Results 121 to 130 of about 384,997 (202)

Evodiamine attenuates hyperuricemia-associated gouty arthritis and renal injury through urate-inflammatory axis modulation

Frontiers in Immunology
BackgroundTherapeutic options for hyperuricemia (HUA) and its complications remain inadequate, particularly when gouty arthritis (GA) and hyperuricemic nephropathy (HN) coexist.
Yu Mou, Wenhao Liao, Qun Niu, Xue Zhan, Tianxin Zhang, YuChen Li, Hong Che, Peijia Liu, Xiangdong Yang, Jianyuan Tang, Jianyuan Tang, Zhilei Wang   +11 more
doaj   +1 more source

Overview of pharmacodynamical research of traditional Chinese medicine on hyperuricemic nephropathy: from the perspective of dual-regulatory effect on the intestines and kidneys

Frontiers in Pharmacology
Uncontrolled hyperuricemia contributes to chronic kidney disease, characterized by renal inflammatory cell infiltration and tubulointerstitial fibrosis, eventually leading to renal failure.
Ting Wang, Ting Wang, Li Li, Li Liu, Ruirong Tan, Qinxuan Wu, Xin Zhu, Hua Hua, Ying Dai, Huan Li, Jiuzhou Mao, Junning Zhao, Junning Zhao, Zhujun Yin, Zhujun Yin   +14 more
doaj   +1 more source

Urate secretion in isolated rabbit renal tubules

, 1980
The flux of radioactive urate from bath to lumen was measured in isolated proximal convoluted (PCT), proximal straight (PST), and cortical collecting tubules (CCT).
A. M. Chonko
core   +1 more source

Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains

It has been suggested that urate plays a protective role in neurons, while hyperuricemia is correlated with atherosclerosis and cardiovascular disease.
Uemura, Naoya, 植村, 直哉, ウエムラ, ナオヤ   +2 more
core  

Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux

, 2003
Background/Aims: Renal secretion of organic anions is critically dependent on their basolateral uptake against the electrochemical gradient. Due to their localization, two transporters are likely involved, namely OAT1 and OAT3. While OAT1 as an exchanger
Burckhardt, Gerhard, Bahn, A., Bakhiya, N., Wolff, Natascha A.   +3 more
core   +1 more source

Molecular Mechanism of the Urate-lowering Effects of Calcium Channel Blockers [PDF]

Hyperuricemia has recently been recognized as one of the risk factors for cardiovascular diseases. Some calcium channel blockers(CCBs), commonly used in the treatment of hypertension, have been reported to decrease serum urate level.
Tanaka-nakadate, Sawako, Ouchi, Motoshi, Fukuda, Hirotsugu, Hori, Takayuki, Jutabha, Promsuk, Onizawa, Nobuyuki, Otani, Naoyuki, Anzai, Naohiko, Oba, Toru, Tsuchiya, Go, Iseki, Tatou, Hayashi, Keitaro   +11 more
core   +1 more source

Ameliorative action of “daitongxiao” against hyperuricemia includes the “uric acid transporter group”

Frontiers in Pharmacology
This study aimed to investigate the potential mechanisms involved in the therapeutic effects of daitongxiao (DTX) on hyperuricemia (HUA). DTX was administered to two animal models of HUA via gavage feeding: HUA quail model (a uricotelic animal with urate
Lijie Zheng, Yuanmei Bai, Yan Wan, Feifan Liu, Yuhuan Xie, Jinglin He, Peixin Guo   +6 more
doaj   +1 more source

Establishment and optimization of a novel mouse model of hyperuricemic nephropathy

Renal Failure
Hyperuricemia is a metabolic disorder characterized by elevated serum uric acid levels. Soluble urate can activate immune responses, and the excessive accumulation of urate in the kidneys results in hyperuricemic nephropathy (HN). However, the lack of an
Jiamin Wang, Rong Chen, Kaireng Wu, Juxian Mo, Minghui Li, Zhe Chen, Guixiang Wang, Ping Zhou, Tian Lan   +8 more
doaj   +1 more source

Hyperuricemia and its related diseases: mechanisms and advances in therapy

Signal Transduction and Targeted Therapy
Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic syndrome, and diabetes, etc.
Lin Du, Yao Zong, Haorui Li, Qiyue Wang, Lei Xie, Bo Yang, Yidan Pang, Changqing Zhang, Zhigang Zhong, Junjie Gao   +9 more
doaj   +1 more source

Brassica rapa L. Ethanol Extract Alleviates Hyperuricemia by Modulating Purine Metabolism Enzymes and Renal Urate Transporters

Hyperuricemia (HUA) is a metabolic disorder caused by excessive uric acid (UA) production and/or insufficient UA excretion. Brassica rapa L. is a biennial crop widely cultivated in northwestern China. In this study, the urate-lowering effects of Brassica
Kai Yang, Wenwu Yao, Yinghao Liu, Abdulla Yusuf, Yan Wang, Yuheng Yang, Dongyuan Cheng   +6 more
core   +1 more source