Results 61 to 70 of about 384,997 (202)

Nature of urate transport in isolated rabbit proximal tubules

, 1981
Unidirectional fluxes of [14C]-urate from bath to lumen and from lumen to bath were measured in isolated perfused rabbit proximal tubules. The absorption of urate from the perfusate was small in magnitude and relatively insensitive to alteration by ...
R. Edwards, A. Shimomura, R. Tanner, J. Grantham, A. Chonko   +4 more
core   +1 more source

Gout.

, 2023
To the Editor: The Clinical Practice review on gout by Mikuls (Nov. 17 issue)1 underscores the importance of hyperuricemia as a necessary risk factor and mentions the high heritability of serum urate levels.2 Serum urate levels are mostly controlled by ...
Olinger, Eric, Devuyst, Olivier, Köttgen, Anna   +2 more
core   +1 more source

Functional food in relation to gout arthritis

Heliyon
Gouty arthritis is a crystal-induced inflammatory disease driven by hyperuricemia and monosodium urate (MSU) crystal deposition. Although pharmacological urate-lowering and anti-inflammatory therapies are effective, adverse effects, poor adherence, and ...
Yedi Herdiana
doaj   +1 more source

The Hidden Effects of Company Strikes: Workers Made Idle in UK Engineering and Metalworking From 1920 to 1970

LABOUR, EarlyView.
ABSTRACT This study examines a neglected aspect of industrial relations: workplace disputes in which workers are incidentally made idle because of strike actions of others. These spillover effects have received little systematic attention despite potentially accounting for a substantial share of the employment consequences of industrial conflict.
Robert A. Hart, Carl Singleton
wiley   +1 more source

A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression.

, 2018
The precise molecular mechanisms by which urate-associated genetic variants affect urate levels are unknown. Here, we tested for functional linkage of the maximally associated genetic variant rs1967017 at the PDZK1 locus to elevated PDZK1 expression.
Phipps-Green, Amanda J, Horsfield, Julia A, Leask, Megan, Ketharnathan, Sarada, Boocock, James, Antony, Jisha, Merriman, Tony R, O'Sullivan, Justin M   +7 more
core   +1 more source

The pathogenesis of gout

Journal of Rheumatic Diseases
Gout is the most common inflammatory arthritis in adults, associated with hyperuricemia and the chronic deposition of monosodium urate (MSU) crystals. Hyperuricemia results from increased production of uric acid and decreased excretion by the kidneys and
Eun Young Ahn, Min Wook So
doaj   +1 more source

Uremic Toxins in Organ Crosstalk

Frontiers in Medicine, 2021
Many putative uremic toxins—like indoxyl sulfate, p-cresol sulfate, kynurenic acid, uric acid, and CMPF—are organic anions. Both inter-organ and inter-organismal communication are involved.
Jerome Lowenstein, Sanjay K. Nigam
doaj   +1 more source

TMEM16A Ca2+‐activated Cl− channel: Functional interactions with cytoskeletal and membrane‐associated proteins

The Journal of Physiology, EarlyView.
Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Aya Yamamura   +4 more
wiley   +1 more source

Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4α

, 2014
Renal tubular handling of urate is realized by a network of uptake and efflux transporters, including members of drug transporter families such as solute carrier proteins and ATP-binding cassette transporters.
Kroemer, Heyo K., Meyer zu Schwabedissen, Henriette, Feldtmann, Rico, Wolf, Stephanie, Zimmermann, Uwe, Prestin, Katharina, Meyer zu Schwabedissen, Henriette E., Hussner, Janine, Geissler, Ingrid, Rimmbach, Christian, Wolf S, Rimmbach C, Hussner J, Geissler I, Zimmermann U, Feldtmann R, Meyer zu Schwabedissen HE, Prestin K, Kroemer HK   +18 more
core   +1 more source

Exploring the Mechanism of a Chrysanthemum Compound Formula in Treating Hyperuricemia by Integrating Network Pharmacology with Experimental Validation

Shipin gongye ke-ji
Objective: Hyperuricemia (HUA) is a metabolic disorder characterized by abnormally elevated serum uric-acid levels. This study investigated the inhibitory effect of a chrysanthemum compound formula (CCF) on xanthine oxidase (XOD) in vitro and further ...
Xingjian MENG, Xiaoran YU, Pei YIN, Jian TONG, Shuang LIU, Qiannan WANG, Feng GAO, Yunfeng BI, Heyu WANG   +8 more
doaj   +1 more source