Results 111 to 120 of about 384,997 (202)

Complex Analysis of Urate Transporters SLC2A9, SLC22A12 and Functional Characterization of Non-Synonymous Allelic Variants of GLUT9 in the Czech Population: No Evidence of Effect on Hyperuricemia and Gout

PLoS ONE, 2014
Objective Using European descent Czech populations, we performed a study of SLC2A9 and SLC22A12 genes previously identified as being associated with serum uric acid concentrations and gout.
O. Hurba, Andrea Mančíková, V. Krylov, M. Pavlíková, K. Pavelka, B. Stibůrková   +5 more
semanticscholar   +1 more source

Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a Greater Extent than Benzbromarone s [PDF]

, 2020
Urate-lowering therapy is indispensable for the treatment of gout, but available drugs do not control serum urate levels tightly enough. Although the uricosurics benzbromarone and probenecid inhibit a urate reabsorption transporter known as renal urate ...
Jumpei Kiyokawa, June Kyoung, Ki Hwan Lee, Sung Oh Ahn, Horiba, Mizuki Yamane, Yoshiki Tanaka, Jo Kim, Naoshi Kawabe, Byung Ho Kim, Toshito Nakagawa, Shuichi Ohtomo   +11 more
core  

Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia

Communications Biology
Decreased renal uric acid excretion is a major contributor to hyperuricemia (HUA), but its underlying mechanism remains unclear. Here, we identify cathepsin B (CTSB) as a key regulator of urate handling in HUA.
Huagang Lin, Linjing Nie, Deping Wu, Dexian Zhang, Rui Peng, Sijie Tao, Zhibin Ye, Sibo Zhu, Maoqing Ye, Jing Xiao   +9 more
doaj   +1 more source

The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease [PDF]

, 2018
The SLC22 transporter family consists of more than two dozen members, which are expressed in the kidney, the liver, and other tissues. Evolutionary analysis indicates that SLC22 transporters fall into at least six subfamilies: OAT (organic anion ...
Nigam, Sanjay K, Sanjay K. Nigam
core   +1 more source

Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter

, 2019
Background: Soluble uric acid stimulates vascular smooth muscle cell (VSMC) proliferation by activating mitogen-activated protein kinases, and stimulating COX-2 and PDGF synthesis. The mechanism by which uric acid enters the VSMC is not known.
강덕희
core   +1 more source

Plant ABC transporters [PDF]

, 2000
The ATP binding cassette (ABC) superfamily is a large, ubiquitous and diverse group of proteins, most of which mediate transport across biological membranes.
Theodoulou, F. L., Theodoulou, Freddie
core   +1 more source

The Effect of Decrease in Serum Urate for the Risk of Gout Flares During Urate-Lowering Therapy Initiation Among Chinese Male Gout Patients: A Prospective Cohort Study

, 2023
Lei Pang,1– 4,* Xiaomei Xue,1– 4,* Yuwei He,1– 4 Can Wang,1– 4 Lin Han,1– 4 Maichao Li,1– 4 Han Qi,1– 4 Changgui Li,1– 4 Jie Lu1– 4 1Shandong Provincial Clinical Research Center for Immune Diseases and Gout, the Affiliated Hospital of Qingdao ...
He Y, Li C, Han L, Wang C, Qi H, Lu J, Pang L, Xue X, Li M   +8 more
core  

A Possible Exquisite Crosstalk of Urate Transporter 1 With Other Urate Transporters for Chronic Kidney Disease and Cardiovascular Disease Induced by Dotinurad. [PDF]

Cardiol Res, 2023
Yanai H, Adachi H, Hakoshima M, Katsuyama H.   +3 more
europepmc   +1 more source

Mechanisms and regulation of urate secretion in the avian renal proximal tubule

, 2011
Urate is the end product of purine metabolism in humans and birds, as well as the product of nitrogenous waste in birds. Since urate cannot be further broken down in these species, the homeostasis of plasma urate relies heavily on a balance of hepatic ...
Bataille, Amy Michele
core   +1 more source

Research progress on the regulatory mechanisms of gut and extraintestinal microbiota in gout and uric acid metabolism

Neike lilun yu shijian
Gout is an autoinflammatory metabolic disorder characterized by dysregulation of uric acid metabolism. Recent advances in metagenomics have propelled in-depth research on gout-associated microbiota, with particular attention to the gut, oral, urinary ...
Zhicheng LIU, Yinzi CHEN, Yifan YANG, Jian XU, Shuang LIU   +4 more
doaj   +1 more source