Results 41 to 50 of about 384,997 (202)

Functional characterization of urate handling by hSLC2A9 (hGLUT9) splice variants in a heterologous expression system [PDF]

, 2012
Multiple, independent Genome Wide Association Studies have uncovered a significant correlation between abnormal plasma urate levels and single nucleotide polymorphisms within the hSLC2A9 gene.
Witkowska, Katarzyna
core   +1 more source

Sex Differences in Urate Handling

, 2020
Hyperuricemia, or elevated serum urate, causes urate kidney stones and gout and also increases the incidence of many other conditions including renal disease, cardiovascular disease, and metabolic syndrome.
Owen M. Woodward, Victoria L. Halperin Kuhns   +1 more
core   +1 more source

The Role of the Intestine in the Development of Hyperuricemia

Frontiers in Immunology, 2022
Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints. Hyperuricemia is the fundamental factor of gout.
Hui Yin, Hui Yin, Na Liu, Na Liu, Jie Chen, Jie Chen   +5 more
doaj   +1 more source

Mendelian randomization of serum urate and parkinson disease progression [PDF]

, 2014
ObjectiveHigher serum urate concentrations predict more favorable prognosis in individuals with Parkinson disease (PD). The purpose of this study was to test the causality of this association using a Mendelian randomization approach.MethodsThe study was ...
Gao, Xiang, Tanner, Caroline M, Schwarzschild, Michael A, Stanley Fahn, Shoulson, Ira, Caroline M. Tanner, Alberto Ascherio, Michael A. Schwarzschild, Ascherio, Alberto, Shirley Eberly, Xiang Gao, David Oakes, Ira Shoulson, Kelly Claire Simon, Oakes, David, Simon, Kelly Claire, Fahn, Stanley, Group, on behalf of the Parkinson Study, Eberly, Shirley   +18 more
core   +1 more source

Gout associated with reduced renal excretion of uric acid. Renal tubular disorder that nephrologists do not treat

Nefrología (English Edition), 2022
Gout is recurrent inflammatory arthritis caused by the deposition of monosodium urate crystals in the joints. The risk factors that predispose to suffering from gout include non-modifiable factors such as gender, age, ethnicity and genetics, and ...
Víctor M. García-Nieto, Félix Claverie-Martín, Teresa Moraleda-Mesa, Ana Perdomo-Ramírez, Patricia Tejera-Carreño, Elizabeth Cordoba-Lanus, María I. Luis-Yanes, Elena Ramos-Trujillo   +7 more
doaj   +1 more source

The role of urate and xanthine oxidase in vascular oxidative stress:Future directions [PDF]

, 2009
Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high.
Allan Struthers, Jacob George, George, Jacob, Struthers, Allan   +3 more
core   +1 more source

La gota asociada a reducción de la excreción renal de ácido úrico. Esa tubulopatía que no tratamos los nefrólogos

Nefrología, 2022
Resumen: La gota es una artritis inflamatoria recurrente provocada por el depósito de cristales de urato monosódico en las articulaciones. Entre los factores de riesgo que predisponen a padecer gota se encuentran aquellos no modificables como sexo, edad,
Víctor M. García-Nieto, Félix Claverie-Martín, Teresa Moraleda-Mesa, Ana Perdomo-Ramírez, Patricia Tejera-Carreño, Elizabeth Córdoba-Lanus, María I. Luis-Yanes, Elena Ramos-Trujillo   +7 more
doaj   +1 more source

Correction: Stevia residue extract increases intestinal uric acid excretion via interactions with intestinal urate transporters in hyperuricemic mice.

Food & Function, 2020
Correction for 'Stevia residue extract increases intestinal uric acid excretion via interactions with intestinal urate transporters in hyperuricemic mice' by Arshad Mehmood et al., Food Funct., 2019, 10, 7900-7912.
A. Mehmood, Lei Zhao, Cheng-Tao Wang, I. Hossen, R. N. Raka, Huimin Zhang   +5 more
semanticscholar   +1 more source

Identification of three distinct cell populations for urate excretion in human kidneys

Journal of Physiological Sciences
In humans, uric acid is an end-product of purine metabolism. Urate excretion from the human kidney is tightly regulated by reabsorption and secretion. At least eleven genes have been identified as human renal urate transporters.
Yoshihiko M. Sakaguchi, Pattama Wiriyasermkul, Masaya Matsubayashi, Masaki Miyasaka, Nau Sakaguchi, Yoshiki Sahara, Minoru Takasato, Kaoru Kinugawa, Kazuma Sugie, Masahiro Eriguchi, Kazuhiko Tsuruya, Hiroki Kuniyasu, Shushi Nagamori, Eiichiro Mori   +13 more
doaj   +1 more source

Ionic Gating of Liquid‐Crystal‐Like Pteridine Assemblies Enables Tunable Light Scattering

Advanced Materials, EarlyView.
Tunable optical properties emerge through developmentally regulated ionic gating, which transforms disordered, ultraviolet (UV)‐absorbing organelles into concentrically ordered, liquid‐crystal‐like light scatterers. By integrating analyses of pteridine composition, potassium‐dependent assembly, hierarchical ultrastructure, and optical behavior, the ...
Sourabh Bera, Zohar Eyal, Yael Noy, Yuval Barzilay, Siddharth Sahoo, Srikant Moharana, Avi Baram, Tali Lerer‐Goldshtein, Neta Varsano, Bar Bader, Lothar Houben, Uwe Heinig, Iddo Pinkas, Moshe Goldsmith, Tamar Unger, Shira Albeck, Andrea Sorrentino, Maxim Itkin, Sergey Malitsky, Ziv Porat, Ido Hadar, Venkata Jayasurya Yallapragada, Dvir Gur   +22 more
wiley   +1 more source