Hypouricemia and Urate Transporters [PDF]
Biomedicines, 2022 Hypouricemia is recognized as a rare disorder, defined as a serum uric acid level of 2.0 mg/dL or less. Hypouricemia is divided into an overexcretion type and an underproduction type.
Naoyuki Otani +4 more
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The impact of genetic variability in urate transporters on oxypurinol pharmacokinetics [PDF]
Clinical and Translational Science, 2023 The genetic determinants of the allopurinol dose‐concentration relationship have not been extensively studied. We aimed to clarify what factors, including genetic variation in urate transporters, influence oxypurinol pharmacokinetics (PKs).
Hailemichael Z. Hishe +6 more
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Frontiers in Pharmacology, 2023 Gout represents a metabolic ailment resulting from the accumulation of monosodium urate crystals within joints, causing both inflammation and, harm to tissues.
Xin Sun +10 more
exaly +3 more sources
Journal of Traditional Chinese Medical Sciences, 2019 Objective: Hyperuricemia is an excess of urate in blood. The kidneys play important parts in urate excretion, which involves handling reabsorption and secretion.
Zhijian Lin, Bing Zhang
exaly +3 more sources
Brassica rapa L. (Turnip) Ethanol Extract Alleviates Hyperuricemia by Modulating Purine Metabolism Enzymes and Renal Urate Transporters [PDF]
FoodsHyperuricemia (HUA) is a metabolic disorder caused by excessive uric acid (UA) production and/or insufficient UA excretion. Brassica rapa L. (turnip) is a traditional medicinal and edible plant in northwestern China.
Yan Wang +6 more
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Comprehensive phytochemical profiling of dealcoholized zhuyeqing liquor extract and its protective effect on hyperuricemia by regulating urate transporters and LPS/NLRP3 inflammasome pathway [PDF]
Frontiers in NutritionIntroductionHyperuricemia (HUA) is a major risk factor for gout and renal injury, underscoring the need for safe and effective natural dietary interventions.
Bingye Xu +10 more
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Urate transporters: Structural mechanisms and therapeutic opportunities in drug development [PDF]
Acta Pharmaceutica Sinica BQian Yang +5 more
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Advances in Urate Excretion and Urate Transporters in Hyperuricemia [PDF]
Zhongguo quanke yixue, 2023 Hyperuricemia is a heterogeneous disease caused by dysregulation of the homeostasis of urate production and excretion, which leads to the elevation of blood uric acid beyond the normal range.
XIN Jiadong, ZHOU Jiabao, WU Zhiyuan, ZHANG Xuming, GAO Jiandong
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Modulation of Urate Transport by Drugs
Pharmaceutics, 2021 Background: Serum urate (SU) levels in primates are extraordinarily high among mammals. Urate is a Janus-faced molecule that acts physiologically as a protective antioxidant but provokes inflammation and gout when it precipitates at high concentrations ...
Péter Tátrai +3 more
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Genetic and Physiological Effects of Insulin on Human Urate Homeostasis
Frontiers in Physiology, 2021 Insulin and hyperinsulinemia reduce renal fractional excretion of urate (FeU) and play a key role in the genesis of hyperuricemia and gout, via uncharacterized mechanisms. To explore this association further we studied the effects of genetic variation in
Asim K. Mandal +8 more
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