Results 11 to 20 of about 2,782,099 (278)
Uric acid transporter inhibitors for gout [PDF]
ADMET and DMPK, 2017 Gout is a common inflammatory arthritis that is caused by chronically-elevated serum uric acid (sUA) levels (hyperuricemia). In humans, sUA levels are predominantly controlled by a variety of transporters that mediate the elimination of uric acid through
Philip K. Tan, Jeffrey N. Miner
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Asian Journal of Pharmaceutical Sciences, 2020 Uric acid is the end product of purine catabolism and its plasma levels are maintained below its maximum solubility in water (6–7 mg/dl). The plasma levels are tightly regulated as the balance between the rate of production and the rate of excretion, the
Bojana Ristic +3 more
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Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells. [PDF]
PLoS ONEUric acid induces radical oxygen species formation, endothelial inflammation, and endothelial dysfunction which contributes to the progression of atherosclerosis.
Karel H van der Pol +13 more
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Recent advances on uric acid transporters. [PDF]
Oncotarget, 2017 Uric acid is the product of purine metabolism and its increased levels result in hyperuricemia. A number of epidemiological reports link hyperuricemia with multiple disorders, such as kidney diseases, cardiovascular diseases and diabetes. Recent studies also showed that expression and functional changes of urate transporters are associated with ...
Xu L, Shi Y, Zhuang S, Liu N.
europepmc +4 more sources
The systems biology of uric acid transporters: the role of remote sensing and signaling. [PDF]
Curr Opin Nephrol Hypertens, 2018 Uric acid homeostasis in the body is mediated by a number of SLC and ABC transporters in the kidney and intestine, including several multispecific 'drug' transporters (e.g., OAT1, OAT3, and ABCG2). Optimization of uric acid levels can be viewed as a 'systems biology' problem.
Nigam SK, Bhatnagar V.
europepmc +4 more sources
Uric acid transport and disease [PDF]
Journal of Clinical Investigation, 2010 Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant properties that may be protective but can also be pro-oxidant, depending on its chemical microenvironment. Hyperuricemia predisposes to disease through the formation of urate crystals that cause gout, but hyperuricemia, independent of crystal formation, has also ...
So A, Thorens B
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Frontiers in Pharmacology, 2022 Hyperuricemia is the result of increased production and/or underexcretion of uric acid. Hyperuricemia has been epidemiologically associated with multiple comorbidities, including metabolic syndrome, gout with long-term systemic inflammation, chronic ...
Bendong Yang +13 more
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Cells, 2022 The OAT1 (SLC22A6) and OAT3 (SLC22A8) urate transporters are located on the basolateral membrane of the proximal renal tubules, where they ensure the uptake of uric acid from the urine back into the body.
Jiří Vávra +5 more
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Uric acid transporters hiding in the intestine [PDF]
Pharmaceutical Biology, 2016 Hyperuricaemia is known as an abnormally increased uric acid level in the blood. Although it was observed many years ago, since uric acid excretion via the intestine pathway accounted for approximately one-third of total elimination of uric acid, the molecular mechanism of 'extra-renal excretion' was poorly understood until the finding of uric acid ...
Xianxiang, Xu +3 more
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, 2022 We have read with interest the letter by Dr Wang [1] commenting on our article ‘The association of uric acid with mortality modifies at old age: data from the uric acid right for heart health (URRAH) study’ [2].
Borghi C +5 more
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