Results 81 to 90 of about 384,997 (202)

Weighted Single‐Step GWAS Reveals Genetic Mechanisms Underlying Pregnancy Loss in Early Nellore Heifers

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Pregnancy loss (PL) affects reproductive efficiency in beef cattle, yet its genetic architecture remains poorly understood in Bos indicus populations. Here, PL was defined as failure from pregnancy diagnosis to calving, capturing a window approximately 60 days after the breeding season.
Flávia C. Bis, Nedenia Bonvino Stafuzza, Elisângela Chicaroni de Mattos, Angélica Simone Cravo Pereira, José Bento Sterman Ferraz, Fernando Baldi, Sabrina T. Amorim   +6 more
wiley   +1 more source

Hederagenin's uric acid-lowering effects in hyperuricemic mice: Mechanistic insights from molecular docking and in vivo analysis.

PLoS ONE
This study explored the uric acid-lowering effects of hederagenin (HD) through molecular docking analysis and a chronic hyperuricemia (HUA) mouse model.
Ping Chen, Ya-Ni Tian, Jing-Tao Wang, Xiang-Lin Yin, Bao-Sheng Guan, Xue Bai   +5 more
doaj   +1 more source

Strategies to reduce uric acid through gut microbiota intervention

Frontiers in Microbiology
Hyperuricaemia (HUA) is a metabolic disorder resulting from the dysregulation of purine metabolism. It is closely associated with gout and various metabolic syndromes, representing an increasing global public health challenge.
Yueying Cui, Peiyu An, Feng Li, Fengsen Duan, Zusong Mei, Qiao Ye, Guangyun Wang, Haitao Zhang, Yuan Luo   +8 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, Volume 67, Issue 10, Page 5042-5074, October 2026.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Eggshell Membrane Ameliorates Hyperuricemia by Increasing Urate Excretion in Potassium Oxonate-Injected Rats

, 2021
Hyperuricemia is the primary cause of gouty arthritis and other metabolic disorders. Eggshell membrane (EM) is an effective and safe supplement for curing pain and stiffness connected with osteoarthritis.
Dong-Seon Kim, Yoon-Young Sung
core   +1 more source

Nephropathogenic infectious bronchitis virus induces epithelial-mesenchymal transition of renal tubular epithelial cells through the TGF-β/p-P38 pathway causing uric acid excretion disorder in chickens

Journal of Virology
Nephropathogenic infectious bronchitis virus (NIBV) infection usually causes kidney enlargement and urate deposition in chickens, leading to sudden death.
Yunfeng Chen, Yan Shi, Cheng Huang, Haoyu Huang, Yizhou Zeng, Gaofeng Cai, Zhanhong Zheng, Ping Liu, Xiaona Gao, Xiaoquan Guo   +9 more
doaj   +1 more source

A Post–NGP Mitsuokella jalaludinii as a Therapeutic Candidate for Gout

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Schematic summary of the therapeutic mechanisms and evaluation of the post–NGP strain M. jalaludinii PMC73 for gout. PMC73 demonstrated uric acid–lowering efficacy through purine catabolism and hypoxanthine utilization, along with intracellular uric acid reduction in macrophages.
Mohammed Solayman Hossain, Sukyung Kim, Md Tareque Aziz, Izaz Ahmed, Md Sarower Hossen Shuvo, Hyewon Yang, Yunjeong Jang, Minseo Kim, Seohyeon Jang, Yusol Kim, Soeun Oh, Yunseo Nam, Hoonhee Seo, Ho‐Yeon Song   +13 more
wiley   +1 more source

Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney

Arthritis Research & Therapy, 2016
BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
J. Miner, P. Tan, D. Hyndman, Sha Liu, C. Iverson, Payal Nanavati, D. Hagerty, Kimberly Manhard, Zan-Cong Shen, J. Girardet, L. Yeh, R. Terkeltaub, B. Quart   +12 more
semanticscholar   +1 more source

Effects of multiple genetic loci on the pathogenesis from serum urate to gout

, 2017
Gout is a common arthritis resulting from increased serum urate, and many loci have been identified that are associated with serum urate and gout. However, their influence on the progression from elevated serum urate levels to gout is unclear. This study
Shuai Jiang, Hongjun He, Hengdong Ji, Dongbao Zhao, Yajun Yang, Li Jin, Jiucun Wang, Jingru Zhou, Yuan Li, Yanyun Ma, Yi Wang, Chengde Yang, Yafei Pang, Xiaofeng Wang, Xia Xu, Zheng Dong, Hejian Zou   +16 more
core   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source