Results 101 to 110 of about 384,997 (202)

Characterization of Urate Transport System in JAR and JEG-3 Cells, Human Trophoblast-derived Cell Lines [PDF]

Urate (uric acid) is the major inert end product of purine metabolism in humans. Since it is water soluble, it requires a membranous protein called transporter for its permeation across the plasma membrane.
Ouchi, Motoshi, Fukasawa, Ichio, Fujita, Tomoe, Jutabha, Promsuk, Otani, Naoyuki, Anzai, Naohiko, Morita, Asuka, Kiuchi, Kaori, Nohara, Masakatsu   +8 more
core   +1 more source

Renal Urate Transporters are Targets for Inhibitory Effect of Febuxostat, a Non-purine Xanthine Oxidase Inhibitor

GOUT AND NUCLEIC ACID METABOLISM, 2017
inhibitor, is an effective drug superior to allopurinol for treatment of hyperuricemia, a risk factor of hypertension and cardiovascular diseases. In addition to its XO inhibitory effect, we aim to test its action on renal urate transporters URAT1 ...
Promsuk Jutabha, Motoshi Oouchi, N. Anzai   +2 more
semanticscholar   +1 more source

Tubule urate and PAH transport: sensitivity and specificity of serum protein inhibition

, 1987
Macromolecules in rabbit serum inhibit the cellular uptake and transepithelial secretion of [14C]urate and p-[3H]aminohippurate ([3H]PA) in rabbit S2 proximal tubule segments.
B. Cowley, J. J. Grantham, J. Kennedy
core   +1 more source

Pu-erh ripened tea resists to hyperuricemia through xanthine oxidase and renal urate transporters in hyperuricemic mice

, 2017
To investigate the effects of Pu-erh ripened tea on lowering uric acid levels and identify its possible mechanisms, three different doses of the tea, with allopurinol as a positive control, were administered intragastrically to hyperuricemic mice ...
R. Zhao, Dong Chen, Hua-Ling Wu
semanticscholar   +1 more source

Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain

Fluids and Barriers of the CNS, 2016
Uric acid (UA) is known to exert neuroprotective effects in the brain. However, the mechanism of UA regulation in the brain is not well characterized. In our previous study, we described that the mouse urate transporter URAT1 is localized to the cilia ...
Naoko H. Tomioka, Yoshifuru Tamura, T. Takada, S. Shibata, Hiroshi Suzuki, S. Uchida, M. Hosoyamada   +6 more
semanticscholar   +1 more source

ABC transporters in Dictyostelium discoideum development [PDF]

, 2013
ATP-binding cassette (ABC) transporters can translocate a broad spectrum of molecules across the cell membrane including physiological cargo and toxins.
Adam Kuspa, Gad Shaulsky (10030), Toplak Marko, Balaji Santhanam, Zhuchenko Olga, Adam Kuspa (45348), Marko Toplak, Gad Shaulsky, Shaulsky, Gad, Miranda Edward Roshan, Balaji Santhanam (155206), Zupan Blaz, Santhanam, Balaji, Kuspa Adam, Zupan, Blaz, Edward Roshan Miranda (446004), Marko Toplak (446006), Zhuchenko, Olga, Edward Roshan Miranda, Blaz Zupan (10031), Miranda, Edward Roshan, Olga Zhuchenko, Kuspa, Adam, Blaz Zupan, Olga Zhuchenko (446005), Santhanam Balaji, Shaulsky Gad, Toplak, Marko   +27 more
core   +2 more sources

Solving the mysteries of urate transport: structural insights into GLUT9 and URAT1

Acta Materia Medica
Recent groundbreaking advances in the structural biology of the glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) have provided critical insights into the molecular mechanisms underlying urate recognition and transport.
Mei Wang, Shujing Xu, Xiaoyu Shi, Edeildo Ferreira da Silva-Júnior, Peng Zhan   +4 more
doaj   +1 more source

Mechanism of Action of Limosilactobacillus fermentum FOSU-YHD19 in Alleviating Hyperuricemia [PDF]

Shipin Kexue
Objective: To investigate the mechanism underlying the uric acid-lowering effect of Limosilactobacillus fermentum FOSU-YHD19 (L. fermentum YHD19) at the cellular level. Methods: A hyperuricemic cell model was established using HK-2 cells.
HUANG Jiayi, LU Yunhui, HUANG Fang, WU Weitong, WANG Langhong, XIONG Jie, HUANG Yanyan
doaj   +1 more source

A ‘complexity’ of urate transporters

, 2010
Genetic variation in the SLC2A9 gene is a new genetic risk factor for low fractional excretion of uric acid, hyperuricemia, and gout. Its gene product, GLUT9, was previously known as a type II glucose/fructose transporter but is now known to function as ...
Nicholas D. Hastie, Harry Campbell, Igor Rudan, Alan F. Wright   +3 more
core   +1 more source

Polydatin alleviates hyperuricemia combined with gouty arthritis in mice via regulating urate transporters, NLRP3 inflammasome and NF-κB pathway

Journal of Functional Foods, 2023
Wenjing Xu, Yu-Feng Chen, Fenfen Li, Xiao-Xi Zhang, Cantao Li, Chenxi Wu, Yan Huang, Daozong Xia   +7 more
semanticscholar   +1 more source