Renal Transport of Uric Acid: Evolving Concepts and Uncertainties [PDF]
Advances in Chronic Kidney Disease, 2012 In addition to its role as a metabolic waste product, uric acid has been proposed to be an important molecule with multiple functions in human physiologic and pathophysiologic processes and may be linked to human diseases beyond nephrolithiasis and gout.
Ion Alexandru, Bobulescu, Orson W, Moe
openaire +2 more sources
Genistein ameliorates hyperuricemia-associated nephropathy in hyperuricemic mice
Food and Agricultural Immunology, 2021 Hyperuricemia is a metabolic disease caused by excessive production of uric acid (UA), which can cause gout, hypertension, hyperlipidemia and other diseases.
Bi Wei-Yun, Zhu Cailin
doaj +1 more source
Uric acid is more strongly associated with impaired glucose regulation in women than in men from the general population: the KORA F4-Study. [PDF]
, 2012 High serum uric acid (UA) levels are associated with the metabolic syndrome, type 2 diabetes and cardiovascular disease. It is largely unknown whether there are gender-specific differences regarding the association between UA and prediabetic states.
Döring, Angela +23 more
core +2 more sources
Molecular Mechanism of Ethanol Extract from Hippocampus abdominalis in Improving Hyperuricemia in Mice [PDF]
Shipin KexueObjective: To study the effect and molecular mechanism of ethanol extract from Hippocampus abdominalis on hyperuricemia in mice. Methods: The chemical components in the ethanol extract and the mouse serum were analyzed using high performance chemical ...
ZHANG Jiayuan, FENG Biyun, LI Lingyan, YANG Xinhui, KONG Yaling, WANG Suping, LI Ming, XU Guanghui
doaj +1 more source
A model of uric acid transport in the rat proximal tubule [PDF]
American Journal of Physiology-Renal Physiology, 2019 The objective of the present study was to theoretically investigate the mechanisms underlying uric acid transport in the proximal tubule (PT) of rat kidneys, and their modulation by factors, including Na + , parathyroid hormone, ANG II, and Na ...
Edwards, A. +3 more
openaire +4 more sources
Phytochemical, Pharmacological And Pharmacokinetic Studies Of Phyllanthus Niruri Linn Lignans As Potential Antihyperuricemic Agents [QK861. V694 2008 f rb]. [PDF]
, 2008 Ekstrak metanol dari daun Phyllanthus niruri L. menunjukkan aktiviti antihiperurisemik oral yang bergantungan dos di dalam tikus hiperurisemia yang diaruh dengan kalium oksonat dan asid urik. The methanol extract from the leaves of Phyllanthus niruri
Murugaiyah, Vikneswaran
core +1 more source
Biomolecules, 2023 The prevalence of patients with hyperuricemia or gout is increasing worldwide. Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors like consuming a purine-rich diet, alcohol and/or fructose intake, and ...
Masanari Kuwabara +20 more
doaj +1 more source
Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]
, 2008 <p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Lees, K.R. +6 more
core +1 more source
Loss of the Kidney Urate Transporter, Urat1, Leads to Disrupted Redox Homeostasis in Mice
Antioxidants, 2023 High uric acid is associated with gout, hypertension, metabolic syndrome, cardiovascular disease, and kidney disease. URAT1 (SLC22A12), originally discovered in mice as Rst, is generally considered a very selective uric acid transporter compared to other
Neema Jamshidi +2 more
doaj +1 more source
FEBS Open Bio, 2018 Here, we report that a novel nucleobase cation symporter 2 encoded in the genome of the honeybee bacterial pathogen Paenibacillus larvae reveals high levels of amino acid sequence similarity to the Escherichia coli and Bacillus subtilis uric acid and ...
Amanda J. Stoffer‐Bittner +4 more
doaj +1 more source