Results 31 to 40 of about 384,997 (202)

Predicting anti-hyperuricemic and anti-gouty activities of fatty acids from Limonia acidissima L. fruit: In silico–in vivo study [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: As of today, the knowledge of the role of nutraceuticals in treating metabolic diseases such as hyperuricemia is still limited. Aims: To evaluate the mechanisms of anti-hyperuricemic and anti-gouty activity of Limonia acidissima in silico and
Rika Yusnaini, Ikhsan, Salfauqi Nurman, Rinaldi Idroes, Teti Arabia, Nurdin Saidi, Rosnani Nasution   +6 more
doaj   +1 more source

The Therapeutic Effect and the Potential Mechanism of Flavonoids and Phenolics of Moringa oleifera Lam. Leaves against Hyperuricemia Mice

Molecules, 2022
The aim of this study is to evaluate the anti-hyperuricemia effect and clarify the possible mechanisms of flavonoids and phenolics of MOL (MOL-FP) in mice.
Xiaowei Luo, Lipeng Zhou, Shukai Wang, Jing Yuan, Zihao Chang, Qian Hu, Yinxin Chen, Yuqi Liu, Ya Huang, Baojin Wang, Ye Gao, Zhaohui Wang, Yitong Cui, Yue Liu, Lanzhen Zhang   +14 more
doaj   +1 more source

Molecular mechanisms regulating uric acid metabolism in the human intestine, systematic literature review

Современная ревматология, 2023
This review presents recent data on direct and indirect pathogenetic relationships between metabolism of purine compounds and biochemical processes in cells of the digestive system. A comprehensive analysis of available modern publications for the period
N. A. Konyshko, G. S. Konyshko
doaj   +1 more source

Pathophysiology of urate transporters in primary gout [PDF]

, 2021
There are localised proteins (so-called urate transporters) in the renal proximal tubules and in the intestine, which excrete and reabsorb uric acid. Polymorphisms in the genes coding these proteins can result in the disruption of the transport function ...
Pavelcová, Kateřina
core  

Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains [PDF]

, 2020
香川大学Kagawa University博士（医学）Abstract It has been suggested that urate plays a protective role in neurons, while hyperuricemia is correlated with atherosclerosis and cardiovascular disease.
Uemura, Naoya, 植村, 直哉, ウエムラ, ナオヤ   +2 more
core   +1 more source

Identification of a dysfunctional exon-skipping splice variant in GLUT9/SLC2A9 causal for renal hypouricemia type 2

Frontiers in Genetics, 2023
Renal hypouricemia (RHUC) is a pathological condition characterized by extremely low serum urate and overexcretion of urate in the kidney; this inheritable disorder is classified into type 1 and type 2 based on causative genes encoding physiologically ...
Yu Toyoda, Sung Kweon Cho, Sung Kweon Cho, Velibor Tasic, Kateřina Pavelcová, Jana Bohatá, Hiroshi Suzuki, Victor A. David, Jaeho Yoon, Anna Pallaiova, Jana Šaligová, Darryl Nousome, Raul Cachau, Cheryl A. Winkler, Tappei Takada, Blanka Stibůrková, Blanka Stibůrková, Blanka Stibůrková   +17 more
doaj   +1 more source

Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels [PDF]

, 2018
Elevated serum urate levels can cause gout, an excruciating disease with suboptimal treatment. Previous GWAS identified common variants with modest effects on serum urate.
Chu, AY, Duijn, C.M. (Cornelia) van, Ciullo, M., Boerwinkle, E. (Eric), Li, Y., Nutile, T. (Teresa), van Rooij, J., Nutile, Teresa, Chen, Ming-Huei, Chen, MH, McKnight, Barbara, Yang, Qiong, Yang, Q, Boerwinkle, E., Uitterlinden, André; id_orcid, Morrison, A.C. (Alanna), Morrison, A., Kraaij, R. (Robert), Köttgen, A. (Anna), Amin, Najaf, Robinson-Cohen, C. (Cassianne), Woodward, Owen M, Liu, J., Amin, N. (Najaf), Kutalik, Z, Mace, A. (Aurelien), Köttgen, A., Fox, CS, Swen, M., Yang, Q. (Qiong Fang), Huffman, J.E., Yang, Q., Kraaij, Robert, van Duijn, C.M., Huffman, JE, Woodward, O.M., Vollenweider, Peter, Kraaij, Robert; id_orcid, Uitterlinden, A.G. (André), Morrison, A, Dehghan, A. (Abbas), Sedaghat, Sanaz, Uitterlinden, André G, Nutile, T, Li, Yi, Demirkan, A., Woodward, O.M. (Owen), Boerwinkle, Eric, Vollenweider, P., Dehghan, Abbas, Chu, A.Y., Yu, B. (Bing), Swen, Melody, Robinson-Cohen, C., Sorice, Rossella, Köttgen, Anna, Swen, M. (Melody), Brody, JA, Psaty, Bruce M, Brody, J.A., Boerwinkle, E, Tin, A, Dehghan, A., Yu, Bing, Teumer, A., Ghasemi, S. (Sahar), Huffman, J.E. (Jennifer E.), Nutile, T., Tin, Adrienne, Teumer, A. (Alexanda), Uitterlinden, A.G., Chu, Audrey Y, Swen, M, Kraaij, R., Sedaghat, S., Tin, A. (Adrienne), Teumer, A, Demirkan, Ayşe, Sedaghat, S. (Sanaz), Li, Meng, Amin, N., Li, Yong, Chen, M.-H. (Ming-Huei), Yu, B, Fox, C.S., Morrison, Alanna, Ciullo, M, Psaty, BM, Kutalik, Z., McKnight, B, Ghasemi, S., Liu, Jun, Li, M., Tin, A., Sorice, R., Robinson-Cohen, Cassianne, Psaty, B.M. (Bruce M.), Macé, Aurélien, Psaty, B.M., Brody, J.A. (Jennifer A.), Yu, B., Woodward, OM, Ciullo, Marina, Duijn, Cornelia, McKnight, B., van Rooij, Jeroen, Li, M. (Meng), Ghasemi, S, Li, M, Ciullo, M. (Marina), Chen, M.H., Sorice, R, Kutalik, Zoltán, Macé, A., Rooij, J.G.J. (Jeroen) van, Vollenweider, P, Chu, A.Y. (Audrey Y), Liu, J. (Jun), Huffman, Jennifer E, van Duijn, Cornelia M, Ghasemi, Sahar, Vollenweider, P. (Peter), Kutalik, Z. (Zoltán), Teumer, Alexanda, Li, Y. (Yong), Fox, C.S. (Caroline), McKnight, B. (Barbara), Demirkan, A. (Ayşe), Brody, Jennifer A, Robinson-Cohen, C, Fox, Caroline S, Psaty BM, Uitterlinden AG, Najaf Amin, Ghasemi S, Sanaz Sedaghat, Sorice R, Bruce M. Psaty, Kottgen A, Ciullo M, Morrison A, Aurélien Macé, Bing Yu, McKnight B, Sahar Ghasemi, Peter Vollenweider, Huffman JE, Fox CS, Alanna Morrison, Yong Li, Jennifer A. Brody, Caroline S. Fox, Yu B, Chen MH, Vollenweider P, Adrienne Tin, Tin A, Owen M. Woodward, Sedaghat S, Melody Swen, Woodward OM, Li M, van Duijn CM, Li Y, Abbas Dehghan, Zoltán Kutalik, Jeroen van Rooij, Liu J, Marina Ciullo, Woodward, Owen M., Audrey Y. Chu, Ming-Huei Chen, Robinson-Cohen C, Dehghan A, Barbara McKnight, Jennifer E. Huffman, Amin N, Swen M, Mace A, Teresa Nutile, Qiong Yang, Jun Liu, Demirkan A, Cornelia M. van Duijn, Teumer A, Meng Li, van Rooij J, Boerwinkle E, Chu AY, Anna Köttgen, RobinsonCohen C, Alexanda Teumer, Ayşe Demirkan, Brody JA, Robert Kraaij, Yang Q, Rossella Sorice, Kutalik Z, Nutile T, Eric Boerwinkle, André G. Uitterlinden, Cassianne Robinson-Cohen, Kraaij R, Mace, A, Kottgen, A, van Rooij, J   +205 more
core   +2 more sources

Morin Improves Urate Excretion and Kidney Function through Regulation of Renal Organic Ion Transporters in Hyperuricemic Mice

Journal of Pharmacy & Pharmaceutical Sciences, 2010
Purpose. Morin (3,5,7,2′,4′-pentahydroxyflavone), a plant-derived flavonoid, has beneficial effects in animals with various diseases including hyperuricemia and renal dysfunction.
Cai-Ping Wang, Xing Wang, Xian Zhang, Yun-Wei Shi, Lei Liu, Ling-Dong Kong   +5 more
doaj   +1 more source

Differential gene expression of ABCG2, SLC22A12, IL-1β, and ALPK1 in peripheral blood leukocytes of primary gout patients with hyperuricemia and their comorbidities: a case–control study

European Journal of Medical Research, 2022
Background The ABCG2, SLC22A12, and ALPK1 genes have been strongly associated with dysfunction of urate metabolism in patients with gout, but it is unknown how these transporters are expressed in patients with acute or chronic gout.
Paniagua-Díaz Natsuko, Sanchez-Chapul Laura, Clavijo-Cornejo Denise, Ventura-Ríos Lucio, Aguilar-Salinas Carlos, Sanchez-Muñoz Fausto, López-Macay Ambar   +6 more
doaj   +1 more source

Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion

Frontiers in Pharmacology, 2020
Hyperuricemia is characterized by abnormally high level of circulating uric acid in the blood and is associated with increased risk of kidney injury. The pathophysiological mechanisms leading to hyperuricemic nephropathy (HN) involve oxidative stress ...
Xuechen Li, Xuechen Li, Zhenxin Yan, Mattias Carlström, Jinying Tian, Xiaolin Zhang, Wenxuan Zhang, Song Wu, Fei Ye   +8 more
doaj   +1 more source