Results 21 to 30 of about 384,997 (202)

Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin on a High Fructose Corn Syrup-Induced Hyperuricemia Rat Model via the Amelioration of Urate Transporters and Inhibition of NLRP3 Inflammasome Signaling Pathway. [PDF]

open access: yesAntioxidants (Basel), 2021
Hyperuricemia is the main cause of gout and involved in the occurrence of many other diseases such as hyperlipidemia and hypertension correlated with metabolic disorders.
Chang YH   +8 more
europepmc   +2 more sources

Phyllanthi Fructus ameliorates hyperuricemia and kidney injure via inhibiting uric acid synthesis, modulating urate transporters, and alleviating inflammation. [PDF]

open access: yesSci Rep
Phyllanthi Fructus, known as Yuganzi (YGZ), is a unique medicine and food homologous fruit with both medicinal and nutritional properties. Its historical use in treating hyperuricemia (HUA) and gout is well-documented.
Liang S, Xu D, Wu J, Jiang Q, Zeng Y.
europepmc   +2 more sources

Examining the Association of Rare Allelic Variants in Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and Gout. [PDF]

open access: yesDis Markers
Genetic variations in urate transporters play a significant role in determining human urate levels and have been implicated in developing hyperuricemia or gout.
Vávra J   +7 more
europepmc   +2 more sources

Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in Rats. [PDF]

open access: yesMar Drugs, 2020
This study was designed to investigate the effects and underlying mechanisms of Astaxanthin (AST) on high-fructose-induced hyperuricemia (HUA) from the perspectives of the uric acid (UA) synthesis and excretion in rat models. Following six weeks of a 10%
Le Y   +7 more
europepmc   +2 more sources

New insight into the management of renal excretion and hyperuricemia: Potential therapeutic strategies with natural bioactive compounds

open access: yesFrontiers in Pharmacology, 2022
Hyperuricemia is the result of increased production and/or underexcretion of uric acid. Hyperuricemia has been epidemiologically associated with multiple comorbidities, including metabolic syndrome, gout with long-term systemic inflammation, chronic ...
Bendong Yang   +13 more
doaj   +1 more source

Modulation of genetic associations with serum urate levels by body-mass-index in humans [PDF]

open access: yes, 2015
We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants.
Döring, Angela   +999 more
core   +3 more sources

Function of Uric Acid Transporters and Their Inhibitors in Hyperuricaemia

open access: yesFrontiers in Pharmacology, 2021
Disorders of uric acid metabolism may be associated with pathological processes in many diseases, including diabetes mellitus, cardiovascular disease, and kidney disease. These diseases can further promote uric acid accumulation in the body, leading to a
Hao-lu Sun   +6 more
doaj   +1 more source

Fucoidan from Laminaria japonica Inhibits Expression of GLUT9 and URAT1 via PI3K/Akt, JNK and NF-κB Pathways in Uric Acid-Exposed HK-2 Cells

open access: yesMarine Drugs, 2021
This work aimed to investigate the effect of fucoidan (FPS) on urate transporters induced by uric acid (UA). The results showed that UA stimulated the expression of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) in HK-2 cells, and FPS ...
Yu Zhang   +8 more
doaj   +1 more source

Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank

open access: yesAnnals of the Rheumatic Diseases, 2021
Objectives To perform a genome-wide association study (GWAS) of gout cases versus asymptomatic hyperuricaemia (AH) controls, and gout cases versus normouricaemia controls, and to generate a polygenic risk score (PRS) to determine gout-case versus AH ...
Gabriela Sandoval-Plata   +2 more
semanticscholar   +1 more source

Transporter-centric view of urate metabolism: From genome-wide association study to pathophysiology

open access: yesJournal of Physical Fitness and Sports Medicine, 2012
While urate is an important anti-oxidant molecule in the body, high plasma levels of urate cause morbidity including urate crystal deposition in joints (gout) and stone formation in the urinary tract. Because urate is an end product of purine metabolism,
Hiroyuki Sakurai
doaj   +1 more source

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