets [PDF]
Frontiers in MicrobiologyGut microbiota and their metabolites play a central regulatory role in uric-acid–related metabolic diseases, serving as a crucial interface linking purine metabolism with host inflammatory responses.
Haochen Li +4 more
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Progress on the role of ABCG2 and SLC2A9 in the onset of hyperuricemia and gout [PDF]
Jichu yixue yu linchuang, 2023 ABCG2 and SLC2A9 encode the uric acid transporters ABCG2 and GLUT9. ABCG2 single nucleotide polymorphism (SNP) can reduce the expression and transport function of ABCG2 protein, and then cause intestinal uric acid excretion dysfunction, resulting in the ...
YANG Lijuan, DONG Qiumei, WU Hao
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Research progress on pathophysiology, diagnosis and treatment of uric acid stones [PDF]
Yixue xinzhi zazhi, 2022 Uric acid stones are a common type of stone in the urinary system being the only stone that can be dissolved by drugs. The incidence of uric acid stone is increasing worldwide. It is very important to have an in depth understanding of the pathogenesis of
ZHANG Kaineng, KE Changxing
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Advances in Urate Excretion and Urate Transporters in Hyperuricemia [PDF]
Zhongguo quanke yixue, 2023 Hyperuricemia is a heterogeneous disease caused by dysregulation of the homeostasis of urate production and excretion, which leads to the elevation of blood uric acid beyond the normal range.
XIN Jiadong, ZHOU Jiabao, WU Zhiyuan, ZHANG Xuming, GAO Jiandong
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The Role of the Intestine in the Development of Hyperuricemia
Frontiers in Immunology, 2022 Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints. Hyperuricemia is the fundamental factor of gout.
Hui Yin +5 more
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